Phenotype Image Detail

Image

Caption

Seminal vesicles (A) as well as testes (B) as smaller in Stat3^tm1Flv/Stat3^tm1Flv Tg(Nes-cre)1Kln/0 (KO) males. C: Uterine horns of female mutant mice are markedly decreased in size as well. D and E: Immunocytochemistry of the lateral arcuate nucleus in wild type (WT) and mutant with anit-beta-endorphin for POMC neurons diaminobenzidine (brown) and anti-NYP nickel diaminobenzidine (dark) (magnification, x40). POMC staining (*) was not seen in mutant mice. F and G: Mutant mice showed overexpression of AgRP in the medial arcuate nucleus. Wild type and mutant medial arcuate nuclei were stained by using anti-AgRP (Calbiochem) at 1:5,000. H: An x-ray image of wild type and mutant mice showing decreased linear size and increased body mass. I: Snout-anus measurements.

Copyright

This image is from Gao Q, Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4661-6. Copyright 2004 National Academy of Sciences, U.S.A. J:89242

Associated Alleles

Symbol	Name
Stat3^tm1Flv	signal transducer and activator of transcription 3; targeted mutation 1, Richard A Flavell
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Stat3^tm1Flv/Stat3^tm1Flv Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL