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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmgb1tm1.1Ttg
targeted mutation 1.1, Tadatsugu Taniguchi
MGI:5563518
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd MGI:5563539
cn2
 		Hmgb1tm1.1Ttg/Hmgb1tm1.2Ttg
Tg(CAG-cre)13Miya/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:5563525
cn3
 		Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Tg(Itgax-cre)1-1Reiz/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5563543
cn4
 		Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:5563542


Genotype
MGI:5563539
cn1
Allelic
Composition		 Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb1tm1.1Ttg mutation (0 available); any Hmgb1 mutation (15 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:205499 )
N
• normal myeloid lineage and in vitro M1 and M2 macrophage differentiation
abnormal macrophage physiology ( J:205499 )
• decrease in autophagosome formation in response to lipopolysaccharide injection or bacterial infection
increased macrophage apoptosis ( J:205499 )
• with TLR stimulation and pan-caspase inhibition treatments
impaired macrophage phagocytosis ( J:205499 )
• decrease in generation of LC3-II by peritonela macrophages following infection with L. monocytogenes indicates impaired induction of autophagy

immune system
abnormal macrophage physiology ( J:205499 )
• decrease in autophagosome formation in response to lipopolysaccharide injection or bacterial infection
increased macrophage apoptosis ( J:205499 )
• with TLR stimulation and pan-caspase inhibition treatments
impaired macrophage phagocytosis ( J:205499 )
• decrease in generation of LC3-II by peritonela macrophages following infection with L. monocytogenes indicates impaired induction of autophagy
increased circulating interleukin-1 beta level ( J:205499 )
• elevated levels of Il1 beta and IL18 in LPS stimulated mice suggest hyperactivation of the inflammasome pathway
increased circulating interleukin-18 level ( J:205499 )
• elevated levels of Il1 beta and IL18 in LPS stimulated mice suggest hyperactivation of the inflammasome pathway
increased interleukin-1 beta secretion ( J:205499 )
• in cultured macrophages stimulated with LPS and ATP
increased interleukin-18 secretion ( J:205499 )
• in cultured macrophages stimulated with LPS and ATP
increased susceptibility to endotoxin shock ( J:205499 )
• along with massive lung tissue destruction upon lipopoysaccharide injection

homeostasis/metabolism
increased circulating interleukin-1 beta level ( J:205499 )
• elevated levels of Il1 beta and IL18 in LPS stimulated mice suggest hyperactivation of the inflammasome pathway
increased circulating interleukin-18 level ( J:205499 )
• elevated levels of Il1 beta and IL18 in LPS stimulated mice suggest hyperactivation of the inflammasome pathway

cellular
increased sensitivity to induced cell death ( J:205499 )
• higher in vitro macrophage cell death after lipopolysaccharide injection
increased macrophage apoptosis ( J:205499 )
• with TLR stimulation and pan-caspase inhibition treatments
impaired macrophage phagocytosis ( J:205499 )
• decrease in generation of LC3-II by peritonela macrophages following infection with L. monocytogenes indicates impaired induction of autophagy




Genotype
MGI:5563525
cn2
Allelic
Composition		 Hmgb1tm1.1Ttg/Hmgb1tm1.2Ttg
Tg(CAG-cre)13Miya/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb1tm1.1Ttg mutation (0 available); any Hmgb1 mutation (15 available)
Hmgb1tm1.2Ttg mutation (0 available); any Hmgb1 mutation (15 available)
Tg(CAG-cre)13Miya mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:205499 )
• die shortly after birth




Genotype
MGI:5563543
cn3
Allelic
Composition		 Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb1tm1.1Ttg mutation (0 available); any Hmgb1 mutation (15 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased circulating interleukin-1 beta level ( J:205499 )
• following lipopolysaccharide stimulation
increased circulating interleukin-18 level ( J:205499 )
• following lipopolysaccharide stimulation

homeostasis/metabolism
increased circulating interleukin-1 beta level ( J:205499 )
• following lipopolysaccharide stimulation
increased circulating interleukin-18 level ( J:205499 )
• following lipopolysaccharide stimulation




Genotype
MGI:5563542
cn4
Allelic
Composition		 Hmgb1tm1.1Ttg/Hmgb1tm1.1Ttg
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb1tm1.1Ttg mutation (0 available); any Hmgb1 mutation (15 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased circulating interleukin-1 beta level ( J:205499 )
• following lipopolysaccharide stimulation
increased circulating interleukin-18 level ( J:205499 )
• following lipopolysaccharide stimulation

homeostasis/metabolism
increased circulating interleukin-1 beta level ( J:205499 )
• following lipopolysaccharide stimulation
increased circulating interleukin-18 level ( J:205499 )
• following lipopolysaccharide stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory