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Phenotype Images associated with this Transgene
Nomenclature
Symbol: Tg(Nes-cre)1Kln
Name: transgene insertion 1, Rudiger Klein
MGI ID: MGI:2176173
Synonyms: n-Cre+, Nes11Cre, NesCre, nestin-Cre, nestin/Cre, Nestin:Cre, Tg(Nes-cre)
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Small size of Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Nes-cre)1Kln/0 mice at P10Vps18tm1.1Wtao/Vps18tm1.1Wtao
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL
Smaller cerebrums and cerebellums in Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Nes-cre)1Kln/0 miceVps18tm1.1Wtao/Vps18tm1.1Wtao
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL
Neurodegeneration in Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Nes-cre)1Kln/0 and Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Pcp2-cre)2Mpin/0 brainsVps18tm1.1Wtao/Vps18tm1.1Wtao
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL
Vps18tm1.1Wtao/Vps18tm1.1Wtao
Tg(Pcp2-cre)2Mpin/0
B.129-Vps18tm1.1Wtao Tg(Pcp2-cre)2Mpin
Accumulation of autophagosomes, late endosomes and amorphous densely stained vesicles in Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Nes-cre)1Kln/0 brainsVps18tm1.1Wtao/Vps18tm1.1Wtao
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL
Ndfip1tm1Sest/Ndfip1tm1Sest Tg(Nes-cre)1Kln/0 mice show increased infract size after hypoxia-ischemiaNdfip1tm1Sest/Ndfip1tm1Sest
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Ndfip1tm1Sest/Ndfip1tm1Sest Tg(Nes-cre)1Kln/0 mice show increased neuron death after hypoxia-ischemiaNdfip1tm1Sest/Ndfip1tm1Sest
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Cerebellar ataxia in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Cerebellar development abnormalities in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Increased apoptotic cell death in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 cerebellaSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Impaired cerebellar granule cell maturation and migration in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Purkinje cell defects in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Reduced synaptic density in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 miceSmad2tm1.1Nomu/Smad2tm1.1Nomu
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Decreased body size and reduced dopaminergic neurons in Atmintm1Axbe/Atmintm1Axbe Tg(Nes-cre)1Kln/0 miceAtmintm1Axbe/Atmintm1Axbe
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Increased neurodegeneration in Atmintm1Axbe/Atmintm1Axbe Tg(Nes-cre)1Kln/0 brainsAtmintm1Axbe/Atmintm1Axbe
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Neurodegenerative changes in the midbrain of Atmintm1Axbe/Atmintm1Axbe Tg(Nes-cre)1Kln/0 miceAtmintm1Axbe/Atmintm1Axbe
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Growth retardation, ataxia, small brain size, and reduced olfactory bulb size in Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 miceTg(Nes-cre)1Kln/0
Triotm1Mzhu/Triotm1Mzhu
involves: 129S6/SvEvTac * C57BL/6 * SJL
Developmental defects of the Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 cerebellumTg(Nes-cre)1Kln/0
Triotm1Mzhu/Triotm1Mzhu
involves: 129S6/SvEvTac * C57BL/6 * SJL
Defective migration of granule cells in Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 cerebellaTg(Nes-cre)1Kln/0
Triotm1Mzhu/Triotm1Mzhu
involves: 129S6/SvEvTac * C57BL/6 * SJL
Disrupted formation of parallel fibers in Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 miceTg(Nes-cre)1Kln/0
Triotm1Mzhu/Triotm1Mzhu
involves: 129S6/SvEvTac * C57BL/6 * SJL
Impaired formation of neurites in Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 microexplant culturesTg(Nes-cre)1Kln/0
Triotm1Mzhu/Triotm1Mzhu
involves: 129S6/SvEvTac * C57BL/6 * SJL
Gbatm1Karl/Gbatm1Karl Tg(Nes-cre)1Kln/? mice exhibit a more profound activation and proliferation of microglial cells than Gbatm2Karl/Gbatm2Karl Tg(KRT14-cre)8Brn/? miceGbatm2Karl/Gbatm2Karl
Tg(KRT14-cre)8Brn/?
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Gbatm1Karl/Gbatm1Karl
Tg(Nes-cre)1Kln/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Neural-specific STAT3 deletion results in severe obesity in Stat3tm1Flv/Stat3tm1Flv Tg(Nes-cre)1Kln/0 mice similar to that seen in Leprdb/Leprdb miceLeprdb/Leprdbinvolves: C57BLKS/J
Stat3tm1Flv/Stat3tm1Flv
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Hyperphagia and fatty livers in Stat3tm1Flv/Stat3tm1Flv Tg(Nes-cre)1Kln/0 miceStat3tm1Flv/Stat3tm1Flv
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Stat3tm1Flv/Stat3tm1Flv Tg(Nes-cre)1Kln/0 mice are infertile, hypogonadal and shortStat3tm1Flv/Stat3tm1Flv
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL
Adipose tissue is altered in Stat3tm1Flv/Stat3tm1Flv Tg(Nes-cre)1Kln/0 miceStat3tm1Flv/Stat3tm1Flv
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory