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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Itgax-cre)1-1Reiz
transgene insertion 1-1, Boris Reizis
MGI:3763248
Summary 28 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Myd88tm1Defr/Myd88tm1Defr
Tg(Itgax-cre)1-1Reiz/0
B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz MGI:3809643
cn2
Rptortm1Ahir/Rptortm1Ahir
Tg(Itgax-cre)1-1Reiz/0
B6.Cg-Rptortm1Ahir Tg(Itgax-cre)1-1Reiz MGI:5441610
cn3
Pld4tm1.1Nemz/Pld4tm1.1Nemz
Tg(Itgax-cre)1-1Reiz/0
involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:6452099
cn4
Il15ratm1Ama/Il15ratm2.1Ama
Lyz2tm1(cre)Ifo/0
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA MGI:4417844
cn5
Myd88tm1Defr/Myd88tm1Defr
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:5547520
cn6
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3763283
cn7
Syktm1.2Tara/Syktm1.2Tara
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5314240
cn8
Lyntm1.1Calo/Lyntm1.1Calo
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5545813
cn9
Lyntm1.1Calo/Lyntm1.1Calo
Myd88tm1Defr/Myd88tm1Defr
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5545814
cn10
Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5563543
cn11
Cx3cr1tm3(DTR)Litt/Cx3cr1tm3(DTR)Litt
Tg(Itgax-cre)1-1Reiz/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5570963
cn12
Braftm1Mmcm/Braftm1Mmcm
Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:6192275
cn13
Il6tm1Kopf/Il6+
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA MGI:5515639
cn14
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Itgax-cre)1-1Reiz/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5545809
cn15
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5515634
cn16
Rab32tm1c(KOMP)Wtsi/Rab32tm1c(KOMP)Wtsi
Tg(Itgax-cre)1-1Reiz/0
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * CBA MGI:6393530
cn17
Zranb1tm1c(EUCOMM)Hmgu/Zranb1tm1c(EUCOMM)Hmgu
Tg(Itgax-cre)1-1Reiz/0
involves: 129S4/SvJaeSor * C57BL/6N * CBA MGI:5897848
cn18
Il15ratm1Ama/Il15ratm2.1Ama
Tg(Itgax-cre)1-1Reiz/0
involves: 129X1/SvJ * C57BL/6J * CBA MGI:4417842
cn19
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce/Gt(ROSA)26Sor+
Tg(Itgax-cre)1-1Reiz/0
involves: C3H * C57BL/6 * C57BL/6J MGI:6196862
cn20
Cxcr5tm1.1Namt/Cxcr5tm1.1Namt
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * C57BL/6J * CBA MGI:5903128
cn21
Pycardtm1Ayaz/Pycardtm1Ayaz
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * C57BL/6J * CBA MGI:5467386
cn22
Cxcr5tm1.1Namt/Cxcr5tm1.1Namt
Tg(Itgax-cre)1-1Reiz/0
Tg(Prnp)a20Cwe/0
involves: C57BL/6 * C57BL/6J * CBA MGI:5903129
cn23
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * C57BL/6J * CBA MGI:5547518
cn24
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Itgax-cre)1-1Reiz/?
involves: C57BL/6 * C57BL/6N * CBA MGI:5696542
cn25
Ddx41tm1.1Arte/Ddx41tm1.1Arte
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * C57BL/6N * CBA MGI:6401463
cn26
Sec22btm1c(EUCOMM)Wtsi/Sec22btm1c(EUCOMM)Wtsi
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * C57BL/6N * CBA * SJL MGI:6156916
cn27
Id2tm2.1Gtbz/Id2tm2.1Gtbz
Tg(Itgax-cre)1-1Reiz/0
involves: C57BL/6 * CBA MGI:5486200
cn28
Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tg(Itgax-cre)1-1Reiz/0
Tyrc-2J/Tyrc-2J
involves: C57BL/6 * CBA MGI:5007897


Genotype
MGI:3809643
cn1
Allelic
Composition
Myd88tm1Defr/Myd88tm1Defr
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Defr mutation (3 available); any Myd88 mutation (43 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice
• maturation markers on DCs such as I-Ab, CD80, and CD86 have several fold lower expression than in controls
• less Th1 T cells develop when nave antigen-specific T cells are transferred into these mice with cognate antigen and a TLR9 agonist
• antigen specific IgG1 levels are lower by almost an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist
• antigen specific IgG2b levels are lower by an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist
• antigen specific IgG2c levels are lower by several orders of magnitude than controls after immunization with OVA-peptide and TLR9 agonist
• NK cells in vivo make much several fold less IFN-gamma in response to injections of TLR9 agonists
• there is also a reduction in IFN-gamma production upon LPS administration
• mice fail to make IL-12p40 in response to the TLR9 agonist CpG-containing oligodeoxynucleotide ODN1826
• IL-12p40 production is reduced 5- to 30- fold in response to agonists to TLR1 +TLR2, TLR4, TLR5, TLR7, or TLR9
• circulating levels of IL-6 one hour after TLR9 stimulation is half that in wild-type controls
• DCs fail to secrete cytokines in response to TLR9 agonists
• nave antigen-specific T cells expand at a much slower rate when transferred into these mice with cognate antigen and TLR9 agonist

homeostasis/metabolism
• mice fail to make IL-12p40 in response to the TLR9 agonist CpG-containing oligodeoxynucleotide ODN1826
• IL-12p40 production is reduced 5- to 30- fold in response to agonists to TLR1 +TLR2, TLR4, TLR5, TLR7, or TLR9
• circulating levels of IL-6 one hour after TLR9 stimulation is half that in wild-type controls

hematopoietic system
• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice
• maturation markers on DCs such as I-Ab, CD80, and CD86 have several fold lower expression than in controls
• less Th1 T cells develop when nave antigen-specific T cells are transferred into these mice with cognate antigen and a TLR9 agonist
• antigen specific IgG1 levels are lower by almost an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist
• antigen specific IgG2b levels are lower by an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist
• antigen specific IgG2c levels are lower by several orders of magnitude than controls after immunization with OVA-peptide and TLR9 agonist
• NK cells in vivo make much several fold less IFN-gamma in response to injections of TLR9 agonists
• there is also a reduction in IFN-gamma production upon LPS administration

cellular
• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice
• maturation markers on DCs such as I-Ab, CD80, and CD86 have several fold lower expression than in controls




Genotype
MGI:5441610
cn2
Allelic
Composition
Rptortm1Ahir/Rptortm1Ahir
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
B6.Cg-Rptortm1Ahir Tg(Itgax-cre)1-1Reiz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rptortm1Ahir mutation (0 available); any Rptor mutation (87 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• DSS-treated mice exhibit enhanced colitis with exaggerated body weight loss and reduction of colon length compared with control mice
• expanded CD8+ splenic and CD11c+CD11b+ intestinal conventional dendritic cells
• however, the total number of conventional and plasmacytoid dendritic cells is normal

digestive/alimentary system
• exaggerated reduction of colon length in DSS-treated mice
• DSS-treated mice exhibit enhanced colitis with exaggerated body weight loss and reduction of colon length compared with control mice

growth/size/body
• exaggerated in DSS-treated mice

hematopoietic system
• expanded CD8+ splenic and CD11c+CD11b+ intestinal conventional dendritic cells
• however, the total number of conventional and plasmacytoid dendritic cells is normal




Genotype
MGI:6452099
cn3
Allelic
Composition
Pld4tm1.1Nemz/Pld4tm1.1Nemz
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4tm1.1Nemz mutation (0 available); any Pld4 mutation (18 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

immune system
• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages




Genotype
MGI:4417844
cn4
Allelic
Composition
Il15ratm1Ama/Il15ratm2.1Ama
Lyz2tm1(cre)Ifo/0
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Ama mutation (1 available); any Il15ra mutation (30 available)
Il15ratm2.1Ama mutation (1 available); any Il15ra mutation (30 available)
Lyz2tm1(cre)Ifo mutation (13 available); any Lyz2 mutation (25 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• decrease in the numbers of adoptively transferred transgenic CD8+ T cells compared to controls by 30 days after immunization

hematopoietic system
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood




Genotype
MGI:5547520
cn5
Allelic
Composition
Myd88tm1Defr/Myd88tm1Defr
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Defr mutation (3 available); any Myd88 mutation (43 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
Tnip1tm1.2Ama mutation (0 available); any Tnip1 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• unlike Tnip1tm1.1Ama/Tnip1tm1.1Ama Tg(Itgax-cre)1-1Reiz hematopoietic stem cells used in transplantation experiments, hematopoietic stem cells do not alter susceptibility to IMQ-induced psoriasis

immune system
N
• unlike Tnip1tm1.1Ama/Tnip1tm1.1Ama Tg(Itgax-cre)1-1Reiz mice, mice exhibit normal spleen mass, myeloid cell numbers and activated T lymphocyte




Genotype
MGI:3763283
cn6
Allelic
Composition
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpjtm1Hon mutation (2 available); any Rbpj mutation (201 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• splenic dendritic cell (DC) population is decreased similarly to bone marrow deletion of Rbpj; ratio of CD8-/CD8+ dendritic cells is significantly decreased, resulting from 3-fold decrease in numbers of CD8- DCs with normal numbers of CD8+ DCs
• frequency of cytokine-secreting CD8- DCs in cultured splenocytes is decreased 3-fold compared to controls whereas cytokine-secreting CD8+ DCs is unchanged

immune system
• splenic dendritic cell (DC) population is decreased similarly to bone marrow deletion of Rbpj; ratio of CD8-/CD8+ dendritic cells is significantly decreased, resulting from 3-fold decrease in numbers of CD8- DCs with normal numbers of CD8+ DCs
• frequency of cytokine-secreting CD8- DCs in cultured splenocytes is decreased 3-fold compared to controls whereas cytokine-secreting CD8+ DCs is unchanged
• in response to TLR activation, dendritic cell cytokine production is decreased compared to controls




Genotype
MGI:5314240
cn7
Allelic
Composition
Syktm1.2Tara/Syktm1.2Tara
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.2Tara mutation (1 available); any Syk mutation (31 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal perinatal survival

immune system
N
• mice exhibit normal lymphatic vessels

homeostasis/metabolism
N
• mice do not exhibit edema




Genotype
MGI:5545813
cn8
Allelic
Composition
Lyntm1.1Calo/Lyntm1.1Calo
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1.1Calo mutation (0 available); any Lyn mutation (50 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lupus-like autoimmune disease in Lyntm1Sor/Lyntm1Sor and Lyntm1.1Calo/Lyntm1.1Calo Top2aGt(PST14568)Mfgc/0 mice

growth/size/body
• severe splenomegaly starting at 6 months of age
• spleens are 16- and 7.9-fold larger than those in controls and mice homozygous for Lyntm1Sor, respectively

mortality/aging
• average survival time of 8 months

immune system
• severe splenomegaly starting at 6 months of age
• spleens are 16- and 7.9-fold larger than those in controls and mice homozygous for Lyntm1Sor, respectively
• dramatic expansion of myeloid compartment in the spleen and lymph nodes
• myeloid proliferations occurs earlier than in mice homozygous for Lyntm1Sor
• increase in the numbers of CD11chi MHCII+ conventional DCs and CD11clo B220+ Ly6C+ plasmacytoid DCs in the spleen and lymph nodes over time
• increased numbers of monocytes/macrophages in the spleen and lymph nodes at 4 months of age
• in the spleen and lymph nodes at 4 months of age
• increase in the number of CD19lo/- CD138hi plasma cells in the spleen
• high numbers of CD44hi CD62Llo/- effector T cells and CD69+ T cells
• in secondary lymphoid organs
• in the spleen and lymph nodes at 4 months of age
• myeloid cells are hyperresponsive to LPS
• in secondary lymphoid organs
• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age
• high levels of circulating B-cell activating factor
• increased levels of a number of chemokines at 6 months of age
• increase in lymph node size and cellularity as early as 4 months of age, mainly due to increased numbers of T cells myeloid cells and dendritic cells
• following exposure to Brefeldin A and LPS, splenic dendritic cells produce high levels of inflammatory cytokines
• CD11chi DCs are hyperresponsive to cytokine stimulation
• high levels of autoreactive antibodies in the serum
• by 8 months of age, 60-70% of mice display severe leukocyte infiltration in the lungs, liver, and skin
• enlarged glomeruli and increased leukocyte infiltration indicative of glomerulonephritis at 6 months of age
• abundant leukocyte infiltration in the interstitial tissue at 6 months of age

