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| Caption | B, 90% of Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 mutant mice (TrioNKO) died within 24 hours after birth without sucking milk (arrowhead, control stomach filled with milk). Few mutants could survive for 3 weeks with severe ataxia, retarded growth, and smaller brain size. Asterisks indicate the knock-out mice. C and D, Nissl-stained sagittal sections show a reduced size of the mutant olfactory bulb and an enlarged rostral migratory stream (RMS, arrowheads) at P0.5. E and F, hematoxylin and eosin-stained coronal sections of the olfactory bulbs of P21 mice. The mitral cell layer (MCL) is clearly visible in the control mice (arrowheads) but cannot be distinguished from the internal granule cell layer in the mutant mice. G and H, lamination defects of the hippocampus in Trio mutant mice. At P21, granule cells of dentate gyrus (DG) are tightly arranged in the control mice, but not in the mutant (arrowheads). | ||||||
| Copyright | This image is from Peng YJ, J Biol Chem 2010 Aug 6;285(32):24834-44 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165902 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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