Triotm1Mzhu
Targeted Allele Detail
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Symbol: |
Triotm1Mzhu |
Name: |
triple functional domain (PTPRF interacting); targeted mutation 1, Min-Sheng Zhu |
MGI ID: |
MGI:4839231 |
Synonyms: |
Trioflox |
Gene: |
Trio Location: Chr15:27730737-28025934 bp, - strand Genetic Position: Chr15, 10.4 cM
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Alliance: |
Triotm1Mzhu page
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Growth retardation, ataxia, small brain size, and reduced olfactory bulb size in Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 mice
Show the 6 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:165902
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Parent Cell Line: |
W4 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 22 and an additional loxP site was inserted downstream of exon 26.
(J:165902)
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Generation of the Triotm1Mzhu allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trio Mutation: |
132 strains or lines available
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Original: |
J:165902 Peng YJ, et al., Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum. J Biol Chem. 2010 Aug 6;285(32):24834-44 |
All: |
8 reference(s) |
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