integument
• develop macroscopic skin lesions starting around 6 months of age

renal/urinary system
• enlarged glomeruli and increased leukocyte infiltration indicative of glomerulonephritis at 6 months of age
• abundant leukocyte infiltration in the interstitial tissue at 6 months of age
• deposition of C3 in the glomeruli

homeostasis/metabolism
• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age
• high levels of circulating B-cell activating factor
• increased levels of a number of chemokines at 6 months of age

liver/biliary system

respiratory system

hematopoietic system
• severe splenomegaly starting at 6 months of age
• spleens are 16- and 7.9-fold larger than those in controls and mice homozygous for Lyntm1Sor, respectively
• dramatic expansion of myeloid compartment in the spleen and lymph nodes
• myeloid proliferations occurs earlier than in mice homozygous for Lyntm1Sor
• increase in the numbers of CD11chi MHCII+ conventional DCs and CD11clo B220+ Ly6C+ plasmacytoid DCs in the spleen and lymph nodes over time
• increased numbers of monocytes/macrophages in the spleen and lymph nodes at 4 months of age
• in the spleen and lymph nodes at 4 months of age
• increase in the number of CD19lo/- CD138hi plasma cells in the spleen
• high numbers of CD44hi CD62Llo/- effector T cells and CD69+ T cells
• in secondary lymphoid organs
• in the spleen and lymph nodes at 4 months of age
• myeloid cells are hyperresponsive to LPS
• in secondary lymphoid organs




Genotype
MGI:5545814
cn9
Allelic
Composition
Lyntm1.1Calo/Lyntm1.1Calo
Myd88tm1Defr/Myd88tm1Defr
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1.1Calo mutation (0 available); any Lyn mutation (50 available)
Myd88tm1Defr mutation (3 available); any Myd88 mutation (43 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• inflammation seen in mutant mice wild-type for Myd88 is reversed and mice do not develop autoantibodies

renal/urinary system
N
• kidneys are of normal size and cellularity and show no signs of inflammation




Genotype
MGI:5563543
cn10
Allelic
Composition
Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb1tm1.1Ttg mutation (0 available); any Hmgb1 mutation (12 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following lipopolysaccharide stimulation
• following lipopolysaccharide stimulation

homeostasis/metabolism
• following lipopolysaccharide stimulation
• following lipopolysaccharide stimulation




Genotype
MGI:5570963
cn11
Allelic
Composition
Cx3cr1tm3(DTR)Litt/Cx3cr1tm3(DTR)Litt
Tg(Itgax-cre)1-1Reiz/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm3(DTR)Litt mutation (1 available); any Cx3cr1 mutation (33 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice treated with diphtheria toxin (DTR) and infected with non-invasive Salmonella exhibit decreased bacterial titers in the mesenteric lymph nodes as compared to mice carrying Cx3cr1tm3(DTR)Litt in the absence of cre recombinase




Genotype
MGI:6192275
cn12
Allelic
Composition
Braftm1Mmcm/Braftm1Mmcm
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Mmcm mutation (3 available); any Braf mutation (44 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• severe hepatosplenomegaly

mortality/aging
• decrease in lifespan

immune system
• severe hepatosplenomegaly
• lesions are associated with massive increase of MHC II+CD11c+ dendritic cells
• expansion of blood circulating dendritic cell precursors and blood circulating dendritic cells
• histiocytic infiltrates in the skin, liver, spleen, and lungs by 8 weeks of age, resulting in a broad destruction of tissue architecture by 16 weeks of age
• histiocytic lesions exhibit classical granulomatous organization, including multinucleated giant cell formation
• granuloma lesions contain massive CD11c+ langerin+ infiltrates, a large number of macrophages, NK cells, B cells, and T cells, with a specific accumulation of regulatory T cells
• local fibrotic response is seen within the granulomas and surrounding stroma
• mice rapidly develop an aggressive Langerhans-cells histiocytosis-like disease with 100% penetrance
• granuloma lesions are associated with an increase in several chemokines and cytokines (Ccl2, Ccl15, Il6, Il10, IFN-gamma, and TGF-beta) indicative of a local cytokine storm

