Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1Gan mutation
(0 available);
any
Isl1 mutation
(33 available)
Isl1tm2Gan mutation
(0 available);
any
Isl1 mutation
(33 available)
Tg(Six3-cre)69Frty mutation
(2 available)
|
|
|
vision/eye
|
|
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
|
|
|
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
|
|
|
• mice have much thinner optic nerves, optic chiasms and optic tracts
|
nervous system
|
|
• mice have much thinner optic nerves, optic chiasms and optic tracts
|
|
|
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
|
|
|
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
|
|
|
• mice have much thinner optic nerves, optic chiasms and optic tracts
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm2Gan mutation
(0 available);
any
Isl1 mutation
(33 available)
Tg(Six3-cre)69Frty mutation
(2 available)
|
|
|
vision/eye
|
|
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
|
|
|
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
|
|
|
• mice have much thinner optic nerves, optic chiasms and optic tracts
|
nervous system
|
|
• mice have much thinner optic nerves, optic chiasms and optic tracts
|
|
|
• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
|
|
|
• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5
• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5
• adult mice only have about a third the number of retinal ganglion cells as do the controls
|
|
|
• mice have much thinner optic nerves, optic chiasms and optic tracts
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm2Gan mutation
(0 available);
any
Isl1 mutation
(33 available)
Pou4f2tm1(ALPP)Whk mutation
(0 available);
any
Pou4f2 mutation
(7 available)
Pou4f2tm2Whk mutation
(0 available);
any
Pou4f2 mutation
(7 available)
Tg(Six3-cre)69Frty mutation
(2 available)
|
|
|
vision/eye
|
|
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
|
|
|
• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present
|
nervous system
|
|
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
|
|
|
• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1Gan mutation
(0 available);
any
Isl1 mutation
(33 available)
Isl1tm2Gan mutation
(0 available);
any
Isl1 mutation
(33 available)
Pou4f2tm1(ALPP)Whk mutation
(0 available);
any
Pou4f2 mutation
(7 available)
Pou4f2tm2Whk mutation
(0 available);
any
Pou4f2 mutation
(7 available)
Tg(Six3-cre)69Frty mutation
(2 available)
|
|
|
vision/eye
|
|
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
|
|
|
• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present
|
nervous system
|
|
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
|
|
|
• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present
|
Analysis Tools