Hmgb1^tm1.1Ttg
Targeted Allele Detail

Summary

• Symbol: Hmgb1^tm1.1Ttg
• Name: high mobility group box 1; targeted mutation 1.1, Tadatsugu Taniguchi
• MGI ID: MGI:5563518
• Synonyms: Hmgb1^f
• Gene: Hmgb1 Location: Chr5:148983512-148989867 bp, - strand Genetic Position: Chr5, 89.18 cM
• Alliance: Hmgb1^tm1.1Ttg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205499
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-neo-loxP cassette was inserted upstream of exon 2 and a third loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette. (J:205499)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb1 Mutation: 15 strains or lines available

References

• Original: J:205499 Yanai H, et al., Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20699-704
• All: 12 reference(s)