hematopoietic system
• severe hepatosplenomegaly
• severe anemia
• lesions are associated with massive increase of MHC II+CD11c+ dendritic cells
• expansion of blood circulating dendritic cell precursors and blood circulating dendritic cells

growth/size/body
• severe hepatosplenomegaly

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Langerhans-cell histiocytosis DOID:2571 OMIM:246400
OMIM:604856
J:211690




Genotype
MGI:5515639
cn13
Allelic
Composition
Il6tm1Kopf/Il6+
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (29 available)
Prdm1tm1Clme mutation (1 available); any Prdm1 mutation (47 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not develop autoantibodies, they mount an antibody response indistinguishable from control mice to NP-CGG, dendritic cells express the same level of IL-6 as dendritic cells from control mice after LPS stimulation, and show normal levels of follicular T helper cells and germinal cells in the spleen




Genotype
MGI:5545809
cn14
Allelic
Composition
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm3Rsjo mutation (3 available); any Hif1a mutation (37 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• bone marrow derived dendritic cells (BMDCs) cultured under hypoxic conditions (1% oxygen) show upregulation of maturation markers such as MHCII, CD86, with CD80 only slightly enhanced; control BMDCs grown in hypoxic conditions show similar enhanced maturation markers
• stimulation by LPS does not further enhance expression of maturation markers as it does in BMDCs grown under normoxic conditions
• production of Il12p70, Il10, Il6, and Il23 is decreased in mutant and control BMDCs under hypoxic conditions, with Il22 upregulated compared to normoxic cells; mutant and control BMDCs generated under hypoxic conditions produce less TNFalpha and Il-1beta than cells under normoxic conditions
• fewer mutant BMDCs generated under hypoxic conditions migrate toward CCL19 in a transwell chamber assay than control cells grown under hypoxic conditions; migration toward CXCL12 is not different from controls under hypoxic or normoxic conditions
• mutant BMDCs generated under hypoxic conditions injected into mouse footpads show reduced migration to popliteal lymph nodes compared to control BMDCs grown under hypoxic conditions; mutant and control BMDCs generated under normoxic conditions migrate equally well to draining lymph nodes while control cells generated under hypoxia display enhanced migration relative to control cells from normoxic cultures, indicating migration under under hypoxic conditons is dependent on Hif1a
• bone marrow dendritic cells (BMDCs) differentiated under hypoxic conditions display reduced growth (proliferation) compared to control cells grown in hypoxia or mutant and control cells grown under normoxic (21% oxygen) conditions

cellular
• reduced amounts of ATP are detected in lysates of mutant BMDCs cultured under hypoxic conditions compared to control cells under hypoxia suggesting an energy metabolism defect with Hif1a deletion
• fewer mutant BMDCs generated under hypoxic conditions migrate toward CCL19 in a transwell chamber assay than control cells grown under hypoxic conditions; migration toward CXCL12 is not different from controls under hypoxic or normoxic conditions
• mutant BMDCs generated under hypoxic conditions injected into mouse footpads show reduced migration to popliteal lymph nodes compared to control BMDCs grown under hypoxic conditions; mutant and control BMDCs generated under normoxic conditions migrate equally well to draining lymph nodes while control cells generated under hypoxia display enhanced migration relative to control cells from normoxic cultures, indicating migration under under hypoxic conditons is dependent on Hif1a

hematopoietic system
• fewer mutant BMDCs generated under hypoxic conditions migrate toward CCL19 in a transwell chamber assay than control cells grown under hypoxic conditions; migration toward CXCL12 is not different from controls under hypoxic or normoxic conditions
• mutant BMDCs generated under hypoxic conditions injected into mouse footpads show reduced migration to popliteal lymph nodes compared to control BMDCs grown under hypoxic conditions; mutant and control BMDCs generated under normoxic conditions migrate equally well to draining lymph nodes while control cells generated under hypoxia display enhanced migration relative to control cells from normoxic cultures, indicating migration under under hypoxic conditons is dependent on Hif1a
• bone marrow dendritic cells (BMDCs) differentiated under hypoxic conditions display reduced growth (proliferation) compared to control cells grown in hypoxia or mutant and control cells grown under normoxic (21% oxygen) conditions




Genotype
MGI:5515634
cn15
Allelic
Composition
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1tm1Clme mutation (1 available); any Prdm1 mutation (47 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells
• more spontaneous germinal center B cells
• increase in the percentage and number of follicular T helper cells
• more germinal centers in the spleen
• total number of splenocytes are increased in females but not males
• enhanced immune response after NP-CGG immunization with an increased high-affinity anti-NP IgG response, an increase in the number of germinal center B cells, and an increase in the number of total germinal cells and antigen-specific germinal cells
• enhanced germinal center response in young mice
• total serum immunoglobulin levels are increased in females but not males
• kidney deposition of IgG in 10 month old females
• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls
• increase in production of IL-6 by splenic dendritic cells and by bone marrow derived dendritic cells after LPS stimulation in females but not males
• females, but not males, develop autoantibodies as early as 4-5 months of age, including anti-nuclear antibodies, anti-double stranded dNA, and anti-ENA5, which are all IgG
• IgG2b is the major isotype of anti-dsDNA antibodies
• inflammatory infiltrates in 10 month old females

renal/urinary system
• proteinuria in 10 month old females
• inflammatory infiltrates in 10 month old females
• kidney deposition of IgG in 10 month old females
• mesangial cell proliferation in 10 month old females

hematopoietic system
• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells
• more spontaneous germinal center B cells
• increase in the percentage and number of follicular T helper cells
• more germinal centers in the spleen
• total number of splenocytes are increased in females but not males
• enhanced germinal center response in young mice
• total serum immunoglobulin levels are increased in females but not males
• kidney deposition of IgG in 10 month old females
• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls

homeostasis/metabolism
• proteinuria in 10 month old females




Genotype
MGI:6393530
cn16
Allelic
Composition
Rab32tm1c(KOMP)Wtsi/Rab32tm1c(KOMP)Wtsi
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab32tm1c(KOMP)Wtsi mutation (0 available); any Rab32 mutation (13 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• more severely shortened colon during dextran sodium sulfate (DSS)-induced colitis
• increased bacterial load in mesenteric lymph node and colon after DSS administration
• increased, and earlier onset of, weight loss after dextran sodium sulfate (DSS) administration
• increased incidence of diarrhea and rectal bleeding after DSS administration
• more severely shortened colon after DSS administration
• increased intestinal tissue damage after DSS administration
• after dextran sodium sulfate (DSS) administration

immune system
• increased, and earlier onset of, weight loss after dextran sodium sulfate (DSS) administration
• increased incidence of diarrhea and rectal bleeding after DSS administration
• more severely shortened colon after DSS administration
• increased intestinal tissue damage after DSS administration
• increased bacterial load in mesenteric lymph node and colon after DSS administration
• after dextran sodium sulfate (DSS) administration
• increased Cd11b+ Ly6g+ neutrophil frequency during dextran sodium sulfate (DSS)-induced colitis
• increased expression of Il1a, Il1b, Il6, Cxcl1, Cxcl2, Csf3 during dextran sodium sulfate (DSS)-induced colitis
• normal expression of Il4, Il10, Il12, Il17, Tnfa, Gzma, Gzmb, Stat4, Gata3, Rorc, Foxp3 during DSS-induced colitis
• increased pathogen load in liver and spleen after intravenous injection of L. monocytogenes (J:231298)
• increased bacterial load in mesenteric lymph node and colon during dextran sodium sulfate (DSS)-induced colitis (J:267497)
• normal bacterial load in spleen during DSS-induced colitis (J:267497)

hematopoietic system
N
• normal Cd3+, Cd4+ and Cd8+ T cells during dextran sodium sulfate (DSS)-induced colitis during dextran sodium sulfate (DSS)-induced colitis
• normal Cd80, Cd86 and Mog expression in Cd11c+ bone marrow dendritic cells (BMDCs) during DSS-induced colitis
• increased Cd11b+ Ly6g+ neutrophil frequency during dextran sodium sulfate (DSS)-induced colitis

mortality/aging
• after dextran sodium sulfate (DSS) administration




Genotype
MGI:5897848
cn17
Allelic
Composition
Zranb1tm1c(EUCOMM)Hmgu/Zranb1tm1c(EUCOMM)Hmgu
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6N * CBA
Cell Lines HEPD0538_8_D07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre)1-1Reiz mutation (3 available)
Zranb1tm1c(EUCOMM)Hmgu mutation (0 available); any Zranb1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal dendritic cell development, migration and maturation
• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin
• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin
• bone marrow-derived dendritic cells induce a 2- to 3-fold decrease in LPS-stimulated differentiation of CD4+ T cells into Th1 and Th17 cells
• however, induction of regulatory T cells is normal
• mice treated with MOG(35-55) along with pertussis toxin exhibit delayed onset, decreased clinical score and reduced inflammation compared with wild-type mice

hematopoietic system
• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin
• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin




Genotype
MGI:4417842
cn18
Allelic
Composition
Il15ratm1Ama/Il15ratm2.1Ama
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ratm1Ama mutation (1 available); any Il15ra mutation (30 available)
Il15ratm2.1Ama mutation (1 available); any Il15ra mutation (30 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
• marked decrease in the ratio of CD62Lhi to CD62Llo memory phenotype CD8+ T cells
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride

immune system
• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow
• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow
• about half the number of NK cells in the spleen, lymph node, liver, and lung
• but no decrease is seen in the bone marrow
• marked decrease in the ratio of CD62Lhi to CD62Llo memory phenotype CD8+ T cells
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood
• marked decrease in the number of CD62Lhi memory phenotype CD8+ T cells
• decrease in proliferation of CD27+ CD11b+ cells
• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride




Genotype
MGI:6196862
cn19
Allelic
Composition
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce/Gt(ROSA)26Sor+
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce mutation (0 available); any Gt(ROSA)26Sor mutation (741 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice are runted

hematopoietic system
• mice exhibit elevation of neutrophils in tissues
• mice exhibit elevation of monocytes in tissues

immune system
• mice exhibit elevation of neutrophils in tissues
• mice exhibit elevation of monocytes in tissues

skeleton
N
• mice do not develop joint swellings




Genotype
MGI:5903128
cn20
Allelic
Composition
Cxcr5tm1.1Namt/Cxcr5tm1.1Namt
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr5tm1.1Namt mutation (0 available); any Cxcr5 mutation (17 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal secondary lymphoid tissue formation
• impaired chemotaxis toward CXCL13 in conventional dendritic cell
• marginal reduction in the follicle dendritic cells in the spleen
• following oral administration of scrapie prion proteins, mice exhibit reduced follicular dendritic cell-associated accumulation of prion protein in the spleen compared with control mice
• splenectomy before oral prion exposure does not alter susceptibility
• however, prion disease susceptibility is normal when infection is established directly within the CNS

cellular
• impaired chemotaxis toward CXCL13 in conventional dendritic cell

hematopoietic system
• impaired chemotaxis toward CXCL13 in conventional dendritic cell




Genotype
MGI:5467386
cn21
Allelic
Composition
Pycardtm1Ayaz/Pycardtm1Ayaz
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycardtm1Ayaz mutation (0 available); any Pycard mutation (6 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit normal skin tumor formation




Genotype
MGI:5903129
cn22
Allelic
Composition
Cxcr5tm1.1Namt/Cxcr5tm1.1Namt
Tg(Itgax-cre)1-1Reiz/0
Tg(Prnp)a20Cwe/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr5tm1.1Namt mutation (0 available); any Cxcr5 mutation (17 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
Tg(Prnp)a20Cwe mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following oral administration of scrapie prion proteins, mice exhibit reduced follicular cell-associated prion infectivity in the spleen compared with control mice
• however, accumulation of prions in medial lymph nodes is normal




