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Ifng Gene Detail
Summary
  • Symbol
    Ifng
  • Name
    interferon gamma
  • Synonyms
    Ifg, IFN-gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:107656
    NCBI Gene: 15978
  • Gene Overview
    MyGene.info: IFNG
Location & Maps
more
  • Sequence Map
    Chr10:118441047-118445892 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4846 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.75 cM
  • Mapping Data
    48 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    IFNG, interferon gamma
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IFNG, interferon gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IFG, IFI
  • Links
    NCBI Gene ID: 3458
    neXtProt AC: NX_P01579

  • Chr Location
    12q14; chr12:68154770-68159741 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Ifng mouse models; 5 with human IFNG associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 2 models
Malaria, Susceptibility to   OMIM: 611162 View 1 model
Medulloblastoma; MDB   OMIM: 155255 View 2 models
       Aplastic Anemia   OMIM: 609135
Hepatitis C Virus, Susceptibility to   OMIM: 609532
Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
Mycobacterium Tuberculosis, Susceptibility to   OMIM: 607948
Tuberous Sclerosis 2; TSC2   OMIM: 613254
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    138 phenotypes from 7 alleles in 24 genetic backgrounds
    92 phenotypes from multigenic genotypes
    1026 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Targeted
    10
  • Transgenic
    3
  • Genomic Mutations
    1 involving Ifng
  • Incidental Mutations
Mutants show immune system abnormalities including decreased inflammatory response in one line, and uncontrolled splenocyte proliferation and susceptibility to intracellular pathogens in another.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15978 NCBI Gene Model | MGI Sequence Detail 4846 C57BL/6J ±  kb
transcript NM_008337 RefSeq | MGI Sequence Detail 1210 C57BL/6  
polypeptide P01580 UniProt | EBI | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    30 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 21
    cDNA 15
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11214, MGD-MRK-36231
References
more
  • Summaries
    All 1517
    Developmental Gene Expression 18
    Diseases 4
    Gene Ontology 52
    Phenotypes 1026
  • Earliest
    J:19935 Gray PW, et al., Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci U S A. 1983 Oct;80(19):5842-6
  • Latest
    J:229679 Siemsen DW, et al., Vascular Dysfunction in Pneumocystis-Associated Pulmonary Hypertension Is Related to Endothelin Response and Adrenomedullin Concentration. Am J Pathol. 2016 Feb;186(2):259-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory