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All mouse models of organ system benign neoplasm with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | arteriovenous malformations of the brain | \Engtm2.1Hma/\Engtm2.1Hma | involves: 129P2/OlaHsd | J:196810 | View | |||
| arteriovenous malformations of the brain |
\Krastm4Tyj/\Kras+ \Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129S4/SvJae * FVB | J:312482 | View | ||||
| arteriovenous malformations of the brain |
\Krastm4Tyj/\Kras+ \Tg(Slco1c1-icre/ERT2)1Mash/0 |
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB | J:312482 | View | ||||
| infantile myofibromatosis | \Pdgfrbb2b2903Clo/\Pdgfrbb2b2903Clo | C57BL/6J-Pdgfrbb2b2903Clo | J:175213 | View | ||||
| pheochromocytoma | \Rettm2.1Cos/\Rettm2.1Cos | involves: 129S1/Sv * C57BL/6J * FVB/N | J:60659 | View | ||||
| von Hippel-Lindau disease |
\Hif1atm3Rsjo/\Hif1atm3Rsjo \Hprt1tm1(Pck1-cre)Vhh/Y \Vhltm1Jae/\Vhltm1Jae |
involves: 129 * BALB/c * C57BL/6 | J:97652, J:106705 | View | ||||
| von Hippel-Lindau disease |
\Hif1atm3Rsjo/\Hif1atm3Rsjo \Vhltm1Jae/\Vhltm1Jae \Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+ |
involves: 129 * BALB/c * C57BL/6 * DBA | J:97652 | View | ||||
| von Hippel-Lindau disease |
\Hprt1tm1(Pck1-cre)Vhh/Y \Vhltm1Jae/\Vhltm1Jae |
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 | J:97652, J:106705 | View | ||||
| von Hippel-Lindau disease |
\Ptentm1Hwu/\Ptentm1Hwu \Vhltm1Jae/\Vhltm1Jae \Tg(Cdh16-cre)91Igr/0 |
involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR | J:137073 | View | ||||
| von Hippel-Lindau disease |
\Ptentm1Hwu/\Ptentm1Hwu \Vhltm1Jae/\Vhltm1Jae \Tg(Cdh16-cre)91Igr/0 |
involves: 129S4/SvJae * ICR | J:137442 | View | ||||
| von Hippel-Lindau disease | \Vhltm1.1Jae/\Vhl+ | involves: 129S4/SvJae * BALB/c | J:67505 | View | ||||
| von Hippel-Lindau disease | \Vhltm1.1Lss/\Vhl+ | involves: A/J | J:85513 | View | ||||
| von Hippel-Lindau disease | \Vhltm1.1Lss/\Vhl+ | involves: BALB/c | J:85513 | View | ||||
| von Hippel-Lindau disease | \Vhltm1.1Wkr/\Vhl+ | involves: 129S4/SvJae * C57BL/6 | J:157369 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Jae/\Vhltm1Jae \Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+ |
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA | J:67505, J:97652 | View | ||||
| von Hippel-Lindau disease | \Vhltm1Lss/\Vhltm1.1Lss | involves: 129X1/SvJ * C57BL/6 | J:85513 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Lss/\Vhltm1.1Lss \Tg(ACTB-cre)1Tes/0 |
involves: 129X1/SvJ * C3H * C57BL/6 | J:85513 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Lss/\Vhltm1Lss \Tg(Gcg-cre)1Slib/0 |
either: (involves: 129X1/SvJ * A/J) or (involves: 129X1/SvJ * C57BL/6) | J:148174 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Lss/\Vhltm1Lss \Tg(Ins2-cre)25Mgn/0 |
either: (involves: 129X1/SvJ * C57BL/6 * DBA) or (involves: 129X1/SvJ * A/J * C57BL/6 * DBA) | J:148174 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Lss/\Vhltm1Lss \Tg(Pdx1-cre)89.1Dam/0 |
involves: 129X1/SvJ * C57BL/6 * CBA | J:148174 | View | ||||
| von Hippel-Lindau disease | \Vhltm1Wml/\Vhltm1Wml | involves: 129S4/SvJae * C57BL/6 | J:42846, J:88492 | View | ||||
| | arteriovenous malformations of the brain | \Acvrl1tm2.1Spo/\Acvrl1tm2.1Spo | involves: 129 | J:196810 | View | |||
| arteriovenous malformations of the brain |
\Tg(Tek-tTA)1Rwng/0 \Tg(tetO-Notch4*)1Rwng/0 |
involves: FVB/N | J:139943 | View | ||||
| dermoid cyst of ovary |
\Foxo3mommeR1/\Foxo3mommeR1 \Tg(HBA1-GFP)1Ew/\Tg(HBA1-GFP)1Ew |
FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew | J:170710 | View | ||||
| epidermal appendage tumor | \Tg(Tff3-Tmem207)1Tamo/0 | C57BL/6-Tg(Tff3-Tmem207)1Tamo | J:217436 | View | ||||
| growth hormone secreting pituitary adenoma | \Men1tm1Zqw/\Men1+ | involves: 129/Sv * 129P2/OlaHsd | J:85302 | View | ||||
| hepatocellular adenoma |
\Ptpn11tm1Gsf/\Ptpn11tm1Gsf \Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA | J:172422 | View | ||||
| prolactinoma | \Men1tm1Zqw/\Men1+ | involves: 129/Sv * 129P2/OlaHsd | J:85302 | View | ||||
| uterine fibroid |
\Tsc2tm1.1Mjg/\Tsc2tm1.1Mjg \Pgrtm2(cre)Lyd/\Pgr+ |
involves: 129S1/Sv * 129X1/SvJ | J:221228 | View | ||||
| | pheochromocytoma |
\Ptentm1Mro/\Ptentm1Mro \Sdhbtm1.1Ics/\Sdhb+ \Tg(KLK3-cre)D4Trp/0 |
involves: 129S2/SvPas * FVB | J:236514 | View | |||
| Transgenes and Other Mutations | ACTH-secreting pituitary adenoma | \Tg(PyLT)1Vb/0 | Not Specified | J:55528 | View | |||
| choroid plexus papilloma |
\Smarcb1tm1Sho/\Smarcb1+ \Tg(LPV-TAg121)2Tvd/0 |
involves: 129S6/SvEvTac * C57BL/6J * DBA/2J | J:120820 | View | ||||
| choroid plexus papilloma | \Tg(LPV-TAg121)2Tvd/0 | involves: 129S6/SvEvTac * C57BL/6J * DBA/2J | J:120820 | View | ||||
| dermoid cyst of ovary | \Tg(Amh-SMAD2*)#Jebu/0 | FVB/N-Tg(Amh-SMAD2*)#Jebu | J:200783 | View | ||||
| insulinoma | \Tg(RIP1-Tag)2Dh/0 | involves: C57BL/6J * DBA/2J | J:205389 | View | ||||
| lung benign neoplasm |
\Tg(Scgb1a1-rtTA)1Jaw/0 \Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0 |
involves: FVB/N | J:102839 | View | ||||
| lung benign neoplasm |
\Tg(SFTPC-rtTA)5Jaw/0 \Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0 |
involves: FVB/N | J:102839 | View | ||||
| prolactinoma | \Tg(Prl-EGFR)#Sme/0 | Not Specified | J:219654 | View | ||||
| von Hippel-Lindau disease | \Tg(Ggt1-Hif1a*)43Log/0 | involves: C57BL/6 | J:177381 | View | ||||
| Additional Complex Models | pancreatic mucinous cystadenoma |
\Apctm2Rak/\Apc+ \Trp53tm1Brn/\Trp53tm1Brn \Tg(Pdx1-cre)6Tuv/0 |
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL | J:234310 | View | |||
| seborrheic keratosis |
\Psen1tm1Bdes/\Psen1+ \Psen2tm1Bdes/\Psen2tm1Bdes |
involves: 129P2/OlaHsd | J:91235 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | paraganglioma |
\Sdhctm1c(EUCOMM)Wtsi/\Sdhctm1c(EUCOMM)Wtsi \Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn/\Gt(ROSA)26Sor+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N | J:284745 | View | |||
| paraganglioma | \Sdhdtm1Jlob/\Sdhd+ | involves: 129X1/SvJ | J:95252 | View | ||||
| paraganglioma | \Sdhdtm1Jlob/\Sdhdtm1Jlob | involves: 129X1/SvJ | J:95252 | View | ||||
| paraganglioma | \Sdhdtm1Jpb/\Sdhd+ | either: 129P2/OlaHsd-Sdhdtm1Jpb or (involves: 129P2/OlaHsd * C57BL/6J) | J:155380 | View | ||||
| pheochromocytoma | \Rettm1Cos/\Rettm2.1Cos | involves: 129S/SvEv * 129S1/Sv * C57BL/6J * FVB/N * MF1 | J:60659 | View | ||||