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Chrdtm1Emdr
Targeted Allele Detail
Summary
Symbol: Chrdtm1Emdr
Name: chordin; targeted mutation 1, EM De Robertis
MGI ID: MGI:2157350
Synonyms: ChdRV, Chrd-, Chrdtm1DR
Gene: Chrd  Location: Chr16:20551877-20561134 bp, + strand  Genetic Position: Chr16, 12.51 cM
Alliance: Chrdtm1Emdr page
Cleft palate and ear and cardiovascular abnormalities in Chrdtm1Emdr/Chrdtm1Emdr mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60303
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsStop codons are inserted into all three reading frames of the signal sequence followed by a frameshift and the insertion, after CR1, of IRES-lacZ and PGK-neo cassettes to further disrupt the gene. Gene transcripts were undetectable in "node stage" embryos. (J:60303, J:83662)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 55 assay results
In Structures Affected by this Mutation: 54 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrd Mutation:  31 strains or lines available
References
Original:  J:60303 Bachiller D, et al., The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature. 2000 Feb 10;403(6770):658-61
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory