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Hmgb1 Gene Detail
Summary
  • Symbol
    Hmgb1
  • Name
    high mobility group box 1
  • Synonyms
    amphoterin, DEF, Hmg1, HMG-1, p30, SBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96113
    NCBI Gene: 15289
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:148983512-148989867 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 89.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    25
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96113
 protein coding gene Chr5:148983512-149121299 (-)
129S1/SvImJ ENSMUSG00200010646
 protein coding gene Chr5:142818748-142825563 (-)
129S1/SvImJ ENSMUSG00200006695
 protein coding gene Chr2:110638049-110639391 (-)
A/J ENSMUSG00195042033
 protein coding gene Chr15:71137921-71139232 (-)
A/J ENSMUSG00195004743
 protein coding gene Chr5:142428181-142434995 (-)
AKR/J ENSMUSG00220051598
 protein coding gene Chr15:71058487-71059779 (-)
AKR/J ENSMUSG00220004850
 protein coding gene Chr2:110596867-110598152 (-)
AKR/J ENSMUSG00220014774
 protein coding gene Chr5:141431814-141438633 (-)
BALB/cJ ENSMUSG00180003097
 protein coding gene Chr5:142830552-142837366 (-)
BALB/cJ ENSMUSG00180022463
 protein coding gene Chr15:70910332-70911742 (-)
C3H/HeJ ENSMUSG00175010869
 protein coding gene Chr5:144671422-144678235 (-)
C57BL/6NJ ENSMUSG00215023903
 protein coding gene Chr2:110652062-110653355 (-)
C57BL/6NJ ENSMUSG00215047653
 protein coding gene Chr15:70967554-70968865 (-)
C57BL/6NJ ENSMUSG00215000049
 protein coding gene Chr5:142374450-142381259 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028049
 protein coding gene Chr5:142614575-142746981 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210000443
 protein coding gene Chr5:143564654-143571463 (-)
DBA/2J ENSMUSG00185037569
 protein coding gene Chr2:19566213-19567091 (-)
DBA/2J ENSMUSG00185037317
 protein coding gene Chr5:146534805-146541614 (-)
FVB/NJ ENSMUSG00205010109
 protein coding gene Chr15:70731142-70732434 (-)
FVB/NJ ENSMUSG00205023771
 protein coding gene Chr5:142209468-142216281 (-)
JF1/MsJ ENSUMUG00000030338
 protein coding gene Chr5:149027242-149034034 (-)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190014627
 protein coding gene Chr2:110731428-110732748 (-)
NOD/ShiLtJ ENSMUSG00190005474
 protein coding gene Chr5:142176493-142183312 (-)
NZO/HlLtJ ENSMUSG00225007872
 protein coding gene Chr5:158280634-158287443 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005013751
 protein coding gene Chr5:144957707-144964527 (-)



Homology
more
  • Human Ortholog
    HMGB1, high mobility group box 1
  • Vertebrate Orthologs
    11
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGB1, high mobility group box 1
  • Synonyms
    HMG-1, HMG1, HMG3, SBP-1
  • Links
    NCBI Gene ID: 3146
    UniProt: P09429

  • Chr Location
    13q12.3; chr13:30456704-30618872 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HMGB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 5 alleles in 9 genetic backgrounds
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial or complete neonatal lethality due to hypoglycemia depending on the strain background, with open eyelids at birth, atelectasis, and lethargy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    245
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    937
  • Tissues
    180
  • cDNA Data
    33
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15289 NCBI Gene Model | MGI Sequence Detail 6356 C57BL/6J ±  kb
    transcript NM_001313894 RefSeq | MGI Sequence Detail 3035 ZRU/MplStud  
    polypeptide P63158 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 4
      cDNA 39
      Primer pair 7
      Other 3
      Antibodies 7

      Microarray probesets 25
    Other
    Accession IDs
    less
    MGD-MRK-10748
    References
    more
    • Summaries
      All 400
      Developmental Gene Expression 32
      Gene Ontology 37
      Phenotypes 79
    • Earliest
      J:384522 Rauvala H, et al., The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons. J Cell Biol. 1988 Dec;107(6 Pt 1):2293-305
    • Latest
      J:386394 Yamada C, et al., Porphyromonas gingivalis-Derived Virulence Lipids Accelerate Osteoclastogenesis Independently of High Mobility Group Box Protein-1 Canonical Signaling. Mol Oral Microbiol. 2026 Apr;41(2):85-93
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory