Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables cytokine activity; nucleic acid binding activity; and protein kinase regulator activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of signal transduction; and positive regulation of sprouting angiogenesis. Acts upstream of or within several processes, including cellular response to interleukin-7; positive regulation of cell differentiation; and positive regulation of macromolecule metabolic process. Located in several cellular components, including early endosome; extracellular space; and neuron projection. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and congestive heart failure. Orthologous to human HMGB1 (high mobility group box 1).