Genotype
MGI:5547518
cn23
Allelic
Composition
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre)1-1Reiz mutation (3 available)
Tnip1tm1.2Ama mutation (0 available); any Tnip1 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• by 3 to 4 months with accumulation of myeloid and memory T cells

immune system
• by 3 to 4 months with accumulation of myeloid and memory T cells
• increased CD11b+Gr1+ myeloid cells
• CD4+ and CD8+ memory T cells
• by 3 to 4 months with accumulation of myeloid and memory T cells
• from bone marrow-derived dendritic cells stimulated with LPS
• from bone marrow-derived dendritic cells stimulated with LPS
• from bone marrow-derived dendritic cells stimulated with LPS
• from bone marrow-derived dendritic cells stimulated with LPS

hematopoietic system
• by 3 to 4 months with accumulation of myeloid and memory T cells
• increased CD11b+Gr1+ myeloid cells
• CD4+ and CD8+ memory T cells
• hematopoietic stem cells transplanted into irradiated recipient mice exhibit increased susceptibility to IMQ-induced psoriasis compared with control cells




Genotype
MGI:5696542
cn24
Allelic
Composition
Atg16l1tm1c(EUCOMM)Wtsi/Atg16l1tm1c(EUCOMM)Wtsi
Tg(Itgax-cre)1-1Reiz/?
Genetic
Background
involves: C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1tm1c(EUCOMM)Wtsi mutation (0 available); any Atg16l1 mutation (30 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• normal up-regulation of expression of autophagy regulators in intestinal epithelia, the mesenchymal compartment, and in cecal patches after infection with Salmonella typhimurium as seen in controls

immune system
N
• normal cytokine response by intestinal epithelial cells to infection




Genotype
MGI:6401463
cn25
Allelic
Composition
Ddx41tm1.1Arte/Ddx41tm1.1Arte
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx41tm1.1Arte mutation (0 available); any Ddx41 mutation (36 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• normal percentage dendritic cells (DCs) in peripheral blood
• normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP

immune system
N
• normal percentage dendritic cells (DCs) in peripheral blood
• normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP
• lack of interferon beta surge in BMDCs from MLV (murine leukemia virus) or HIV-infected mice
• 5x higher virus titer in spleen 16 days after inoculation of newborn pups with MLV (murine leukemia virus)
• higher infection levels in draining lymph node after subcutaneous inoculation with MLV (murine leukemia virus)
• normal interferon beta surge in bone marrow-derived macrophages (BMDMs) from MLV (murine leukemia virus)-infected mice




Genotype
MGI:6156916
cn26
Allelic
Composition
Sec22btm1c(EUCOMM)Wtsi/Sec22btm1c(EUCOMM)Wtsi
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec22btm1c(EUCOMM)Wtsi mutation (0 available); any Sec22b mutation (11 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• development of dendritic cell (DC), myeloid cell, T cell and other lymphoid populations, and thymocyte differentiation and T cell activation state
• dendritic cell (DC) development, cytokine response to toll-like receptor (Tlr) stimulation, direct antigen presentation, and endocytic antigen uptake
• in vivo cross-presentation of soluble antigens
• in vitro cross-presentation of soluble or particulate antigens using splenic Cd11c+ DCs




Genotype
MGI:5486200
cn27
Allelic
Composition
Id2tm2.1Gtbz/Id2tm2.1Gtbz
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm2.1Gtbz mutation (0 available); any Id2 mutation (16 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• in reconstitution assays, bone marrow cells are able to generate CD8alpha+ dendritic cells

immune system
N
• in reconstitution assays, bone marrow cells are able to generate CD8alpha+ dendritic cells




Genotype
MGI:5007897
cn28
Allelic
Composition
Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tg(Itgax-cre)1-1Reiz/0
Tyrc-2J/Tyrc-2J
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm2.1Lien mutation (0 available); any Ifnb1 mutation (15 available)
Tg(Itgax-cre)1-1Reiz mutation (3 available)
Tyrc-2J mutation (21 available); any Tyr mutation (357 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal response to L. monocytogenes infection





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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory