Macf1^tm1Efu
Targeted Allele Detail

Summary

• Symbol: Macf1^tm1Efu
• Name: microtubule-actin crosslinking factor 1; targeted mutation 1, Elaine Fuchs
• MGI ID: MGI:3828998
• Synonyms: ACF7^fl, MACF1^f
• Gene: Macf1 Location: Chr4:123243426-123581331 bp, - strand Genetic Position: Chr4, 57.42 cM
• Alliance: Macf1^tm1Efu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143595
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette with a 5' loxP site was inserted upstream of exon 6 and an additional loxP site was inserted downstream of exon 8. (J:143595)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Macf1 Mutation: 853 strains or lines available

References

• Original: J:143595 Wu X, et al., ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell. 2008 Oct 3;135(1):137-48
• All: 11 reference(s)