Atg16l1^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Atg16l1^{tm1c(EUCOMM)Wtsi}
• Name: autophagy related 16 like 1; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5638694
• Synonyms: Agt16l1^flox, Atg16l1^f
• Gene: Atg16l1 Location: Chr1:87683730-87720150 bp, + strand Genetic Position: Chr1, 44.44 cM
• Alliance: Atg16l1^{tm1c(EUCOMM)Wtsi} page
• IMPC: Atg16l1 gene page

Mutation origin

• Mutant Cell Line: EPD0102_2_A02
• Germline Transmission: Earliest citation of germline transmission: J:221019
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt2
• Mutation details: The L1L2_gt2 cassette was inserted at position 87692620 of Chromosome 1 upstream of critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon at position 87693444. Exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. (J:221019)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atg16l1 Mutation: 46 strains or lines available

References

• Original: J:221019 Conway KL, et al., Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology. 2013 Dec;145(6):1347-57
• All: 37 reference(s)