Mouse Genome Informatics
cn1
    Pax6tm1Ued/Pax6tm1Ued
Tg(Six3-cre)69Frty/0

involves: 129P2/OlaHsd * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• thalamocortical axonal development is disrupted compared to in wild-type mice
• at E14.5, the cell-sparse zone spanning the diencephalic-telencephalic border appears disorganized and only a narrow cell-sparse shaft extended across the ventral telencephalon unlike in wild-type mice
• at E14.5, an abnormally thin bundle of thalamocortical axons cross the ventral telencephalon with much of the bundle of axons descending through the diencephalon appearing to end at the diencephalic-telencephalic border unlike in wild-type mice
• at E14.5, a small number of axons leave the internal capsule along it's length to grow in a ventral direction unlike in wild-type mice
• at E16.5, the internal capsule appears abnormally narrow and reduced in size compared to in wild-type mice
• at E16.5, diI injections label a bifurcated tract in which some axons course ventrally in the direction of the hypothalamus unlike in wild-type mice
• unlike in wild-type mice, many thalamic axons fail to navigate normal from the diencephalic-telencephalic border to the internal capsule and fail to exit in a ventral direction
• at E16.5, some descending corticofugal axons from the visual cortex become misrouted unlike in wild-type mice
• at E16.5, the internal capsule appears abnormally narrow and reduced in size compared to in wild-type mice


Mouse Genome Informatics
cn2
    Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Bmpr1btm1Kml/Bmpr1b+
Tg(Six3-cre)69Frty/0

involves: 129S/SvEv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• many dorsal retinal ganglion cell axons form ectopic termination zones
• eye size and retinal layer morphology are normal

nervous system
• many dorsal retinal ganglion cell axons form ectopic termination zones
• eye size and retinal layer morphology are normal


Mouse Genome Informatics
cn3
    Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Bmpr1btm1Kml/Bmpr1btm1Kml
Tg(Six3-cre)69Frty/0

involves: 129S/SvEv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• at E12.5 the margin of the pigment epithelium is rough and a ventral discontinuity of the pigment is seen

vision/eye
• beginning at E11.25-E11.50 excess apoptosis is seen throughout the retina
• around E11.5 a drastic reduction in cell proliferation is seen in the retina
• Atoh7 expression is not initiated at E11.5 suggesting a failure to initiate retinal neurogenesis
• beginning at E11.25-E11.50 the retinal neuroectoderm is thinner
• at E12.5 the margin of the pigment epithelium is rough and a ventral discontinuity of the pigment is seen
• eyes are small at E12.5 and absent at birth

cellular
• beginning at E11.25-E11.50 excess apoptosis is seen throughout the retina


Mouse Genome Informatics
cn4
    Pou4f2tm4Whk/Pou4f2tm4Whk
Tg(Six3-cre)69Frty/?

involves: 129S/SvEv * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• clearly abnormal in 16 day old mice
• thinner with smaller diameter fibers
• unmyelinated fibers
• deformed at E14.5
• overall structure remains normal through 5 months of age
• reduced cell proliferation and increased apoptosis
• more than 98% of retinal ganglion cells ablated at E14.5
• only displaced amacrine cells present at 16 days of age
• noticeably thinner at E14.5
• 30-50% thinner than controls at 16 days of age
• saturated amplitudes of both light and dark adapted b-waves 25% of normal
• dark adapted a-wave amplitude 42% of normal
• negative scotopic threshold response is very small
• positive scotopic threshold response is absent

nervous system
• clearly abnormal in 16 day old mice
• thinner with smaller diameter fibers
• unmyelinated fibers
• deformed at E14.5


Mouse Genome Informatics
cn5
    Eomestm1.1Whk/Eomestm1.1Whk
Tg(Six3-cre)69Frty/0

involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• at E18.5, there is dramatic increase in apoptotic retinal ganglion cells compared to heterozygous retinas
• apoptotic cells are more numerous at P1, P6, and P12 than in controls but differences are less than at E18
• more apoptotic cells are also detected in the ganglion cell layer, inner nuclear layer and outer nuclear layer but differences from controls are not significant after P12
• density of retinal ganglion cell (RGC) axon bundles is notably reduced
• orientation of RGC axons towards optic disk is abnormal
• 30% reduction in number of retinal ganglion cell RGC axons in peripheral and central regions of the retina compared to heterozygotes
• in adults, optic nerves are 30% smaller than heterozygous controls
• few axons are myelinated compared to control optic nerves; where present, myelin ensheathment is thinner, disorganized, and loosely packed
• some neurites show smaller diameters than normal axons and contain large numbers of microtubules instead of neurofilaments
• thickness is slightly reduced relative to controls

