Isl1^tm2Gan
Targeted Allele Detail

Summary

• Symbol: Isl1^tm2Gan
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 2, Lin Gan
• MGI ID: MGI:3797783
• Synonyms: Isl1^loxP
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm2Gan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134978
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A FRT-flanked neo-cassette and a loxP site was placed upstream of exon 2 and an additional loxP site was placed downstream of the exon. Germline mice were crossed with FLPe expressing mice to remove the neo-cassette, leaving exon 2 flanked by loxP sites. (J:134978)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 33 strains or lines available

References

• Original: J:134978 Pan L, et al., ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development. 2008 Jun;135(11):1981-90
• All: 11 reference(s)