Pkd1tm3.1Bol
Targeted Allele Detail
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Symbol: |
Pkd1tm3.1Bol |
Name: |
polycystin 1, transient receptor potential channel interacting; targeted mutation 3.1, Alessandra Boletta |
MGI ID: |
MGI:4366014 |
Synonyms: |
Pkd1Myc |
Gene: |
Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
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Alliance: |
Pkd1tm3.1Bol page
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Hydrocephalus in Pkd1tm2.2Bol/Pkd1tm3.1Bol Tg(Nes-cre)1Kln/0 mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:153606
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Parent Cell Line: |
TBV2 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 45 and a myc tag, a loxP site, an HA tag, and an frt flanked neo cassette were inserted downstream of exon 46. Germ line, flp mediated recombination removed the neo cassette leaving exons 45 and 46 floxed.
(J:153606)
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Generation of the Pkd1tm3.1Bol and Pkd1tm3.2Bol alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pkd1 Mutation: |
153 strains or lines available
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Original: |
J:153606 Wodarczyk C, et al., A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One. 2009;4(9):e7137 |
All: |
2 reference(s) |
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