Cx3cr1^{tm3(Hbegf)Litt}
Targeted Allele Detail

Summary

• Symbol: Cx3cr1^{tm3(Hbegf)Litt}
• Name: C-X3-C motif chemokine receptor 1; targeted mutation 3, Dan R Littman
• MGI ID: MGI:5569511
• Synonyms: CX3CR1-STOP-DTR, Cx3cr1^tm3(DTR)Litt
• Gene: Cx3cr1 Location: Chr9:119877749-119897362 bp, - strand Genetic Position: Chr9, 71.37 cM
• Alliance: Cx3cr1^{tm3(Hbegf)Litt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210086
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Cx3cr1^{tm3(Hbegf)Litt} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: The targeting vector containing a loxP-Stop-loxP-diptheria toxin receptor (DTR)-IRES-YFP cassette was inserted into exon 1. (J:101977, J:210086)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cx3cr1 Mutation: 45 strains or lines available

References

• Original: J:210086 Diehl GE, et al., Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature. 2013 Feb 7;494(7435):116-20
• All: 13 reference(s)