All Phenotypes Atg16l1<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atg16l1^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5638694

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tcrd^tm1Mom/Tcrd^tm1Mom Tg(Vil1-cre)997Gum/0	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * SJL	MGI:7564089
cn2	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Pgr^tm2(cre)Lyd/Pgr⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6850681
cn3	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Defa6-icre)1Rsb/0	involves: C57BL/6	MGI:7564131
cn4	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Itgax-cre)1-1Reiz/?	involves: C57BL/6 * C57BL/6N * CBA	MGI:5696542
cn5	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/?	involves: C57BL/6J * C57BL/6N * SJL	MGI:5696541
cn6	Api5^em1Cad/Api5^em1Cad Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/0	involves: C57BL/6J * C57BL/6N * SJL	MGI:7564119
cn7	Api5^em1Cad/Api5⁺ Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/0	involves: C57BL/6J * C57BL/6N * SJL	MGI:7564126

Allelic Composition	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tcrd^tm1Mom/Tcrd^tm1Mom Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Atg16l1 mutation (44 available)
Tcrd^tm1Mom mutation (13 available); any Tcrd mutation (15 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

digestive/alimentary system

increased small intestinal crypt cell apoptosis ( J:340266 )

abnormal Paneth cell morphology ( J:340266 )

• remaining Paneth cells display abnormal lysozyme staining patterns

decreased Paneth cell number ( J:340266 )

• spontaneous Paneth cell loss in the absence of infection with murine norovirus

• however, goblet cell numbers are similar to controls

decreased small intestinal villus height ( J:340266 )

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

homeostasis/metabolism

abnormal cytokine level ( J:340266 )

• increased local levels of cytokine production in the small intestine

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

abnormal cytokine level ( J:340266 )

• increased local levels of cytokine production in the small intestine

cellular

increased small intestinal crypt cell apoptosis ( J:340266 )

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:340266 )

• remaining Paneth cells display abnormal lysozyme staining patterns

decreased Paneth cell number ( J:340266 )

• spontaneous Paneth cell loss in the absence of infection with murine norovirus

• however, goblet cell numbers are similar to controls

Allelic Composition	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Pgr^tm2(cre)Lyd/Pgr⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Atg16l1 mutation (44 available)
Pgr^tm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal decidualization ( J:287978 )

• after oil-induced artificial decidualization, stimulated uterine horns weigh more than unstimulated horns but remain smaller than stimulated horns of control mice

• stimulated horns fail to increase expression of the decidualization markers Bmp2 and Wnt4, endometrial stromal cells maintain a fibroblast morphology instead of assuming a rounded decidual cell morphology, and LC3B-II levels are downregulated, indicating impaired endometrial decidualization

impaired embryo implantation ( J:287978 )

• at 6 dpc, females have on average 2 fewer implantation sites than controls, indicating a decreased implantation rate

• however, no defects in ovulation or fertilization are found at 4 dpc

reduced female fertility ( J:287978 )

• when mated with wild-type males of proven fertility, females produce fewer pups than controls after their first parity

• over a 6 mo-period of continuous breeding, females have significantly fewer litters, smaller litter size, and reduced fecundity relative controls

• during natural mating, time to first litter (as measured by plug date to delivery date) is extended, suggesting that many females fail to get pregnant after their first mating

decreased litter size ( J:287978 )

• when mated with wild-type, females produce a significantly smaller litter size than controls

embryo

abnormal decidualization ( J:287978 )

• after oil-induced artificial decidualization, stimulated uterine horns weigh more than unstimulated horns but remain smaller than stimulated horns of control mice

Allelic Composition	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Defa6-icre)1Rsb/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Atg16l1 mutation (44 available)
Tg(Defa6-icre)1Rsb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased mortality and Paneth cell defects following exposure to 3% DSS in the drinking water following infection with mouse norovirus

• increased mortality following exposure to 5% DSS in the drinking water independent of infection with mouse norovirus

digestive/alimentary system

abnormal intestine physiology ( J:340266 )

• in culture intestinal organoids show impaired growth and increased susceptibility to TNF-induced death

increased susceptibility to induced colitis ( J:340266 )

• following 5% DSS treatment mice show increased shortening of the colon and increased colonic inflammation

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased mortality and Paneth cell defects following exposure to 3% DSS in the drinking water following infection with mouse norovirus

• increased mortality following exposure to 5% DSS in the drinking water independent of infection with mouse norovirus

immune system

increased susceptibility to induced colitis ( J:340266 )

• following 5% DSS treatment mice show increased shortening of the colon and increased colonic inflammation

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased mortality and Paneth cell defects following exposure to 3% DSS in the drinking water following infection with mouse norovirus

• increased mortality following exposure to 5% DSS in the drinking water independent of infection with mouse norovirus

Allelic Composition	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Itgax-cre)1-1Reiz/?
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Atg16l1 mutation (44 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:221019 )

N	• normal up-regulation of expression of autophagy regulators in intestinal epithelia, the mesenchymal compartment, and in cecal patches after infection with Salmonella typhimurium as seen in controls

immune system

immune system phenotype ( J:221019 )

N	• normal cytokine response by intestinal epithelial cells to infection

Allelic Composition	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/?
Genetic Background	involves: C57BL/6J * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal autophagy ( J:221019 )

• reduced expression of autophagy regulators in intestinal epithelia, the mesenchymal compartment, and in cecal patches after infection with Salmonella typhimurium

immune system

cecum inflammation ( J:221019 )

• increased inflammation after infection

increased macrophage cell number ( J:221019 )

• greater number of CD11c+ mononuclear cells found in mesenteric lymph nodes after infection

abnormal cytokine level ( J:221019 )

abnormal circulating interleukin level ( J:221019 )

increased circulating interleukin-1 beta level ( J:221019 )

• significantly increased levels in the terminal Ileum and the cecum

increased circulating interleukin-6 level ( J:221019 )

• significantly increased levels in the terminal Ileum and the cecum

abnormal chemokine level ( J:221019 )

• higher levels of CXCL1 and CCL2 in epithelial cells after infection

increased susceptibility to bacterial infection ( J:221019 )

• reduced up-regulation of antimicrobial proteins in intestinal epithelium of Salmonella typhimurium infected mice

• increased numbers of Salmonella in the spleen and mesenteric lymph nodes

digestive/alimentary system

abnormal Paneth cell morphology ( J:221019 )

• abnormal Paneth cell granules before and after infection

decreased Paneth cell number ( J:221019 )

• fewer Paneth cells/ crypt both before and after infection

cecum inflammation ( J:221019 )

• increased inflammation after infection

homeostasis/metabolism

abnormal autophagy ( J:221019 )

• reduced expression of autophagy regulators in intestinal epithelia, the mesenchymal compartment, and in cecal patches after infection with Salmonella typhimurium

abnormal cytokine level ( J:221019 )

abnormal circulating interleukin level ( J:221019 )

increased circulating interleukin-1 beta level ( J:221019 )

• significantly increased levels in the terminal Ileum and the cecum

increased circulating interleukin-6 level ( J:221019 )

• significantly increased levels in the terminal Ileum and the cecum

abnormal chemokine level ( J:221019 )

• higher levels of CXCL1 and CCL2 in epithelial cells after infection

hematopoietic system

increased macrophage cell number ( J:221019 )

• greater number of CD11c+ mononuclear cells found in mesenteric lymph nodes after infection

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:221019 )

• abnormal Paneth cell granules before and after infection

decreased Paneth cell number ( J:221019 )

• fewer Paneth cells/ crypt both before and after infection

Allelic Composition	Api5^em1Cad/Api5^em1Cad Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/0
Genetic Background	involves: C57BL/6J * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Api5^em1Cad mutation (0 available); any Api5 mutation (33 available)
Atg16l1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Atg16l1 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:340266 )

• fewer than expected are recovered

Allelic Composition	Api5^em1Cad/Api5⁺ Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Vil1-cre)997Gum/0
Genetic Background	involves: C57BL/6J * C57BL/6N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal Paneth cell morphology ( J:340266 )

• increased proportion of abnormal Paneth cells

decreased Paneth cell number ( J:340266 )

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:340266 )

• increased proportion of abnormal Paneth cells

decreased Paneth cell number ( J:340266 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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