Symbol
Name
ID

Smad3
SMAD family member 3
MGI:1201674

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Elevated circulating hepatic transaminase concentration	Diabetes mellitus	Atrophic scars
Disease(s) Associated with SMAD3	Elevated circulating hepatic transaminase concentration	Diabetes mellitus	Atrophic scars
Loeys-Dietz syndrome 3
pancreatic cancer

Mouse Phenotypes

abnormal vascular wound healing

decreased circulating creatinine level

increased circulating creatinine level

decreased blood urea nitrogen level

abnormal circulating interleukin-6 level

decreased circulating alkaline phosphatase level

abnormal physiological response to xenobiotic

decreased susceptibility to kidney reperfusion injury

increased susceptibility to kidney reperfusion injury

enhanced wound healing

decreased susceptibility to injury

Availability

Mouse Genotype

Smad3^tm1Cxd/Smad3^tm1Cxd

Smad3^tm1Par/Smad3^tm1Par

Smad3^tm1Sche/Smad3^tm1Sche

Smad3^em1(IMPC)H/Smad3⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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