Pou4f2^tm4(DTA)Whk
Targeted Allele Detail

Summary

• Symbol: Pou4f2^tm4(DTA)Whk
• Name: POU domain, class 4, transcription factor 2; targeted mutation 4, William H Klein
• MGI ID: MGI:3838536
• Synonyms: brn3b^Z-dta, Pou4f2^lacZ-dta, Pou4f2^tm4Whk
• Gene: Pou4f2 Location: Chr8:79159639-79163274 bp, - strand Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
• Alliance: Pou4f2^tm4(DTA)Whk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97089
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence was replaced by a floxed lacZ with a stop codon, a diphtheria toxin A gene, and a neomycin selection cassette. As long as lacZ remains in place, the diphtheria toxin A gene is not expressed. (J:97089)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou4f2 Mutation: 7 strains or lines available

References

• Original: J:97089 Mu X, et al., Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina. Curr Biol. 2005 Mar 29;15(6):525-30
• All: 11 reference(s)