92 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Amhr2tm3(cre)Bhr/Amhr2+ Smad3tm1Par/Smad3tm1Zuk involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	normal reproductive system phenotype	J:142827
Smad3em1(IMPC)H/Smad3+ C57BL/6NTac-Smad3em1(IMPC)H/H	decreased circulating alkaline phosphatase level	J:211773
Smad3em1(IMPC)H/Smad3em1(IMPC)H C57BL/6NTac-Smad3em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Smad3tm1Cxd/Smad3tm1Cxd B6.129S6-Smad3tm1Cxd	abnormal vascular wound healing	J:108527
	decreased renal tubule apoptosis	J:102084
	decreased susceptibility to injury	J:102084
	renal interstitial fibrosis	J:102084
	normal renal/urinary system phenotype	J:102084
	tubulointerstitial nephritis	J:102084
Smad3tm1Cxd/Smad3tm1Cxd either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)	abnormal immune system morphology	J:53510
	abnormal T cell activation	J:53510
	abnormal T cell physiology	J:53510
	abnormal thymus involution	J:53510
	colitis	J:53510
	decreased body size	J:53510
	enlarged lymph nodes	J:53510
	enlarged mesenteric lymph nodes	J:53510
	extramedullary hematopoiesis	J:53510
	impaired neutrophil chemotaxis	J:53510
	increased inflammatory response	J:53510
	increased intestinal adenocarcinoma incidence	J:53510
	increased leukocyte cell number	J:53510
	increased monocyte cell number	J:53510
	increased neutrophil cell number	J:53510
	kyphosis	J:53510
	pancreas inflammation	J:53510
	premature death	J:53510
	small intestinal inflammation	J:53510
	small spleen	J:53510
	spleen hypoplasia	J:53510
	stomach inflammation	J:53510
	thymus hypoplasia	J:53510
Smad3tm1Cxd/Smad3tm1Cxd involves: 129S6/SvEvTac	abnormal articular cartilage morphology	J:68792
	abnormal cartilage morphology	J:68792
	abnormal chondrocyte morphology	J:68792
	abnormal epiphyseal plate morphology	J:68792
	abnormal forelimb morphology	J:68792
	abnormal intestine morphology	J:75703
	abnormal joint morphology	J:68792
	abnormal keratinocyte physiology	J:59673
	abnormal kidney epithelium morphology	J:118474
	abnormal leukocyte physiology	J:59673
	abnormal locomotor behavior	J:68792
	abnormal rib morphology	J:68792
	abnormal skeleton physiology	J:68792
	abnormal synovial joint capsule morphology	J:68792
	abnormal tarsal bone morphology	J:68792
	calcified joint	J:68792
	decreased B cell apoptosis	J:140567
	decreased body size	J:75703
	decreased body weight	J:75703
	decreased bone mineral density	J:68792
	decreased primary ovarian follicle number	J:75703
	decreased secondary ovarian follicle number	J:75703
	decreased susceptibility to injury	J:118474
	decreased tertiary ovarian follicle number	J:75703
	enhanced wound healing	J:59673
	impaired ovarian folliculogenesis	J:75703
	increased primordial ovarian follicle number	J:75703
	increased width of hypertrophic chondrocyte zone	J:68792
	kyphoscoliosis	J:68792
	kyphosis	J:68792
	osteoarthritis	J:68792
	premature death	J:75703
	reduced female fertility	J:75703
Smad3tm1Cxd/Smad3tm1Cxd involves: 129S6/SvEvTac * C57BL/6	abnormal CD4-positive T cell differentiation	J:136955
	abnormal physiological response to xenobiotic	J:137529
	increased circulating creatinine level	J:137529
	increased susceptibility to kidney reperfusion injury	J:137529
	renal tubular necrosis	J:137529
Smad3tm1Par/Smad3tm1Par 129-Smad3tm1Par/J	abnormal circulating interleukin-6 level	J:175290
	abnormal cytokine secretion	J:175290
	decreased blood urea nitrogen level	J:175290
	decreased circulating creatinine level	J:175290
	decreased interleukin-6 secretion	J:175290
	decreased susceptibility to kidney reperfusion injury	J:175290
	increased inflammatory response	J:106572
	increased intestinal adenocarcinoma incidence	J:106572
Smad3tm1Par/Smad3tm1Par either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal fertility/fecundity	J:49839
	abnormal posture	J:49839
	decreased body size	J:49839
	distended abdomen	J:49839
	increased intestinal adenocarcinoma incidence	J:49839
	increased metastatic potential	J:49839
	intestinal obstruction	J:49839
	lethargy	J:49839
	premature death	J:49839
	rectal prolapse	J:49839
	ruffled hair	J:49839
Smad3tm1Sche/Smad3tm1Sche B6.129P2-Smad3tm1Sche	abnormal mesangial matrix morphology	J:145114
	abnormal physiological response to xenobiotic	J:145114
	abnormal renal glomerulus basement membrane thickness	J:145114
	decreased blood urea nitrogen level	J:145114
	decreased circulating creatinine level	J:145114
	decreased kidney weight	J:145114
	increased body weight	J:145114
Smad3tm1Xfw/Smad3tm1Xfw involves: 129/Sv * C57BL/6	abnormal B cell proliferation	J:53948
	abnormal carpal bone morphology	J:53948
	abnormal cell proliferation	J:53948
	abnormal cytokine secretion	J:53948
	abnormal rib morphology	J:53948
	abnormal sternum morphology	J:53948
	abnormal T cell proliferation	J:53948
	abnormal talus morphology	J:53948
	abnormal thoracic cage morphology	J:53948
	decreased body size	J:53948
	normal immune system phenotype	J:53948
	kyphosis	J:53948