Jag1
Gene Detail

Symbol Name ID

Jag1 jagged 1 MGI:1095416

Synonyms

ABE2, Gsfabe2, Headturner, Htu, Ozz, Serrate-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

67.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:137081456-137116644 bp, - strand From VEGA annotation of GRCm38   35189 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Jag1

Human homologs

Human Homolog		JAG1, jagged 1
NCBI Gene ID		182
neXtProt AC		NX_P78504
Human Synonyms		AGS, AHD, AWS, CD339, HJ1, JAGL1
Human Chr (Location)		20p12.1-p11.23; chr20:10618332-10654694 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human JAG1

Alleles and phenotypes

All alleles(26) : Targeted(8) Gene trapped(12) Chemically induced(6)
 

Homozygous null mutants exhibit extensive hemorrhaging and die prior to embryonic day 11.5, while heterozygotes exhibit defects of the eye. Heterozygotes for missense mutations have inner ear abnormalities. Other mutant mice display abnormal head movements.

 
Human Diseases Modeled Using Mouse Jag1 (2)    Alleles Annotated to Human Diseases(4)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	aorta morphogenesis, auditory receptor cell differentiation, ...
Component	apical part of cell, integral to membrane, ...
Function	calcium ion binding, Notch binding, ...

External Resources: FuncBase

Expression

Literature Summary: (225 records)
Data Summary: Results (586)    Tissues (320)    Images (149)
Theiler Stages: 1, 2, 3, 4, 5, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	15
RNA in situ	502
Northern blot	11
RT-PCR	58

cDNA source data(51)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(75) Genomic(1) cDNA(57) Primer pair(8) Other(9)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015560 (Evidence)
Ensembl Gene Model	ENSMUSG00000027276 (Evidence)
Entrez Gene	16449 (Evidence)
UniGene	22398
DFCI	TC1578527
DoTS	DT.527087, DT.529573
NIA Mouse Gene Index	U023414
Consensus CDS Project	CCDS16797.1
International Mouse Knockout Project Status	Jag1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015560	VEGA Gene Model | MGI Sequence Detail	35189	C57BL/6J
transcript	OTTMUST00000036966	VEGA | MGI Sequence Detail	5612	Not Applicable
polypeptide	OTTMUSP00000016586	VEGA | MGI Sequence Detail	1218	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(195 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001774	Delta/Serrate/lag-2 (DSL) protein
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR026219	Jagged/Serrate protein
InterPro	IPR011651	Notch ligand, N-terminal
InterPro	IPR001007	von Willebrand factor, type C
Protein Ontology	PR:000001921	protein jagged-1

References

(Earliest) J:113824 Zimrin AB, et al., An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro. J Biol Chem. 1996 Dec 20;271(51):32499-502
(Latest) J:195070 Luxan G, et al., Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med. 2013 Feb;19(2):193-201
All references(306)

Other accession IDs

MGI:1891333, MGI:2664252, MGI:3530800