Gba^tm1Karl
Targeted Allele Detail

Summary

• Symbol: Gba^tm1Karl
• Name: glucosidase, beta, acid; targeted mutation 1, Stefan Karlsson
• MGI ID: MGI:3687965
• Synonyms: GC^flox
• Gene: Gba Location: Chr3:89110223-89116180 bp, + strand Genetic Position: Chr3, 39.01 cM
• Alliance: Gba^tm1Karl page

Gba^tm1Karl/Gba^tm1Karl Tg(Nes-cre)1Kln/? mice exhibit a more profound activation and proliferation of microglial cells than Gba^tm2Karl/Gba^tm2Karl Tg(KRT14-cre)8Brn/? mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113751
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 9-11 were flanked with loxP sites. (J:113751)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gba Mutation: 34 strains or lines available

References

• Original: J:113751 Enquist IB, et al., Effective cell and gene therapy in a murine model of Gaucher disease. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13819-24
• All: 19 reference(s)