Phenotypes Associated with This Genotype

Genotype
MGI:5696742

• Allelic Composition: Tg(Prl-EGFR)#Sme/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prolactinoma incidence ( J:219654 )

♀ • 5 of 20 females develop pituitary tumors at 13-15 months of age; tumors are prolactinomas

homeostasis/metabolism

increased circulating prolactin level ( J:219654 )

♀ • circulating prolactin levels are increased 3.8-fold

♀ • treatment with lapatinib for 3 weeks attenuates circulating prolactin levels

endocrine/exocrine glands

increased prolactinoma incidence ( J:219654 )

♀ • 5 of 20 females develop pituitary tumors at 13-15 months of age; tumors are prolactinomas

nervous system

increased prolactinoma incidence ( J:219654 )

♀ • 5 of 20 females develop pituitary tumors at 13-15 months of age; tumors are prolactinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prolactinoma		DOID:5394		J:219654