Phenotypes Associated with This Genotype

Genotype
MGI:4949205

• Allelic Composition: Foxo3^mommeR1/Foxo3^mommeR1; Tg(HBA1-GFP)1Ew/Tg(HBA1-GFP)1Ew
• Genetic Background: FVB/NJ-Foxo3^mommeR1 Tg(HBA1-Gfp)1Ew

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal oocyte morphology ( J:170710 )

♀ • at P3 some primordial follicles show an increase in the size of primary oocytes

abnormal polar body morphology ( J:170710 )

♀ • oocytes are less likely to have a polar body on ovulation

reproductive system

abnormal polar body morphology ( J:170710 )

♀ • oocytes are less likely to have a polar body on ovulation

absent corpus luteum ( J:170710 )

♀ • at 18 weeks of age

increased corpora lutea number ( J:170710 )

♀ • at P30 compared to heterozygous controls

abnormal ovarian follicle morphology ( J:170710 )

♀ • in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30

abnormal ovarian follicle number ( J:170710 )

♀ • increase in the number of follicles at P30

decreased primary ovarian follicle number ( J:170710 )

♀ • marked decrease in the number of primary follicles at P60

increased secondary ovarian follicle number ( J:170710 )

♀ • increase in the number of secondary follicles at P30

absent ovarian follicles ( J:170710 )

♀ • at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles

abnormal primordial ovarian follicle morphology ( J:170710 )

♀ • at P3 some primordial follicles show an increase in the size of primary oocytes

♀ • at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells

decreased primordial ovarian follicle number ( J:170710 )

♀ • marked decrease in the number of primordial follicles at P60

♀ • at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles

enlarged ovary ( J:170710 )

♀ • at P30 compared to heterozygous controls

♀ • at 1 year of age occasional females have grossly enlarged ovaries

increased ovarian teratoma incidence ( J:170710 )

♀ • found in grossly enlarged ovaries at 1 year of age

♀ • Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background

abnormal ovary physiology ( J:170710 )

♀ • apparent asynchronous development of the oocyte and follicle

early reproductive senescence ( J:170710 )

• females lose fertility by about 8 weeks of age

• however, males display normal fertility

abnormal oogenesis ( J:170710 )

♀ • apparent asynchronous development of the oocyte and follicle

abnormal oocyte morphology ( J:170710 )

♀ • at P3 some primordial follicles show an increase in the size of primary oocytes

abnormal superovulation ( J:170710 )

♀ • oocytes from superovulated females are less likely to have a polar body on the day of ovulation

♀ • increased proportion of superovulated oocytes that are arrested at metaphase of meiosis I

♀ • oocytes cultured overnight are more likely to fragment than those from superovulated heterozygous females

neoplasm

increased ovarian teratoma incidence ( J:170710 )

♀ • found in grossly enlarged ovaries at 1 year of age

♀ • Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background

growth/size/body

enlarged ovary ( J:170710 )

♀ • at P30 compared to heterozygous controls

♀ • at 1 year of age occasional females have grossly enlarged ovaries

mortality/aging

early reproductive senescence ( J:170710 )

• females lose fertility by about 8 weeks of age

• however, males display normal fertility

endocrine/exocrine glands

absent corpus luteum ( J:170710 )

♀ • at 18 weeks of age

increased corpora lutea number ( J:170710 )

♀ • at P30 compared to heterozygous controls

abnormal ovarian follicle morphology ( J:170710 )

♀ • in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30

abnormal ovarian follicle number ( J:170710 )

♀ • increase in the number of follicles at P30

decreased primary ovarian follicle number ( J:170710 )

♀ • marked decrease in the number of primary follicles at P60

increased secondary ovarian follicle number ( J:170710 )

♀ • increase in the number of secondary follicles at P30

absent ovarian follicles ( J:170710 )

♀ • at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles

abnormal primordial ovarian follicle morphology ( J:170710 )

♀ • at P3 some primordial follicles show an increase in the size of primary oocytes

♀ • at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells

decreased primordial ovarian follicle number ( J:170710 )

♀ • marked decrease in the number of primordial follicles at P60

♀ • at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles

enlarged ovary ( J:170710 )

♀ • at P30 compared to heterozygous controls

♀ • at 1 year of age occasional females have grossly enlarged ovaries

increased ovarian teratoma incidence ( J:170710 )

♀ • found in grossly enlarged ovaries at 1 year of age

♀ • Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background

abnormal ovary physiology ( J:170710 )

♀ • apparent asynchronous development of the oocyte and follicle

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dermoid cyst of ovary		DOID:5117	OMIM:166950	J:170710