nervous system
• density of retinal ganglion cell (RGC) axon bundles is notably reduced
• orientation of RGC axons towards optic disk is abnormal
• 30% reduction in number of retinal ganglion cell RGC axons in peripheral and central regions of the retina compared to heterozygotes
• in adults, optic nerves are 30% smaller than heterozygous controls
• few axons are myelinated compared to control optic nerves; where present, myelin ensheathment is thinner, disorganized, and loosely packed
• some neurites show smaller diameters than normal axons and contain large numbers of microtubules instead of neurofilaments

cellular
• at E18.5, there is dramatic increase in apoptotic retinal ganglion cells compared to heterozygous retinas
• apoptotic cells are more numerous at P1, P6, and P12 than in controls but differences are less than at E18
• more apoptotic cells are also detected in the ganglion cell layer, inner nuclear layer and outer nuclear layer but differences from controls are not significant after P12


Mouse Genome Informatics
cn6
    Sox11tm1.1Gan/Sox11tm1.1Gan
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Six3-cre)69Frty/0

involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die before P14

vision/eye
• 6-fold increase starting at E14.5
• 10-fold increase starting at E16.5
• only a few cells present at E12.5
• impaired retinal ganglion cell development

growth/size

cellular
• 6-fold increase starting at E14.5
• 10-fold increase starting at E16.5

nervous system
• only a few cells present at E12.5


Mouse Genome Informatics
cn7
    Sox4tm1Vlf/Sox4tm1Vlf
Tg(Six3-cre)69Frty/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• mice exhibit normal numbers of horizontal, Muller glial, cone and rod cells (J:199663)
• 2-fold increase starting at E14.5
• impaired retinal ganglion cell development
• reduced number of axon bundles in the retina
• in the inner nuclear layer and ganglion cell layer
• beginning at E16.5
• moderate at P0 and in adult mice

cellular
• 2-fold increase starting at E14.5
• reduced in retinal axon bundles

nervous system
• reduced in retinal axon bundles
• in the inner nuclear layer and ganglion cell layer
• beginning at E16.5
• moderate at P0 and in adult mice


Mouse Genome Informatics
cn8
    Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Six3-cre)69Frty/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• some retinal regions are very thin; especially in the ganglion cell and inner nuclear layers or less commonly in the outer nuclear layer
• the peripheral retina is thinner at P6
• in some regions few or no blood vessels are observed on the vitreal face of the retina while in other regions clusters of blood vessels occupy the vitreal face
• overall density of astrocytes and endothelial cells in the vascularized territory of this retina is several fold higher than in controls
• many vessels in the developing retinal vascular plexus are not patent at P7 and P11 unlike in controls
• absence of the normal intraretinal capillary beds in the inner and outer plexiform layers
• absence of vessels in the overlying the peripheral retina at P6
• some regions are very thin
• some regions are very thin
• not as common as in the inner nuclear and ganglion cell layers
• regions of extensive detachment with numerous macrophages in the subretinal space, severe folding of the retina, accumulation of interstitial fluid, and/or development of interstitial fibrosis
• interstitial fibrosis is seen in some regions

cardiovascular system
• in some regions few or no blood vessels are observed on the vitreal face of the retina while in other regions clusters of blood vessels occupy the vitreal face
• overall density of astrocytes and endothelial cells in the vascularized territory of this retina is several fold higher than in controls
• many vessels in the developing retinal vascular plexus are not patent at P7 and P11 unlike in controls
• absence of the normal intraretinal capillary beds in the inner and outer plexiform layers
• absence of vessels in the overlying the peripheral retina at P6
• modest delay in the expansion of the astrocyte front in the developing retina at P3-P6 that is gone by P8
• endothelial cell growth is significantly retarded at all postnatal ages with the radial position of the growing endothelial cells largely arrested by P6
• filopodia-bearing endothelial cells are seen throughout much of the vascular plexus in the retina instead of being located predominantly in the growing front
• large excess of tip cells in the developing retinal vascular plexus

homeostasis/metabolism
• in the retina


Mouse Genome Informatics
cn9
    Isl1tm1.1Whk/Isl1tm1.1Whk
Tg(Six3-cre)69Frty/0

involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• the number and organization of the photoreceptor cells in the outer nuclear layer are normal (J:146349)
• at E17.5, the number of cells undergoing apoptosis in the retina is greater than in wild-type retinas
• however, retinal apoptosis at E14.5 is normal
• at P10, amacrine cells are reduced compared to in wild-type mice
• at P16, cholinergic amacrine cells are completely lost unlike in wild-type mice
• at P10, the number of bipolar cells is reduced compared to in wild-type mice
• at P16, cone on-bipolar and rod bipolar cells are completely lost unlike in wild-type mice
• at E17.5, the number of Pou4f2+ retinal ganglion cells in the neuroblast layer is greater than in wild-type mice
• however, mice exhibit normal retinal ganglion cell development and numbers at E14.5
• 28% Pou4f2+ retinal ganglion cells of wild-type at P5
• 5% Pou4f2+ retinal ganglion cells of wild-type at P16
• at P16, the optic nerve is thin and severely disrupted compared to in wild-type mice within thin axons that are not properly myelinated
• axons within the optic never exhibit degeneration unlike in wild-type mice
• at P16
• the inner nuclear layer is half as thick as in wild-type mice due to a decrease in cell numbers within the layer
• the margins of the outer plexiform layer are ragged unlike in wild-type mice

nervous system
• at P10, amacrine cells are reduced compared to in wild-type mice
• at P16, cholinergic amacrine cells are completely lost unlike in wild-type mice
• at P10, the number of bipolar cells is reduced compared to in wild-type mice
• at P16, cone on-bipolar and rod bipolar cells are completely lost unlike in wild-type mice
• at E17.5, the number of Pou4f2+ retinal ganglion cells in the neuroblast layer is greater than in wild-type mice
• however, mice exhibit normal retinal ganglion cell development and numbers at E14.5
• 28% Pou4f2+ retinal ganglion cells of wild-type at P5
• 5% Pou4f2+ retinal ganglion cells of wild-type at P16
• at P16, the optic nerve is thin and severely disrupted compared to in wild-type mice within thin axons that are not properly myelinated
• axons within the optic never exhibit degeneration unlike in wild-type mice

cellular
• at E17.5, the number of cells undergoing apoptosis in the retina is greater than in wild-type retinas
• however, retinal apoptosis at E14.5 is normal


Mouse Genome Informatics
cn10
    Resttm1.1Whk/Resttm1.1Whk
Tg(Six3-cre)69Frty/0

involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• increase in the number of mitotic retinal progenitor cells compared to littermate controls
• many cell clumps protrude towards the retinal pigment epithelia
• at E14, E15.5 and P20

nervous system
• at E14, E15.5 and P20


Mouse Genome Informatics
cn11
    Atoh7tm2Gan/Atoh7tm2Gan
Resttm1.1Whk/Resttm1.1Whk
Tg(Six3-cre)69Frty/0

involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• mis-patterning of the retina is more severe than in mutant mice wild-type for Atoh7
• few ganglion cells are detected in the nascent retinal ganglion layer at E13.5 despite many being generated in the neuroblast layer suggesting a defect in migration and maturation
• many dying cells are present in the retinal ganglion cell layer at E13.5


Mouse Genome Informatics
cn12
    Sox11tm1.1Gan/Sox11tm1.1Gan
Tg(Six3-cre)69Frty/0

involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• mice exhibit normal numbers of horizontal, Muller glial, cone and rod cells (J:199663)
• 2-fold increase starting at E14.5
• impaired retinal ganglion cell development
• reduced number of axon bundles in the retina
• in the inner nuclear layer and ganglion cell layer
• beginning from E12.5 to E16.5
• moderate at P0 and in adult mice

growth/size
• moderate
• however, mice exhibit normal body weight and size by P30

cellular
• 2-fold increase starting at E14.5
• reduced in retinal axon bundles

nervous system
• reduced in retinal axon bundles
• in the inner nuclear layer and ganglion cell layer
• beginning from E12.5 to E16.5
• moderate at P0 and in adult mice


Mouse Genome Informatics
cn13
    Isl1tm1Gan/Isl1tm2Gan
Tg(Six3-cre)69Frty/?

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
• mice have much thinner optic nerves, optic chiasms and optic tracts

nervous system
• mice have much thinner optic nerves, optic chiasms and optic tracts
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
• mice have much thinner optic nerves, optic chiasms and optic tracts


Mouse Genome Informatics
cn14
    Isl1tm2Gan/Isl1tm2Gan
Tg(Six3-cre)69Frty/?

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
• mice have much thinner optic nerves, optic chiasms and optic tracts

nervous system
• mice have much thinner optic nerves, optic chiasms and optic tracts
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
• mice have much thinner optic nerves, optic chiasms and optic tracts


Mouse Genome Informatics
cn15
    Isl1tm2Gan/Isl1tm2Gan
Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk
Tg(Six3-cre)69Frty/?

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present

nervous system
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present


Mouse Genome Informatics
cn16
    Isl1tm1Gan/Isl1tm2Gan
Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk
Tg(Six3-cre)69Frty/?

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present

nervous system
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present


Mouse Genome Informatics
cn17
    Chmtm1.1Seab/Chmtm1.1Seab
Tg(Six3-cre)69Frty/0

involves: 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• no depigmentation in the retinal pigment layer (J:105458)
• significantly shorter than normal (J:105458)
• 7-8 nuclei thick at 2 months of age (J:105458)
• 4-5 nuclei thick at 4 months of age (J:105458)
• single flash electroretinography shows the loss of "a" waves (J:105458)

nervous system
• significantly shorter than normal (J:105458)

Mouse Models of Human Disease
OMIM IDRef(s)
Choroideremia; CHM 303100 J:105458


Mouse Genome Informatics
cn18
    Chmtm1.1Seab/Y
Tg(Six3-cre)69Frty/0

involves: 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• no depigmentation in the retinal pigment layer (J:105458)
• significantly shorter than normal (J:105458)
• 7-8 nuclei thick at 2 months of age (J:105458)
• 4-5 nuclei thick at 4 months of age (J:105458)
• single flash electroretinography shows the loss of "a" waves (J:105458)

nervous system
• significantly shorter than normal (J:105458)

Mouse Models of Human Disease
OMIM IDRef(s)
Choroideremia; CHM 303100 J:105458


Mouse Genome Informatics
cn19
    Ntrk2tm2Lfr/Ntrk2tm2Lfr
Tg(Six3-cre)69Frty/?
Tg(Thy1-YFP)HJrs/?

involves: C57BL/6 * CBA * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in control mice
• at P28, mice have fewer ON and OFF RGCs than controls
• at P28, mice have fewer numbers of ON RGC dendritic branches
• at P50, 55.4+/-4.3% of RGCs are bilaminated compared to 37.8+/-1.1% in controls

nervous system
• at P28, mice have fewer numbers of ON retinal ganglion cells (RGCs) dendritic branches
• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in control mice
• at P28, mice have fewer ON and OFF RGCs than controls
• at P28, mice have fewer numbers of ON RGC dendritic branches
• at P50, 55.4+/-4.3% of RGCs are bilaminated compared to 37.8+/-1.1% in controls


Mouse Genome Informatics
cn20
    Hbegftm1Hhar/Hbegftm1Hhar
Tg(Six3-cre)69Frty/0

involves: C57BL/6 * CBA * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• Haloperidol, a dopamine receptor antagonist, ameliorates the hyperlocomotion both in dark and light phases
• Clozapine, a DA/serotonin receptor antagonist, reduces the locomotor activity only in light phase
• PPI deficits are significantly reversed by atypical antipsychotics, risperidone and clozapine but not by a typical neuroleptic haloperidol
• Clozapine, but not haloperidol, significantly attenuates the decreased social interaction behavior
• in a Y maze, mice display a significant decrease in alternation compared to control mice
• mice are more active than control mice over the 24-hr period (both dark and light phases)
• during the first 0-3 hr in a novel environment, KO mice are more active than control mice
• Haloperidol, a dopamine receptor antagonist, ameliorates the hyperlocomotion both in dark and light phases
• Clozapine, a DA/serotonin receptor antagonist, reduces the locomotor activity only in light phase
• the mean duration per contact as well as the time of the interaction are significantly less than in control mice
• Clozapine, but not haloperidol, significantly attenuates the decreased social interaction behavior

nervous system
• the number of spines per 10 mm of dendritic segment are lower in KO than in control mice
• diminished PPI at prepulse intensities at both 73 and 76 dB
• PPI deficits are significantly reversed by atypical antipsychotics, risperidone and clozapine but not by a typical neuroleptic haloperidol


Mouse Genome Informatics
cn21
    Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(Six3-cre)69Frty/0

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• no overt eye abnormalities are seen, the retinal layers and retinotectal projections are normal (J:96964)