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Targeted Allele Detail
Symbol: Men1tm1Zqw
Name: multiple endocrine neoplasia 1; targeted mutation 1, Zhao-Qi Wang
MGI ID: MGI:2664869
Synonyms: Men1T
Gene: Men1  Location: Chr19:6385009-6390921 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Alliance: Men1tm1Zqw page
Germline Transmission:  Earliest citation of germline transmission: J:83882
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA cassette expressing the neomycin resistance gene and the thymidine kinase gene flanked by loxP sites was inserted into intron 2. An additional loxP site was placed in intron 3. Homologous recombination was confirmed by Southern blots. The insertion of a neoTK cassette into intron 2 of the Men1 locus (the T allele) disrupted the Men1 expression at RNA and protein levels, as shown by RT-PCR and Western blot, respectively. (J:83882)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 15 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Men1tm1Zqw
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:  40 strains or lines available
Original:  J:83882 Bertolino P, et al., Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech Dev. 2003 May;120(5):549-60
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.24
The Jackson Laboratory