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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Russell E Vance
MGI ID: MGI:6196853
Synonyms: iOvaFla
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce page
Germline Transmission:  Earliest citation of germline transmission: J:260047
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Mutation detailsA construct encoding a loxP-flanked transcriptional STOP cassette upstream of chicken ovalbumin lacking its signal sequence fused to the C-terminal 166 amino acids of Legionella pneumophila flagellin and an IRES-GFP downstream of the fusion gene was targeted to the locus. This creates a conditional-ready allele that will only be expressed after cre-mediated deletion of the STOP cassette. Expression of flagellin activates endogenous NAIP/NLLRC4 inflammasome while the ovalbumin permits the tracking of the adaptive immune response. (J:260047)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  830 strains or lines available
Original:  J:260047 Nichols RD, et al., NAIP/NLRC4 inflammasome activation in MRP8(+) cells is sufficient to cause systemic inflammatory disease. Nat Commun. 2017 Dec 20;8(1):2209
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory