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Trio Gene Detail
Summary
  • Symbol
    Trio
  • Name
    triple functional domain (PTPRF interacting)
  • Synonyms
    6720464I07Rik, Solo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927230
    NCBI Gene: 223435
  • Alliance
    genome feature page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:27730737-28025934 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 10.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9079 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927230
 protein coding gene Chr15:27730735-28025954 (-)
129S1/SvImJ ENSMUSG00200026597
 protein coding gene Chr15:24745057-24839694 (-)
129S1/SvImJ ENSMUSGG00200054388
 protein coding gene Chr15:24900364-24916816 (-)
A/J ENSMUSGG00195055289
 protein coding gene Chr15:24853532-24869986 (-)
A/J ENSMUSG00195013516
 protein coding gene Chr15:24697586-24792433 (-)
AKR/J ENSMUSGG00220054536
 protein coding gene Chr15:24716981-24733433 (-)
AKR/J ENSMUSG00220024209
 protein coding gene Chr15:24561045-24655884 (-)
BALB/cJ ENSMUSGG00180055416
 protein coding gene Chr15:24796862-24813316 (-)
BALB/cJ ENSMUSG00180005345
 protein coding gene Chr15:24640899-24735758 (-)
C3H/HeJ ENSMUSGG00175054763
 protein coding gene Chr15:24952609-24969061 (-)
C3H/HeJ ENSMUSG00175004647
 protein coding gene Chr15:24796662-24891504 (-)
C57BL/6NJ ENSMUSGG00215055550
 protein coding gene Chr15:24852948-24869403 (-)
C57BL/6NJ ENSMUSG00215004801
 protein coding gene Chr15:24696996-24791845 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019704
 protein coding gene Chr15:23126757-23413354 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054824
 protein coding gene Chr15:24899330-24915784 (-)
CBA/J ENSMUSG00210024007
 protein coding gene Chr15:24743397-24838228 (-)
DBA/2J ENSMUSG00185022693
 protein coding gene Chr15:24735989-24830836 (-)
DBA/2J ENSMUSGG00185057761
 protein coding gene Chr15:24891937-24908389 (-)
FVB/NJ ENSMUSG00205012204
 protein coding gene Chr15:24679790-24774635 (-)
FVB/NJ ENSMUSGG00205054431
 protein coding gene Chr15:24835736-24852188 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055688
 protein coding gene Chr15:28369876-28386328 (-)
LP/J ENSMUSG00230014522
 protein coding gene Chr15:28214566-28309204 (-)
NOD/ShiLtJ ENSMUSG00190012133
 protein coding gene Chr15:24719758-24814599 (-)
NOD/ShiLtJ ENSMUSGG00190054860
 protein coding gene Chr15:24875695-24892147 (-)
NZO/HlLtJ ENSMUSG00225031755
 protein coding gene Chr15:28456825-28551666 (-)
NZO/HlLtJ ENSMUSGG00225055547
 protein coding gene Chr15:28612768-28629220 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010023033
 protein coding gene Chr15:25333340-25627599 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TRIO, trio Rho guanine nucleotide exchange factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIO, trio Rho guanine nucleotide exchange factor
  • Synonyms
    ARHGEF23, MEBAS, MRD44, MRD63, tgat
  • Links
    NCBI Gene ID: 7204
    UniProt: O75962

  • Chr Location
    5p15.2; chr5:14143342-14532128 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TRIO associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 4 genetic backgrounds
    6 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die during late embryonic development or shortly after birth. They exhibit abnormal skeletal myogenesis and display aberrant organization within the hippocampus and olfactory bulb.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    62
  • cDNA Data
    14
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022263 Ensembl Gene Model | MGI Sequence Detail 295198 C57BL/6J ±  kb
    transcript ENSMUST00000090247 Ensembl | MGI Sequence Detail 11495 Not Applicable  
    polypeptide ENSMUSP00000087714 Ensembl | MGI Sequence Detail 3103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 15
      Primer pair 4
      Other 3
      Antibodies 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1924980, MGI:2145897
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 34
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387264 Ishchenko Y, et al., Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice. Elife. 2025 Jun 9;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory