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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ifngtm1Ts
targeted mutation 1, Timothy Stewart
MGI:1857184
Summary 32 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ifngtm1Ts/Ifngtm1Ts B6.129S7-Ifngtm1Ts MGI:4365971
hm2
Ifngtm1Ts/Ifngtm1Ts B6.129S7-Ifngtm1Ts/J MGI:3696100
hm3
Ifngtm1Ts/Ifngtm1Ts C.129S7(B6)-Ifngtm1Ts/J MGI:4839056
hm4
Ifngtm1Ts/Ifngtm1Ts C.129S7-Ifngtm1Ts MGI:4838443
hm5
Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd MGI:3693883
hm6
Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss MGI:4843967
hm7
Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd * BALB/c MGI:4838445
hm8
Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd * C57BL/6 MGI:3587743
hm9
Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd * C57BL/6J MGI:4838441
hm10
Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp MGI:4839050
hm11
Ifngtm1Ts/Ifngtm1Ts involves: 129S7/SvEvBrd * NOD MGI:4838444
hm12
Ifngtm1Ts/Ifngtm1Ts NOD.129S7(B6)-Ifngtm1Ts/DvsJ MGI:3623449
hm13
Ifngtm1Ts/Ifngtm1Ts NOD.129S7(B6)-Ifngtm1Ts Prkdcscid MGI:3623448
hm14
Ifngtm1Ts/Ifngtm1Ts NOD.129S7-Ifngtm1Ts MGI:3622412
cn15
Ifngtm1Ts/Ifngtm1Ts
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL MGI:5514242
cn16
Foxo1tm1Flv/Foxo1tm1Flv
Ifngtm1Ts/Ifngtm1Ts
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ MGI:5448156
cx17
Apoetm1Unc/Apoetm1Unc
Ifngtm1Ts/Ifngtm1Ts
B6.129-Apoetm1Unc Ifngtm1Ts MGI:4938323
cx18
Ifngtm1Ts/Ifngtm1Ts
Ldlrtm1Her/Ldlrtm1Her
B6.129S7-Ldlrtm1Her Ifngtm1Ts MGI:4867042
cx19
Csf2tm1Mlg/Csf2tm1Mlg
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli
B6.129S-Csf2tm1Mlg Il3tm1Glli Ifngtm1TsIfngtm1Ts MGI:5431918
cx20
Ifngtm1Ts/Ifngtm1Ts
Tgfb1tm1Doe/Tgfb1tm1Doe
C.129-Ifngtm1Ts Tgfb1tm1Doe MGI:3721950
cx21
Ifngtm1Ts/Ifngtm1Ts
Prf1tm1Sdz/Prf1tm1Sdz
C.Cg-Prf1tm1Sdz Ifngtm1Ts MGI:4867045
cx22
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:4843969
cx23
Ifngtm1Ts/Ifng+
Socs1tm1Wehi/Socs1tm1Wehi
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:4850158
cx24
Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Wehi/Socs1tm1Wehi
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:4430638
cx25
Csf2tm1Dran/Csf2tm1Dran
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:3586344
cx26
Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Jni/Socs1tm1Jni
involves: 129S7/SvEvBrd MGI:3783715
cx27
Ifngtm1Ts/Ifngtm1Ts
Nlrp1aNeut1/Nlrp1aNeut1
involves: 129S7/SvEvBrd * C57BL/6 MGI:5474288
cx28
Ifngtm1Ts/Ifngtm1Ts
Tg(SFTPC-Il18)AThos/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2 MGI:5688500
cx29
Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts
involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp MGI:4839049
cx30
Ifngtm1Ts/Ifngtm1Ts
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J MGI:3629594
cx31
Faslpr/Faslpr
Ifngtm1Ts/Ifng+
MRL.Cg-Ifngtm1Ts Faslpr MGI:3801419
cx32
Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts
MRL.Cg-Ifngtm1Ts Faslpr MGI:3801418


Genotype
MGI:4365971
hm1
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
B6.129S7-Ifngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• sudden death occurs 5 to 7 weeks after infection with Leishmania major (J:18801)
• sudden death occurs 5 to 7 weeks after infection with Leishmania major (J:18801)
• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls (J:110826)
• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls (J:110826)
• higher mortality is seen following infection with JHMV compared to wild-type controls (J:112048)
• higher mortality is seen following infection with JHMV compared to wild-type controls (J:112048)
• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background (J:77491)
• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background (J:77491)

tumorigenesis
• Background Sensitivity: 50% of mice on a congenic C57BL/5 background develop disseminated lymphomas compared to 0% of mice on a congenic BALB/c background (J:77491)
• most lymphomas are diffuse large cell lymphomas (J:77491)
• Background Sensitivity: 50% of mice on a congenic C57BL/5 background develop disseminated lymphomas compared to 0% of mice on a congenic BALB/c background (J:77491)
• most lymphomas are diffuse large cell lymphomas (J:77491)
• in a few mice (J:77491)
• in a few mice (J:77491)
• in a few mice (J:77491)
• in a few mice (J:77491)
• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background (J:77491)
• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background (J:77491)

immune system
• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection (J:112048)
• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection (J:112048)
• immature B cells fail to be excluded from the lymph nodes (J:112084)
• immature B cells fail to be excluded from the lymph nodes (J:112084)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls (J:112048)
• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls (J:112048)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• significant increase in the numbers of immature B cells in the lymph nodes (J:112084)
• significant increase in the numbers of immature B cells in the lymph nodes (J:112084)
• after infection with Leishmania major the number of lymphocytes producing IL4 increases unlike in control mice where the number of lymphocytes producing IFNG increases (J:18801)
• after infection with Leishmania major the number of lymphocytes producing IL4 increases unlike in control mice where the number of lymphocytes producing IFNG increases (J:18801)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL10 in response to JHMV antigen compared to cells from similarly infected wild-type mice (J:112048)
• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL10 in response to JHMV antigen compared to cells from similarly infected wild-type mice (J:112048)
• cervical lymph node cells from JHMV infected mice secrete more IL2 in response to JHMV antigen compared to cells from similarly infected wild-type mice (J:112048)
• cervical lymph node cells from JHMV infected mice secrete more IL2 in response to JHMV antigen compared to cells from similarly infected wild-type mice (J:112048)
• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL5 in response to JHMV antigen compared to cells from similarly infected wild-type mice (J:112048)
• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL5 in response to JHMV antigen compared to cells from similarly infected wild-type mice (J:112048)
• after infection with Leishmania major mice display minimal Th1 type responses and increased Th2 type responses (J:18801)
• after infection with Leishmania major levels of IgG1 and IgE are increased while levels of IgG2a and IgG3 remain low (J:18801)
• after infection with Leishmania major mice display minimal Th1 type responses and increased Th2 type responses (J:18801)
• after infection with Leishmania major levels of IgG1 and IgE are increased while levels of IgG2a and IgG3 remain low (J:18801)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• develop progressive infection characterized by large lesions at the site of inoculation and sudden death 5 to 7 weeks after infection with Leishmania major (J:18801)
• numbers of parasites present in the footpads are substantially increased compared to wild-type and heterozygous controls (J:18801)
• develop progressive infection characterized by large lesions at the site of inoculation and sudden death 5 to 7 weeks after infection with Leishmania major (J:18801)
• numbers of parasites present in the footpads are substantially increased compared to wild-type and heterozygous controls (J:18801)
• sudden death occurs 5 to 7 weeks after infection with Leishmania major (J:18801)
• sudden death occurs 5 to 7 weeks after infection with Leishmania major (J:18801)
• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls (J:110826)
• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls (J:110826)
• following infection with the JHM strain of mouse hepatitis virus (JHMV) mice display a slower clinical recovery and higher viral titers in the central nervous system compared to wild-type controls (J:112048)
• however, no differences are found in JHMV specific cytotoxic T lymphocyte activity (J:112048)
• at 14 days post infection with JHMV a 10 fold increase in the number of viral antigen positive cells is detected in the brain with most of the infected cells being oligodendrocytes (J:112048)
• following infection with the JHM strain of mouse hepatitis virus (JHMV) mice display a slower clinical recovery and higher viral titers in the central nervous system compared to wild-type controls (J:112048)
• however, no differences are found in JHMV specific cytotoxic T lymphocyte activity (J:112048)
• at 14 days post infection with JHMV a 10 fold increase in the number of viral antigen positive cells is detected in the brain with most of the infected cells being oligodendrocytes (J:112048)
• higher mortality is seen following infection with JHMV compared to wild-type controls (J:112048)
• higher mortality is seen following infection with JHMV compared to wild-type controls (J:112048)
• after immunosuppressive treatment (anti-CD4 and anti-CD8 mAbs) allografts (BALB/c, H2-Ab1bm12 continue to display myocardial rejection at week 12 but do not display graft arterial disease, in contrast wild-type mice at week 12 display low levels of rejection but develop coronary arteriopathy (J:42090)
• after immunosuppressive treatment (anti-CD4 and anti-CD8 mAbs) allografts (BALB/c, H2-Ab1bm12 continue to display myocardial rejection at week 12 but do not display graft arterial disease, in contrast wild-type mice at week 12 display low levels of rejection but develop coronary arteriopathy (J:42090)

hematopoietic system
• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection (J:112048)
• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection (J:112048)
• immature B cells fail to be excluded from the lymph nodes (J:112084)
• immature B cells fail to be excluded from the lymph nodes (J:112084)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls (J:112048)
• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls (J:112048)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)
• after infection with Leishmania major (J:18801)




Genotype
MGI:3696100
hm2
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
B6.129S7-Ifngtm1Ts/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls (J:91927)
• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls (J:91927)
• die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis (J:47459)
• die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis (J:47459)
• most mice die by 9 days after infection with 1x106 Cryptosporidium parvum oocysts (J:50832)
• most mice die by 9 days after infection with 1x106 Cryptosporidium parvum oocysts (J:50832)

immune system
N
• do not exhibit defects on either IgE isotype switch or IgE production (J:114783)
• do not exhibit defects on either IgE isotype switch or IgE production (J:114783)
• 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice (J:136628)
• 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice (J:136628)
• 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice (J:120556)
• 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice (J:120556)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• in the blood, bone marrow and spleen following infection with BCG (J:47459)
• in the blood, bone marrow and spleen following infection with BCG (J:47459)
• unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers (J:122801)
• unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers (J:122801)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue (J:47459)
• develop splenomegaly after infection with BCG (J:47459)
• develop splenomegaly after infection with BCG (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes (J:47459)
• spleens become paler as BCG infection proceeds (J:47459)
• spleens become paler as BCG infection proceeds (J:47459)
• increase in circulating levels of CSF3 after infection with BCG especially in moribund mice (J:47459)
• increase in circulating levels of CSF3 after infection with BCG especially in moribund mice (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• in C. parvum infected mice (J:50832)
• in C. parvum infected mice (J:50832)
• increase in IL12 and decrease in IL10 secretion following LPS stimulation (J:134949)
• increase in IL12 and decrease in IL10 secretion following LPS stimulation (J:134949)
• enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro (J:134949)
• enhancement in LPS induced dendritic cell migration to the spleen (J:134949)
• enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro (J:134949)
• enhancement in LPS induced dendritic cell migration to the spleen (J:134949)
• enhancement in hapten induced Langerhan cell migration to the draining lymph nodes (J:134949)
• enhancement in hapten induced Langerhan cell migration to the draining lymph nodes (J:134949)
• dendritic cells show a greater ability to stimulate T cell proliferation in vitro (J:134949)
• dendritic cells show a greater ability to stimulate T cell proliferation in vitro (J:134949)
• in OVA fed mice only a modest decrease in the delayed type hypersensitivity response to injected OVA is seen in contrast this reaction is strongly decreased in similarly treated wild-type controls (J:45665)
• in OVA fed mice only a modest decrease in the delayed type hypersensitivity response to injected OVA is seen in contrast this reaction is strongly decreased in similarly treated wild-type controls (J:45665)
• display a more severe delayed type hypersensitivity reaction in response to sheep IgG (J:118730)
• display a more severe delayed type hypersensitivity reaction in response to sheep IgG (J:118730)
• the magnitude of the OVA specific antibody response to subcutaneous OVA challenge is reduced (J:45665)
• however, following oral OVA exposure OVA antibody levels in response to subcutaneous OVA challenge are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels (J:45665)
• the magnitude of the OVA specific antibody response to subcutaneous OVA challenge is reduced (J:45665)
• however, following oral OVA exposure OVA antibody levels in response to subcutaneous OVA challenge are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels (J:45665)
• IgG responses are restricted to IgG1 and IgG2b (J:45665)
• IgG responses are restricted to IgG1 and IgG2b (J:45665)
• splenocytes fail to produce IFN-gamma in response to H. pylori antigen stimulation (J:120556)
• splenocytes fail to produce IFN-gamma in response to H. pylori antigen stimulation (J:120556)
• splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen (J:120556)
• splenocytes from Helicobacter pylori infected mice produce 4-fold less IL-10 when cultured in the presence of H. pylori antigen (J:120556)
• by bone marrow dendritic cells following LPS stimulation (J:134949)
• by bone marrow dendritic cells following LPS stimulation (J:134949)
• by bone marrow dendritic cells following LPS stimulation (J:134949)
• by bone marrow dendritic cells following LPS stimulation (J:134949)
• splenocytes from Helicobacter pylori infected mice produce significantly more IL-4 than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen (J:120556)
• splenocytes from Helicobacter pylori infected mice produce significantly more IL-4 than splenocytes from wild-type controls when cultured in the presence of H. pylori antigen (J:120556)
• oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent subcutaneous exposure to the same antigen (J:45665)
• oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent subcutaneous exposure to the same antigen (J:45665)
• increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes (J:118730)
• increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes (J:118730)
• following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter (J:47459)
• following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen (J:47459)
• following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter (J:47459)
• following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen (J:47459)
• die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis (J:47459)
• die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis (J:47459)
• Background Sensitivity: mice on a C57BL/6 background lose weight and develop soft gelatinous stools over the course of a C. parvum infection while mice on a BALB/c background do not (J:50832)
• Background Sensitivity: in C. parvum infected mice on a C57BL/6 background, but not on a BALB/c background, the gastrointestinal tract is heavily colonized with parasites, the small intestines are distended and filled with gelatinous fluid, mesenteric lymph nodes are enlarged and in about 50% of mice gallbladders are enlarged (J:50832)
• Background Sensitivity: mice on a C57BL/6 background lose weight and develop soft gelatinous stools over the course of a C. parvum infection while mice on a BALB/c background do not (J:50832)
• Background Sensitivity: in C. parvum infected mice on a C57BL/6 background, but not on a BALB/c background, the gastrointestinal tract is heavily colonized with parasites, the small intestines are distended and filled with gelatinous fluid, mesenteric lymph nodes are enlarged and in about 50% of mice gallbladders are enlarged (J:50832)
• most mice die by 9 days after infection with 1x106 Cryptosporidium parvum oocysts (J:50832)
• most mice die by 9 days after infection with 1x106 Cryptosporidium parvum oocysts (J:50832)
• decrease in survival times of heart transplants from CBA mice after a 30 day course of anti-CD4 and anti-CD8 mAb (J:44346)
• only 10% of heart grafts survive more than 100 days compared to 36% of grafts in wild-type mice (J:44346)
• decrease in survival times of heart transplants from CBA mice after a 30 day course of anti-CD4 and anti-CD8 mAb (J:44346)
• only 10% of heart grafts survive more than 100 days compared to 36% of grafts in wild-type mice (J:44346)

behavior/neurological
• Background Sensitivity: increase in the number of defecations following a sound stimulus suggesting an enhancement of fear related responses in mice on a C57BL/6 background but not in mice on a BALB/c background (J:54250)
• prolonged freeze time and longer time to return to normal open field activity patterns following a startle stimulus relative to wild-type controls (J:54250)
• make fewer entries and spend less time in the open arms of an elevated maze relative to wild-type controls (J:54250)
• Background Sensitivity: increase in the number of defecations following a sound stimulus suggesting an enhancement of fear related responses in mice on a C57BL/6 background but not in mice on a BALB/c background (J:54250)
• prolonged freeze time and longer time to return to normal open field activity patterns following a startle stimulus relative to wild-type controls (J:54250)
• make fewer entries and spend less time in the open arms of an elevated maze relative to wild-type controls (J:54250)
• Background Sensitivity: increase in the number of defecations in a novel environment compared to wild-type controls in mice on a C57BL/6 background but not in mice on a BALB/c background (J:54250)
• the number of rearings is decreased in a novel environment (J:54250)
• initial locomotor activity is decreased; however, overall distance traveled is not different from controls (J:54250)
• Background Sensitivity: increase in the number of defecations in a novel environment compared to wild-type controls in mice on a C57BL/6 background but not in mice on a BALB/c background (J:54250)
• the number of rearings is decreased in a novel environment (J:54250)
• initial locomotor activity is decreased; however, overall distance traveled is not different from controls (J:54250)
• in a novel environment (J:54250)
• in a novel environment (J:54250)

cellular
• enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro (J:134949)
• enhancement in LPS induced dendritic cell migration to the spleen (J:134949)
• enhancement in the ability of dendritic cells to transmigrate across a membrane in response to RANTES in vitro (J:134949)
• enhancement in LPS induced dendritic cell migration to the spleen (J:134949)
• 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice (J:136628)
• 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice (J:136628)
• unlike in wild-type mice, treatment with LPS and DGalN or TNF-alpha and interferon-gamma fails to increase the production of reactive oxygen species in hepatocytes (J:122801)
• unlike in wild-type mice, treatment with LPS and DGalN or TNF-alpha and interferon-gamma fails to increase the production of reactive oxygen species in hepatocytes (J:122801)

renal/urinary system
• 1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls (J:118730)
• 1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls (J:118730)
• increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis (J:118730)
• increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis (J:118730)
• increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes (J:118730)
• increased susceptibility to induced accelerated antiglomerular basement membrane nephritis as determined by increased albuminuria and more severe pathological changes (J:118730)

homeostasis/metabolism
• increase in circulating levels of CSF3 after infection with BCG especially in moribund mice (J:47459)
• increase in circulating levels of CSF3 after infection with BCG especially in moribund mice (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• unlike in wild-type mice, treatment with LPS and DGalN fails to increase nitric oxide levels (J:122801)
• unlike in wild-type mice, treatment with LPS and DGalN fails to increase nitric oxide levels (J:122801)
• 1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls (J:118730)
• 1 day after induction of accelerated antiglomerular basement membrane nephritis no increase in total urinary nitrate or nitrate levels is detected unlike in similarly treated wild-type controls (J:118730)
• increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis (J:118730)
• increase in albuminuria on days 2, 3,and 4 following induction of accelerated antiglomerular basement membrane nephritis (J:118730)
• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls (J:91927)
• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls (J:91927)
• decrease in the number and area of regenerating muscle fibers 5 and 10 days after muscle injury (J:136628)
• fibrotic lesions are sometimes seen after injury (J:136628)
• 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice (J:136628)
• decrease in the number and area of regenerating muscle fibers 5 and 10 days after muscle injury (J:136628)
• fibrotic lesions are sometimes seen after injury (J:136628)
• 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice (J:136628)
• following a 48 h exposure to hyperoxia (98-99% oxygen) neutrophil migration into the lung air space and the increase in pulmonary alveolar permeability are decreased indicating a decrease susceptibility to the early phase of hyperoxia induced lung injury (J:108148)
• however, after 84 h of exposure to hyperoxia these measures are not different from similarly exposed to wild-type controls (J:108148)
• following a 48 h exposure to hyperoxia (98-99% oxygen) neutrophil migration into the lung air space and the increase in pulmonary alveolar permeability are decreased indicating a decrease susceptibility to the early phase of hyperoxia induced lung injury (J:108148)
• however, after 84 h of exposure to hyperoxia these measures are not different from similarly exposed to wild-type controls (J:108148)

muscle
• fibrotic lesions are sometimes seen after injury (J:136628)
• fibrotic lesions are sometimes seen after injury (J:136628)
• decrease in the number and area of regenerating fibers 5 and 10 days after injury (J:136628)
• fibrotic lesions are sometimes seen after injury (J:136628)
• however, prior to injury no difference in muscle fiber morphology are detected (J:136628)
• decrease in the number and area of regenerating fibers 5 and 10 days after injury (J:136628)
• fibrotic lesions are sometimes seen after injury (J:136628)
• however, prior to injury no difference in muscle fiber morphology are detected (J:136628)

digestive/alimentary system
• 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice (J:120556)
• 5 weeks after Helicobacter pylori infection, mice have a significantly decreased gastritis inflammation score compared to infected wild-type mice (J:120556)

hematopoietic system
• 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice (J:136628)
• 5 days after muscle injury fewer macrophages are present at the injury site compared to similarly treated wild-type mice (J:136628)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• in the blood, bone marrow and spleen following infection with BCG (J:47459)
• in the blood, bone marrow and spleen following infection with BCG (J:47459)
• unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers (J:122801)
• unlike in wild-type mice, treatment with LPS and DGalN fails to decrease NK T cell numbers (J:122801)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue (J:47459)
• develop splenomegaly after infection with BCG (J:47459)
• develop splenomegaly after infection with BCG (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes (J:47459)
• spleens become paler as BCG infection proceeds (J:47459)
• spleens become paler as BCG infection proceeds (J:47459)
• IgG responses are restricted to IgG1 and IgG2b (J:45665)
• IgG responses are restricted to IgG1 and IgG2b (J:45665)




Genotype
MGI:4839056
hm3
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
C.129S7(B6)-Ifngtm1Ts/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis (J:47459)
• die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis (J:47459)

immune system
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• in the blood, bone marrow and spleen following infection with BCG (J:47459)
• in the blood, bone marrow and spleen following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue (J:47459)
• develop splenomegaly after infection with BCG (J:47459)
• develop splenomegaly after infection with BCG (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes (J:47459)
• spleens become paler as BCG infection proceeds (J:47459)
• spleens become paler as BCG infection proceeds (J:47459)
• increase in circulating levels of CSF3 after infection with BCG especially in moribund mice (J:47459)
• increase in circulating levels of CSF3 after infection with BCG especially in moribund mice (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• decrease in the cytotoxicity of NK cells from mice primed with rIL12 (J:115144)
• decrease in the cytotoxicity of NK cells from mice primed with rIL12 (J:115144)
• decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation (J:56503)
• uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati (J:56503)
• decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation (J:56503)
• uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati (J:56503)
• C26 cells induce slightly reduced CTL activity compared to the response in similarly treat wild-type mice (J:115144)
• C26 cells induce slightly reduced CTL activity compared to the response in similarly treat wild-type mice (J:115144)
• exposure to rIL12 fails to prime macrophages against subsequent LPS exposure (J:115144)
• exposure to rIL12 fails to prime macrophages against subsequent LPS exposure (J:115144)
• lymphocytes form C25/Il12 cell primed mice produce about 3 fold higher levels of CSF2 (J:115144)
• lymphocytes form C25/Il12 cell primed mice produce about 3 fold higher levels of CSF2 (J:115144)
• in C26/Il12 tumors CD4+ T cells are more numerous relative to CD8+ T cells, in tumors in wild-type mice CD8+ T cells are more numerous (J:115144)
• in C26/Il12 tumors CD4+ T cells are more numerous relative to CD8+ T cells, in tumors in wild-type mice CD8+ T cells are more numerous (J:115144)
• following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter (J:47459)
• following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen (J:47459)
• following infection with BCG mice display an increased bacterial load throughout the infect in contrast to wild-type mice where bacterial numbers peak at 17 days post infection and decline thereafter (J:47459)
• following infection with BCG mice develop numerous granulomatous lesions in the liver and necrosis of both the liver and spleen (J:47459)
• die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis (J:47459)
• die by 6 - 10 weeks after infection with the avirulent BCG strain of Mycobacterium bovis (J:47459)
• Background Sensitivity: unlike mice on a C57BL/6 background, mice on a BALB/c background do not lose weight, show any change in stool consistency, or display heavy parasitic loads in the gastrointestinal tract over the course of a C. parvum infection (J:50832)
• Background Sensitivity: unlike mice on a C57BL/6 background, mice on a BALB/c background do not lose weight, show any change in stool consistency, or display heavy parasitic loads in the gastrointestinal tract over the course of a C. parvum infection (J:50832)

behavior/neurological
• prolonged freeze time following a startle stimulus relative to wild-type controls (J:54250)
• Background Sensitivity: no increase in the number of defecations following a sound stimulus is seen in mice on a BALB/c background unlike mice on a C57BL/6 background (J:54250)
• prolonged freeze time following a startle stimulus relative to wild-type controls (J:54250)
• Background Sensitivity: no increase in the number of defecations following a sound stimulus is seen in mice on a BALB/c background unlike mice on a C57BL/6 background (J:54250)
• the number of rearings is decreased in a novel environment (J:54250)
• Background Sensitivity: unlike mice on a C57BL/6 background, no increase in the number of defecations in a novel environment or following a sound stimulus is seen in mice on a BALB/c background, compared to wild-type controls (J:54250)
• the number of rearings is decreased in a novel environment (J:54250)
• Background Sensitivity: unlike mice on a C57BL/6 background, no increase in the number of defecations in a novel environment or following a sound stimulus is seen in mice on a BALB/c background, compared to wild-type controls (J:54250)
• in a novel environment (J:54250)
• in a novel environment (J:54250)

tumorigenesis
• when injected with 5 x 105 C26/Il12 cells only a few mice are able to reject the tumor, in contrast 80 - 100% of wild-type mice reject the tumor (J:115144)
• in C26/Il12 derived tumors, tumor vessels are more numerous and thinner compared to vessels in tumors in wild-type mice (J:115144)
• when injected with 5 x 105 C26/Il12 cells only a few mice are able to reject the tumor, in contrast 80 - 100% of wild-type mice reject the tumor (J:115144)
• in C26/Il12 derived tumors, tumor vessels are more numerous and thinner compared to vessels in tumors in wild-type mice (J:115144)
• tumor onset is accelerated in 40% of mice injected with 5 x 104 C26 carcinoma cells transduced with Il12 genes (C26/Il12) compared to similarly treated wild-type mice (J:115144)
• however, no difference is detected when parental C26 cells are used (J:115144)
• tumor onset is accelerated in 40% of mice injected with 5 x 104 C26 carcinoma cells transduced with Il12 genes (C26/Il12) compared to similarly treated wild-type mice (J:115144)
• however, no difference is detected when parental C26 cells are used (J:115144)

reproductive system
• after gestational day 10 the intercellular composition of the decidua changes suggesting accumulations of fluid and extracellular matrix, areas of necrosis are present and a lack of decidual cellularity is apparent (J:56503)
• after gestational day 10 the intercellular composition of the decidua changes suggesting accumulations of fluid and extracellular matrix, areas of necrosis are present and a lack of decidual cellularity is apparent (J:56503)
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)
• decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation (J:56503)
• uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati (J:56503)
• decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation (J:56503)
• uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati (J:56503)
• decrease in litter size and increase in the number of resorbed embryos in the first litter (J:56503)
• no difference in litter size or number of resorbed embryos is detected in subsequent pregnancies (J:56503)
• phenotype is independent of the genotype of the embryos (J:56503)
• decrease in litter size and increase in the number of resorbed embryos in the first litter (J:56503)
• no difference in litter size or number of resorbed embryos is detected in subsequent pregnancies (J:56503)
• phenotype is independent of the genotype of the embryos (J:56503)

homeostasis/metabolism
• increase in circulating levels of CSF3 after infection with BCG especially in moribund mice (J:47459)
• increase in circulating levels of CSF3 after infection with BCG especially in moribund mice (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)

embryogenesis
• after gestational day 10 the intercellular composition of the decidua changes suggesting accumulations of fluid and extracellular matrix, areas of necrosis are present and a lack of decidual cellularity is apparent (J:56503)
• after gestational day 10 the intercellular composition of the decidua changes suggesting accumulations of fluid and extracellular matrix, areas of necrosis are present and a lack of decidual cellularity is apparent (J:56503)
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)

hematopoietic system
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• in the blood, bone marrow and spleen following infection with BCG (J:47459)
• in the blood, bone marrow and spleen following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the red pulp is replaced with extramedullary hematopoietic tissue (J:47459)
• develop splenomegaly after infection with BCG (J:47459)
• develop splenomegaly after infection with BCG (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes (J:47459)
• following infection with BCG, the normal follicular structure of the red and white pulp is lost and the lymphocytic populations of the white pulp are replaced with sheets of leukocytes (J:47459)
• spleens become paler as BCG infection proceeds (J:47459)
• spleens become paler as BCG infection proceeds (J:47459)
• decrease in the cytotoxicity of NK cells from mice primed with rIL12 (J:115144)
• decrease in the cytotoxicity of NK cells from mice primed with rIL12 (J:115144)
• decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation (J:56503)
• uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati (J:56503)
• decrease in the number of apoptotic uNK cells in the metrial gland afte day 10 of gestation (J:56503)
• uNK cells at implantation sites fail to become heavily granulated and have poorly developed golgi apparati (J:56503)
• C26 cells induce slightly reduced CTL activity compared to the response in similarly treat wild-type mice (J:115144)
• C26 cells induce slightly reduced CTL activity compared to the response in similarly treat wild-type mice (J:115144)
• exposure to rIL12 fails to prime macrophages against subsequent LPS exposure (J:115144)
• exposure to rIL12 fails to prime macrophages against subsequent LPS exposure (J:115144)

endocrine/exocrine glands
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• the golgi apparatus is poorly developed, the rough ER is disorganized, and numerous mitochondria are seen in uNK cell at implantation sites at gestational day 12 (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)
• after day 10 of gestation increased numbers of uNK cells are found in the metrial gland compared to wild-type controls (J:56503)




Genotype
MGI:4838443
hm4
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
C.129S7-Ifngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the LD50 for Listeria monocytogenes infection is 10 CFU compared to greater than 104 CFU for wild-type and heterozygous controls (J:83180)
• however the LD50 for a mutant strain of L. monocytogenes (DP-L1942) is similar in homozygous mice and controls (J:83180)
• following vaccination mice are able to develop resistance to L. monocytogenes infection (J:83180)
• the LD50 for Listeria monocytogenes infection is 10 CFU compared to greater than 104 CFU for wild-type and heterozygous controls (J:83180)
• however the LD50 for a mutant strain of L. monocytogenes (DP-L1942) is similar in homozygous mice and controls (J:83180)
• following vaccination mice are able to develop resistance to L. monocytogenes infection (J:83180)
• die within 9 days of inoculation with T. gondii (strain ME49) unlike controls which survive more than 30 days (J:110826)
• highly susceptible to the normally avirulent T. gondii isolate, ts4 (J:110826)
• die within 9 days of inoculation with T. gondii (strain ME49) unlike controls which survive more than 30 days (J:110826)
• highly susceptible to the normally avirulent T. gondii isolate, ts4 (J:110826)

immune system
• the magnitude of the OVA specific antibody is reduced (J:45665)
• following oral OVA exposure OVA antibody levels are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels (J:45665)
• the magnitude of the OVA specific antibody is reduced (J:45665)
• following oral OVA exposure OVA antibody levels are essentially unchanged unlike in wild-type controls where oral exposure reduces antibody levels (J:45665)
• IgG responses are restricted to IgG1 and IgG2b (J:45665)
• IgG responses are restricted to IgG1 and IgG2b (J:45665)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• following infection with T. gondii (irradiate RH strain) splenocytes produce more IL-5 compared to similar cultures from wild-type mice (J:110826)
• following infection with T. gondii (irradiate RH strain) splenocytes produce more IL-5 compared to similar cultures from wild-type mice (J:110826)
• oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent exposure to the same antigen (J:45665)
• oral exposure to antigen (OVA) fails to reduce the responsiveness of mice to subsequent exposure to the same antigen (J:45665)
• incidence rate (17 of 24 compared to 1 of 16 in controls) and severity are increased compared to contols immunization results in about a 30% mortality rate (J:34161)
• immunized mice display meningeal and perivascular inflammatory infiltrates in the spinal cord and brain similar to those seen in susceptible strains like SJL/J (J:34161)
• incidence rate (17 of 24 compared to 1 of 16 in controls) and severity are increased compared to contols immunization results in about a 30% mortality rate (J:34161)
• immunized mice display meningeal and perivascular inflammatory infiltrates in the spinal cord and brain similar to those seen in susceptible strains like SJL/J (J:34161)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)
• the LD50 for Listeria monocytogenes infection is 10 CFU compared to greater than 104 CFU for wild-type and heterozygous controls (J:83180)
• however the LD50 for a mutant strain of L. monocytogenes (DP-L1942) is similar in homozygous mice and controls (J:83180)
• following vaccination mice are able to develop resistance to L. monocytogenes infection (J:83180)
• the LD50 for Listeria monocytogenes infection is 10 CFU compared to greater than 104 CFU for wild-type and heterozygous controls (J:83180)
• however the LD50 for a mutant strain of L. monocytogenes (DP-L1942) is similar in homozygous mice and controls (J:83180)
• following vaccination mice are able to develop resistance to L. monocytogenes infection (J:83180)
• dramatic increase in the number of infected cells expansion of the tissues infected following inoculation with Toxoplasma gondii (strain ME49) (J:110826)
• 5 days after inoculation with T. gondii (strain ME49) peritoneal exudates contain a more pronounced increase in the numbers of granulocytes, eosinophils, and mast cells compared to similarly infected wild-type controls (J:110826)
• IL-2 production in response to infection is similar to controls (J:110826)
• dramatic increase in the number of infected cells expansion of the tissues infected following inoculation with Toxoplasma gondii (strain ME49) (J:110826)
• 5 days after inoculation with T. gondii (strain ME49) peritoneal exudates contain a more pronounced increase in the numbers of granulocytes, eosinophils, and mast cells compared to similarly infected wild-type controls (J:110826)
• IL-2 production in response to infection is similar to controls (J:110826)
• die within 9 days of inoculation with T. gondii (strain ME49) unlike controls which survive more than 30 days (J:110826)
• highly susceptible to the normally avirulent T. gondii isolate, ts4 (J:110826)
• die within 9 days of inoculation with T. gondii (strain ME49) unlike controls which survive more than 30 days (J:110826)
• highly susceptible to the normally avirulent T. gondii isolate, ts4 (J:110826)

tumorigenesis
N
• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice on a BALB/c background do not develop disseminated lymphomas (J:77491)
• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice on a BALB/c background do not develop disseminated lymphomas (J:77491)
• in a few mice, with a very late onset (J:77491)
• all are well differentiated papillary adenocarcinomas (J:77491)
• in a few mice, with a very late onset (J:77491)
• all are well differentiated papillary adenocarcinomas (J:77491)
• Background Sensitivity: in mice on a BALB/c background compared to mice on a C57BL/6 background (J:77491)
• Background Sensitivity: in mice on a BALB/c background compared to mice on a C57BL/6 background (J:77491)

hematopoietic system
• IgG responses are restricted to IgG1 and IgG2b (J:45665)
• IgG responses are restricted to IgG1 and IgG2b (J:45665)




Genotype
MGI:3693883
hm5
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls (J:110856)
• treatment with exogenous IFNG improves survival (J:110856)
• mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls (J:110856)
• treatment with exogenous IFNG improves survival (J:110856)
• more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 105 TCID50 (50% tissue culture infective dose) infectious particles die (J:29170)
• more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 105 TCID50 (50% tissue culture infective dose) infectious particles die (J:29170)

immune system
• in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice (J:29170)
• in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice (J:29170)
• following infection with type A influenza (J:110721)
• following infection with type A influenza (J:110721)
• activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells (J:73948)
• activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells (J:73948)
• T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells (J:112600)
• T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells (J:112600)
• the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls (J:29170)
• the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls (J:29170)
• following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells (J:132905)
• following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells (J:132905)
• the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls (J:29170)
• the magnitude of the delayed type hypersensitive response in mice after HSV-1 infection is reduced compared to BALB/c wild-type controls (J:29170)
• display an increased IgG1 antibody response to type A influenza infection (J:110721)
• display an increased IgG1 antibody response to type A influenza infection (J:110721)
• 14 days after infection with virulent Mycobacterium tuberculosis serum levels of reactive nitrogen intermediates are very low, unlike in wild-type controls (J:110856)
• 14 days after infection with virulent Mycobacterium tuberculosis serum levels of reactive nitrogen intermediates are very low, unlike in wild-type controls (J:110856)
• at 14 days after infection with virulent Mycobacterium tuberculosis, 10- 100 fold more viable bacteria are found in the organs compared to organs of wild-type controls (J:110856)
• at 14 days after infection with virulent Mycobacterium tuberculosis, about 90% of the granulomas in the liver and 20% of the granulomas in the spleen are necrotic (J:110856)
• treatment with exogenous IFNG decreases the bacterial load (J:110856)
• at 14 days after infection with virulent Mycobacterium tuberculosis, 10- 100 fold more viable bacteria are found in the organs compared to organs of wild-type controls (J:110856)
• at 14 days after infection with virulent Mycobacterium tuberculosis, about 90% of the granulomas in the liver and 20% of the granulomas in the spleen are necrotic (J:110856)
• treatment with exogenous IFNG decreases the bacterial load (J:110856)
• mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls (J:110856)
• treatment with exogenous IFNG improves survival (J:110856)
• mean survival time following infecting with virulent Mycobacterium tuberculosis is 15 days compared to over 60 days for wild-type controls (J:110856)
• treatment with exogenous IFNG improves survival (J:110856)
• at 5 - 8 days post infection mice develop more severe conjunctivitis, periocular skin lesions, corneal opacity, and anterior chamber exudate following infection with HSV-1 relative to wld-type BALB/c controls infected with a higher dose of virus (J:29170)
• infectious virus is detected up to 10 days post infection with HSV-1 in mutants compared to up to 4 or days post infection in wild-type BAL/c mice or littermate controls, respectively (J:29170)
• at 5 - 8 days post infection mice develop more severe conjunctivitis, periocular skin lesions, corneal opacity, and anterior chamber exudate following infection with HSV-1 relative to wld-type BALB/c controls infected with a higher dose of virus (J:29170)
• infectious virus is detected up to 10 days post infection with HSV-1 in mutants compared to up to 4 or days post infection in wild-type BAL/c mice or littermate controls, respectively (J:29170)
• more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 105 TCID50 (50% tissue culture infective dose) infectious particles die (J:29170)
• more than 70% of mice infected on the cornea with herpes simplex virus type 1 (HSV-1) at a dose of 105 TCID50 (50% tissue culture infective dose) infectious particles die (J:29170)

vision/eye
• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice (J:114973)
• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice (J:114973)

homeostasis/metabolism
• T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells (J:112600)
• T cells from mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide show more IL-17a expressing cells and greater IL-17a production after MOG restimulation than controls; IL-4 is not detectable in these cells (J:112600)

cardiovascular system
• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice (J:114973)
• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice (J:114973)

hematopoietic system
• in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice (J:29170)
• in mice with acute or chronic HSV-1 infection the ratio of IgG2a to IgG1 is dramatically reduced compared to BALB/c wild-type mice (J:29170)
• following infection with type A influenza (J:110721)
• following infection with type A influenza (J:110721)
• activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells (J:73948)
• activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells (J:73948)




Genotype
MGI:4843967
hm6
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd * A/WySn * C57BL/10SnSg * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• relative to wild-type controls (J:119207)
• however, mercury treatment does not result in an increase in IgG1 levels (J:119207)
• relative to wild-type controls (J:119207)
• however, mercury treatment does not result in an increase in IgG1 levels (J:119207)
• decrease in the induction of IgG in response to low levels of antigen ((4-hydroxy-3 nitrophenyl)acetyl) (J:119207)
• decrease in the induction of IgG in response to low levels of antigen ((4-hydroxy-3 nitrophenyl)acetyl) (J:119207)
• following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice (J:119207)
• following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice (J:119207)
• resistant to mercury induced autoimmune response (J:119207)
• resistant to mercury induced autoimmune response (J:119207)

homeostasis/metabolism
• resistant to mercury induced autoimmune response (J:119207)
• resistant to mercury induced autoimmune response (J:119207)

hematopoietic system
• relative to wild-type controls (J:119207)
• however, mercury treatment does not result in an increase in IgG1 levels (J:119207)
• relative to wild-type controls (J:119207)
• however, mercury treatment does not result in an increase in IgG1 levels (J:119207)
• decrease in the induction of IgG in response to low levels of antigen ((4-hydroxy-3 nitrophenyl)acetyl) (J:119207)
• decrease in the induction of IgG in response to low levels of antigen ((4-hydroxy-3 nitrophenyl)acetyl) (J:119207)
• following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice (J:119207)
• following exposure to HgCl2 for 4 weeks, relative to similarly treated wild-type and heterozygous mice (J:119207)




Genotype
MGI:4838445
hm7
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• no difference in survival, tissue damage or spread of infection following infection with the opportunistic fungal pathogen Candida albicans is detected relative to wild-type controls (J:39881)
• no difference in survival, tissue damage or spread of infection following infection with the opportunistic fungal pathogen Candida albicans is detected relative to wild-type controls (J:39881)
• ovalbumin challenge fails to significantly potentiate ovalbumin specific IgE levels, unlike in wild-type controls (J:114213)
• ovalbumin challenge fails to significantly potentiate ovalbumin specific IgE levels, unlike in wild-type controls (J:114213)
• the eosinophilic response in ovalbumin challenged mice is reduced compared to wild-type controls (J:114213)
• the eosinophilic response in ovalbumin challenged mice is reduced compared to wild-type controls (J:114213)
• mice are able to clear infectious Murine gammaherpesvirus 68 (MHV-68) from their lungs but with a slight delay relative wild-type mice (J:39478)
• no differences are detected in the frequency of latently infected cells, the generation of cytotoxic T cells, the infection induced cytokine profile, or the recruitment or proliferation of cells into inflammatory sites (J:39478)
• mice are able to clear infectious Murine gammaherpesvirus 68 (MHV-68) from their lungs but with a slight delay relative wild-type mice (J:39478)
• no differences are detected in the frequency of latently infected cells, the generation of cytotoxic T cells, the infection induced cytokine profile, or the recruitment or proliferation of cells into inflammatory sites (J:39478)

respiratory system
• ovalbumin challenge fails to induce airway hyperresponsiveness unlike in wild-type mice (J:114213)
• ovalbumin challenge fails to induce airway hyperresponsiveness unlike in wild-type mice (J:114213)
• in saline challenged mice relative to wild-type controls (J:114213)
• in saline challenged mice relative to wild-type controls (J:114213)

hematopoietic system
• ovalbumin challenge fails to significantly potentiate ovalbumin specific IgE levels, unlike in wild-type controls (J:114213)
• ovalbumin challenge fails to significantly potentiate ovalbumin specific IgE levels, unlike in wild-type controls (J:114213)




Genotype
MGI:3587743
hm8
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice are able to clear infections of Pneumocystis carinii, similar to controls (J:119206)
• mice are able to clear infections of Pneumocystis carinii, similar to controls (J:119206)
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A (J:66802)
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A (J:66802)
• significantly lower resting splenic NK cell activity (J:66802)
• significantly lower resting splenic NK cell activity (J:66802)
• recruitment of NK cells to the liver by recombinant murine IL12 is impaired (J:115033)
• however, the recruitment of T cells by IL12 is not impaired (J:115033)
• recruitment of NK cells to the liver by recombinant murine IL12 is impaired (J:115033)
• however, the recruitment of T cells by IL12 is not impaired (J:115033)
• macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge (J:66802)
• macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge (J:66802)
• macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge (J:66802)
• macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge (J:66802)
• macrophages from BCG infected mice exhibit reduced class II expression (J:66802)
• macrophages from BCG infected mice exhibit reduced class II expression (J:66802)
• exposure to UVA and UVB fails to significantly reduce the UVB induced suppression of the type IV hypersensitivity reaction (J:55740)
• however, the type IV hypersensitivity reaction in the absence of UV exposure is similar to controls (J:55740)
• exposure to UVA and UVB fails to significantly reduce the UVB induced suppression of the type IV hypersensitivity reaction (J:55740)
• however, the type IV hypersensitivity reaction in the absence of UV exposure is similar to controls (J:55740)
• increased mortality following a sublethal dose of Mycobacterium bovis (BCG ) (J:66802)
• increased mortality following a sublethal dose of Mycobacterium bovis (BCG ) (J:66802)
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice (J:189794)
• however, IFNG-competent alpha+CD4+ T cells promote experimental cerebral malaria (J:189794)
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice (J:189794)
• however, IFNG-competent alpha+CD4+ T cells promote experimental cerebral malaria (J:189794)
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice (J:189794)
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice (J:189794)
• reduced surival of cardiac grafts relative to controls (J:44346)
• reduced surival of cardiac grafts relative to controls (J:44346)

tumorigenesis
• following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice (J:152785)
• following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice (J:152785)
• tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells show increased tumor rejection compared to controls (J:138466)
• tumor-bearing mice treated with Th-17-polarized cells from Tg(Tcra,Tcrb)9Rest cells show increased tumor rejection compared to controls (J:138466)

craniofacial
• modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks (J:147935)
• modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks (J:147935)

skeleton
• modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks (J:147935)
• modest increase in alveolar bone loss at 30 weeks relative to mice at 6 and 16 weeks (J:147935)

hematopoietic system
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A (J:66802)
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A (J:66802)
• significantly lower resting splenic NK cell activity (J:66802)
• significantly lower resting splenic NK cell activity (J:66802)
• recruitment of NK cells to the liver by recombinant murine IL12 is impaired (J:115033)
• however, the recruitment of T cells by IL12 is not impaired (J:115033)
• recruitment of NK cells to the liver by recombinant murine IL12 is impaired (J:115033)
• however, the recruitment of T cells by IL12 is not impaired (J:115033)
• macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge (J:66802)
• macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge (J:66802)
• macrophages from BCG infected mice fail to produce nitric oxide in response to LPS challenge (J:66802)
• macrophages from BCG infected mice exhibit reduced production of superoxide anion in response to PMA challenge (J:66802)
• macrophages from BCG infected mice exhibit reduced class II expression (J:66802)
• macrophages from BCG infected mice exhibit reduced class II expression (J:66802)

integument
• following exposure to UVA and UVB mice fail to develop significant erythema unlike wild-type controls (J:55740)
• however, the increase in skin fold thickness in response to UVB or UVA and UVB exposure is not significantly different from controls (J:55740)
• following exposure to UVA and UVB mice fail to develop significant erythema unlike wild-type controls (J:55740)
• however, the increase in skin fold thickness in response to UVB or UVA and UVB exposure is not significantly different from controls (J:55740)

cellular
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A (J:66802)
• splenocytes from BCG infected mice exhibit increased proliferation in response to Con A (J:66802)

mortality/aging
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice (J:189794)
• mice infected with Plasmodium berghei ANKA are protected from development of experimental cerebral malaria and survive longer than wild-type mice (J:189794)

Mouse Models of Human Disease
OMIM ID Ref(s)
Malaria, Susceptibility to 611162 J:189794




Genotype
MGI:4838441
hm9
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• after infection with a normally sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice become severely ill and need to be euthanized (J:15723)
• after infection with a normally sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice become severely ill and need to be euthanized (J:15723)

immune system
• following infection with a sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice develop widespread infection with high numbers of bacteria in multiple tissues and obvious bacteremia (J:15723)
• by 4 weeks after aerosol infection with the virulent Erdam strain of Mycobacterium tuberculosis mice display multifocal necrotic areas contain high numbers of bacteria in the spleen, liver, lungs and kidneys (J:15723)
• following infection with a sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice develop widespread infection with high numbers of bacteria in multiple tissues and obvious bacteremia (J:15723)
• by 4 weeks after aerosol infection with the virulent Erdam strain of Mycobacterium tuberculosis mice display multifocal necrotic areas contain high numbers of bacteria in the spleen, liver, lungs and kidneys (J:15723)
• after infection with a normally sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice become severely ill and need to be euthanized (J:15723)
• after infection with a normally sublethal dose of the virulent Erdam strain of Mycobacterium tuberculosis mice become severely ill and need to be euthanized (J:15723)




Genotype
MGI:4839050
hm10
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• older mice appear to be protected from end organ disease relative to wild-type controls (J:39600)
• older mice appear to be protected from end organ disease relative to wild-type controls (J:39600)
• levels of anti-snRNP antibodies are decreased at 3 but not at 7-8 months of age relative to wild-type controls (J:39600)
• levels of anti-snRNP antibodies are decreased at 3 but not at 7-8 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 7 -8 months of age levels of anti-dsDNA antibodies are similar to wild-type controls but these antibodies fail to bind dsDNA containing kinetoplast of Crithidia luciliae substrates suggesting the antibodies are of low affinity (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 7 -8 months of age levels of anti-dsDNA antibodies are similar to wild-type controls but these antibodies fail to bind dsDNA containing kinetoplast of Crithidia luciliae substrates suggesting the antibodies are of low affinity (J:39600)

hematopoietic system
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)
• at 3 months of age relative to wild-type controls (J:39600)




Genotype
MGI:4838444
hm11
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• Background Sensitivity: at generation N4 no difference is seen in the time course of diabetes development in females unlike in mice at generation N7 (J:33427)
• Background Sensitivity: at generation N4 no difference is seen in the time course of diabetes development in females unlike in mice at generation N7 (J:33427)




Genotype
MGI:3623449
hm12
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
NOD.129S7(B6)-Ifngtm1Ts/DvsJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis (J:72818)
• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis (J:72818)
• when diabetic NOD splenocytes are transferred into mutant NOD mice, only 33% develop diabetes over the course of the observation period (J:72818)
• when diabetic NOD splenocytes are transferred into mutant NOD mice, only 33% develop diabetes over the course of the observation period (J:72818)

endocrine/exocrine glands
• islet cells from Ifng-deficient NOD mice are less susceptible to insulin-specific CD8+ cell-induced toxicity (J:72818)
• islet cells from Ifng-deficient NOD mice are less susceptible to insulin-specific CD8+ cell-induced toxicity (J:72818)

hematopoietic system
• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis (J:72818)
• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis (J:72818)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:72818




Genotype
MGI:3623448
hm13
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
NOD.129S7(B6)-Ifngtm1Ts Prkdcscid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when diabetic NOD splenocytes are transferred into mutant NOD.scid mice only 23% of recipients become diabetic (determined by monitoring urine glucose level) 7 weeks after transfer, but 100% of wild-type NOD.Scid mice are diabetic within 5 weeks (J:72818)
• when diabetic NOD splenocytes are transferred into mutant NOD.scid mice only 23% of recipients become diabetic (determined by monitoring urine glucose level) 7 weeks after transfer, but 100% of wild-type NOD.Scid mice are diabetic within 5 weeks (J:72818)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:72818




Genotype
MGI:3622412
hm14
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
NOD.129S7-Ifngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Background Sensitivity: delay in the development of diabetes in females at generation N7 but not a generation N4 (J:33427)
• however, the ultimate penetrance of the diabetes phenotype does not differ from wild-type controls and no gross differences in pancreatic inflammation are detected (J:33427)
• Background Sensitivity: delay in the development of diabetes in females at generation N7 but not a generation N4 (J:33427)
• however, the ultimate penetrance of the diabetes phenotype does not differ from wild-type controls and no gross differences in pancreatic inflammation are detected (J:33427)
• null animals challenged with CVB4 at 8 weeks of age show a retarded rate of diabetes (2 consecutive blood glucose measures >240 mg/dl) development compared to saline-treated controls; over the 25-week follow up period, about 30% of CVB4-exposed nulls develop disease versus around 90% of aline-treated controls (J:95105)
• null animals challenged with CVB4 at 8 weeks of age show a retarded rate of diabetes (2 consecutive blood glucose measures >240 mg/dl) development compared to saline-treated controls; over the 25-week follow up period, about 30% of CVB4-exposed nulls develop disease versus around 90% of aline-treated controls (J:95105)




Genotype
MGI:5514242
cn15
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129 * C57BL/6 * DBA/2 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Tg(Cd4-cre)1Cwi mutation (4 available)
Tgfbr2tm1.2Hlm mutation (0 available); any Tgfbr2 mutation (4 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• improved survival (J:196160)
• improved survival (J:196160)

immune system
N
• do not develop diabetes (J:196160)
• do not develop diabetes (J:196160)




Genotype
MGI:5448156
cn16
Allelic
Composition
Foxo1tm1Flv/Foxo1tm1Flv
Ifngtm1Ts/Ifngtm1Ts
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Flv mutation (0 available); any Foxo1 mutation (7 available)
Foxp3tm4(YFP/icre)Ayr mutation (1 available); any Foxp3 mutation (30 available)
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• the lethal inflammatory phenotype is partially rescued (J:189962)
• the lethal inflammatory phenotype is partially rescued (J:189962)

immune system
N
• regulatory T cells are able to suppress development of colitis in Rag1 null mice receiving na[?]ve T cells (J:189962)
• regulatory T cells are able to suppress development of colitis in Rag1 null mice receiving na[?]ve T cells (J:189962)
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3/Foxp3+ mice (J:189962)
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3/Foxp3+ mice (J:189962)
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3/Foxp3+ mice (J:189962)
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3/Foxp3+ mice (J:189962)

hematopoietic system
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3/Foxp3+ mice (J:189962)
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3/Foxp3+ mice (J:189962)
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3/Foxp3+ mice (J:189962)
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3/Foxp3+ mice (J:189962)




Genotype
MGI:4938323
cx17
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
B6.129-Apoetm1Unc Ifngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (22 available); any Apoe mutation (64 available)
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 50% of mice infused with angiotensin-II die within 2 to 10 days due to rupture of the abdominal aorta compared to 0 deaths of mutant mice wild-type for Ifng (J:166204)
• about 50% of mice infused with angiotensin-II die within 2 to 10 days due to rupture of the abdominal aorta compared to 0 deaths of mutant mice wild-type for Ifng (J:166204)

cardiovascular system
• about 50% of mice infused with 1000 ng/kg*min angiotensin-II die within 2 to 10 days due to rupture of the abdominal aorta compared to 0 deaths of mutant mice wild-type for Ifng (J:166204)
• increase in the incidence of abdominal aorta aneurysyms in in mice infused with 500 ng/kg*min angiotensin-II compared to mutant mice wild-type for Ifng (J:166204)
• about 50% of mice infused with 1000 ng/kg*min angiotensin-II die within 2 to 10 days due to rupture of the abdominal aorta compared to 0 deaths of mutant mice wild-type for Ifng (J:166204)
• increase in the incidence of abdominal aorta aneurysyms in in mice infused with 500 ng/kg*min angiotensin-II compared to mutant mice wild-type for Ifng (J:166204)
• increase in the suprarenal aortic diameter in mice infused with 500 ng/kg*min angiotensin-II compared to mutant mice wild-type for Ifng (J:166204)
• increase in the suprarenal aortic diameter in mice infused with 500 ng/kg*min angiotensin-II compared to mutant mice wild-type for Ifng (J:166204)

growth/size/body
• compared to mutant mice wild-type for Ifng (J:166204)
• compared to mutant mice wild-type for Ifng (J:166204)




Genotype
MGI:4867042
cx18
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129S7-Ldlrtm1Her Ifngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after 8 or 20 weeks on a cholesterol diet aortic lesion size is reduced compared to mice homozygous for Ldlrtm1Her alone (J:103072)
• after 8 or 20 weeks on a cholesterol diet aortic lesion size is reduced compared to mice homozygous for Ldlrtm1Her alone (J:103072)

hematopoietic system
• increase in the proportion of T cells in the blood relative to controls homozygous for Ldlrtm1Her alone (J:103072)
• increase in the proportion of T cells in the blood relative to controls homozygous for Ldlrtm1Her alone (J:103072)

immune system
• increase in the proportion of T cells in the blood relative to controls homozygous for Ldlrtm1Her alone (J:103072)
• increase in the proportion of T cells in the blood relative to controls homozygous for Ldlrtm1Her alone (J:103072)




Genotype
MGI:5431918
cx19
Allelic
Composition
Csf2tm1Mlg/Csf2tm1Mlg
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli
Genetic
Background
B6.129S-Csf2tm1Mlg Il3tm1Glli Ifngtm1TsIfngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2tm1Mlg mutation (1 available); any Csf2 mutation (11 available)
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Il3tm1Glli mutation (1 available); any Il3 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• significantly reduced fasting blood sugar, to levels similar to controls (J:145518)
• improved glucose tolerance (J:145518)
• significantly reduced fasting blood sugar, to levels similar to controls (J:145518)
• improved glucose tolerance (J:145518)

tumorigenesis
• islet adenomas (J:145518)
• islet adenomas (J:145518)




Genotype
MGI:3721950
cx20
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic
Background
C.129-Ifngtm1Ts Tgfb1tm1Doe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Tgfb1tm1Doe mutation (4 available); any Tgfb1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice survive average of 32.9 days (range 23-66 days) (J:69346)
• mice survive average of 32.9 days (range 23-66 days) (J:69346)

growth/size/body
• mice are smaller than littermate controls (J:69346)
• mice are smaller than littermate controls (J:69346)

liver/biliary system
N
• outwardly, livers show no visible abnormalities (J:69346)
• outwardly, livers show no visible abnormalities (J:69346)
• on necropsy, modest inflammatory expansion around portal tracts is observed in some animals (J:69346)
• on necropsy, modest inflammatory expansion around portal tracts is observed in some animals (J:69346)

immune system
• on necropsy, modest inflammatory expansion around portal tracts is observed in some animals (J:69346)
• on necropsy, modest inflammatory expansion around portal tracts is observed in some animals (J:69346)

homeostasis/metabolism
• in 4/5 mice >21 days of age, ALT plasma levels are elevated (J:69346)
• in 4/5 mice >21 days of age, ALT plasma levels are elevated (J:69346)




Genotype
MGI:4867045
cx21
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Prf1tm1Sdz/Prf1tm1Sdz
Genetic
Background
C.Cg-Prf1tm1Sdz Ifngtm1Ts
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Prf1tm1Sdz mutation (8 available); any Prf1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

tumorigenesis
• some lymphomas have an unusual histiocytic appearance with a pale eosinophilic cytoplasm (J:77491)
• some lymphomas have an unusual histiocytic appearance with a pale eosinophilic cytoplasm (J:77491)
• incidence is increased and onset is earlier compared to mice homozygous for Prf1tm1Sdz alone (J:77491)
• incidence is increased and onset is earlier compared to mice homozygous for Prf1tm1Sdz alone (J:77491)
• incidence is increased and onset is earlier compared to mice homozygous for Prf1tm1Sdz alone (J:77491)
• incidence is increased and onset is earlier compared to mice homozygous for Prf1tm1Sdz alone (J:77491)




Genotype
MGI:4843969
cx22
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Tnfrsf1atm1Blt mutation (5 available); any Tnfrsf1a mutation (22 available)
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• despite the absence of germinal centers the white pulp has distinct T and B cell areas (J:119206)
• despite the absence of germinal centers the white pulp has distinct T and B cell areas (J:119206)
• grossly unidentifiable and histologically hypoplastic (J:119206)
• grossly unidentifiable and histologically hypoplastic (J:119206)
• thin and lack primary and secondary cortical follicles (J:119206)
• thin and lack primary and secondary cortical follicles (J:119206)
• absent (J:119206)
• absent (J:119206)
• absent (J:119206)
• absent (J:119206)
• develop severe inflammation 4 weeks after infection with Pneumocystis carinii (J:119206)
• develop severe inflammation 4 weeks after infection with Pneumocystis carinii (J:119206)
• 4 weeks after infection with Pneumocystis carinii lungs demonstrate severe infection indicating mice are unable to clear the infection (J:119206)
• 4 weeks after infection with Pneumocystis carinii pulmonary lavages contain about 10 fold higher numbers of leukocytes compared to similarly infected control mice (J:119206)
• 4 weeks after infection with Pneumocystis carinii lungs demonstrate severe infection indicating mice are unable to clear the infection (J:119206)
• 4 weeks after infection with Pneumocystis carinii pulmonary lavages contain about 10 fold higher numbers of leukocytes compared to similarly infected control mice (J:119206)

hematopoietic system
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls (J:119206)
• despite the absence of germinal centers the white pulp has distinct T and B cell areas (J:119206)
• despite the absence of germinal centers the white pulp has distinct T and B cell areas (J:119206)

respiratory system
• develop severe inflammation 4 weeks after infection with Pneumocystis carinii (J:119206)
• develop severe inflammation 4 weeks after infection with Pneumocystis carinii (J:119206)




Genotype
MGI:4850158
cx23
Allelic
Composition
Ifngtm1Ts/Ifng+
Socs1tm1Wehi/Socs1tm1Wehi
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Socs1tm1Wehi mutation (0 available); any Socs1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 8 of 12 mice died between 2 and 12 weeks of age, the remaining 4 survived (J:57474)
• 8 of 12 mice died between 2 and 12 weeks of age, the remaining 4 survived (J:57474)
• 8 of 12 mice died between 2 and 12 weeks of age, the remaining 4 survived (J:57474)
• 8 of 12 mice died between 2 and 12 weeks of age, the remaining 4 survived (J:57474)




Genotype
MGI:4430638
cx24
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Wehi/Socs1tm1Wehi
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Socs1tm1Wehi mutation (0 available); any Socs1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike mice homozygous for Socs1tm1Wehi alone, double homozygous mice survive past weaning and are overtly healthy (J:57474)
• unlike mice homozygous for Socs1tm1Wehi alone, double homozygous mice survive past weaning and are overtly healthy (J:57474)
• lethality observed in Socs1tm1Wehi homozygotes is rescued (J:70408)
• lethality observed in Socs1tm1Wehi homozygotes is rescued (J:70408)

reproductive system
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, proliferation of mammary epithelium is normal (J:70408)
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, proliferation of mammary epithelium is normal (J:70408)

endocrine/exocrine glands
• 8 of 12 mice have enlarged medulla (J:57474)
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal (J:57474)
• 8 of 12 mice have enlarged medulla (J:57474)
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal (J:57474)
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, proliferation of mammary epithelium is normal (J:70408)
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, proliferation of mammary epithelium is normal (J:70408)
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, lobuloalveolar density returns to normal by day 5 of lactation (J:70408)
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, lobuloalveolar density returns to normal by day 5 of lactation (J:70408)
• at day 18 of pregnancy, mammary glands produce more milk than in wild-type mice (J:70408)
• at day 18 of pregnancy, mammary glands produce more milk than in wild-type mice (J:70408)

cardiovascular system
• 2 of 12 mice show lymphoid cuffing of the lung vessels (J:57474)
• 2 of 12 mice show lymphoid cuffing of the lung vessels (J:57474)

hematopoietic system
N
• unlike mice homozygous for Socs1tm1Wehi alone, no hematological abnormalities are detected at 3 weeks of age (J:57474)
• unlike mice homozygous for Socs1tm1Wehi alone, no hematological abnormalities are detected at 3 weeks of age (J:57474)
• 8 of 12 mice have enlarged medulla (J:57474)
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal (J:57474)
• 8 of 12 mice have enlarged medulla (J:57474)
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal (J:57474)

immune system
• 8 of 12 mice have enlarged medulla (J:57474)
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal (J:57474)
• 8 of 12 mice have enlarged medulla (J:57474)
• however, unlike mice homozygous for Socs1tm1Wehi alone, the cortex is normal (J:57474)

respiratory system
• 2 of 12 mice show lymphoid cuffing of the lung vessels (J:57474)
• 2 of 12 mice show lymphoid cuffing of the lung vessels (J:57474)

integument
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, proliferation of mammary epithelium is normal (J:70408)
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, proliferation of mammary epithelium is normal (J:70408)
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, lobuloalveolar density returns to normal by day 5 of lactation (J:70408)
• from day 16 of pregnancy, mice exhibit a higher density of lobuloalveolar units compared with wild-type mice (J:70408)
• however, lobuloalveolar density returns to normal by day 5 of lactation (J:70408)
• at day 18 of pregnancy, mammary glands produce more milk than in wild-type mice (J:70408)
• at day 18 of pregnancy, mammary glands produce more milk than in wild-type mice (J:70408)




Genotype
MGI:3586344
cx25
Allelic
Composition
Csf2tm1Dran/Csf2tm1Dran
Ifngtm1Ts/Ifngtm1Ts
Il3tm1Glli/Il3tm1Glli
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2tm1Dran mutation (0 available); any Csf2 mutation (11 available)
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Il3tm1Glli mutation (1 available); any Il3 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 40% of homozygotes died of pneumonia in the first few weeks of life (J:83086)
• about 40% of homozygotes died of pneumonia in the first few weeks of life (J:83086)
• surviving mice became moribund with time (J:83086)
• most died or had to be euthanized before 14 months of age (J:83086)
• surviving mice became moribund with time (J:83086)
• most died or had to be euthanized before 14 months of age (J:83086)

immune system
• mild eosinophilia in mice surviving beyond the first few weeks of life (J:83086)
• mild eosinophilia in mice surviving beyond the first few weeks of life (J:83086)
• serum levels increased but not significantly (J:83086)
• serum levels increased but not significantly (J:83086)
• significantly higher serum IgG1 levels (J:83086)
• non significant increases in serum IgG2b levels (J:83086)
• significantly higher serum IgG1 levels (J:83086)
• non significant increases in serum IgG2b levels (J:83086)
• acute and chronic inflammatory reactions found in many organs and tissues (J:83086)
• acute and chronic inflammatory reactions found in many organs and tissues (J:83086)

tumorigenesis
• Lymphoproliferative disease in a high proportion of mice (J:83086)
• develops into B cell lymphomas (J:83086)
• Lymphoproliferative disease in a high proportion of mice (J:83086)
• develops into B cell lymphomas (J:83086)
• solid tumors are benign to metastasizing carcinomas (J:83086)
• solid tumors are benign to metastasizing carcinomas (J:83086)
• particularly prevalent (J:83086)
• particularly prevalent (J:83086)

hematopoietic system
• mild eosinophilia in mice surviving beyond the first few weeks of life (J:83086)
• mild eosinophilia in mice surviving beyond the first few weeks of life (J:83086)
• serum levels increased but not significantly (J:83086)
• serum levels increased but not significantly (J:83086)
• significantly higher serum IgG1 levels (J:83086)
• non significant increases in serum IgG2b levels (J:83086)
• significantly higher serum IgG1 levels (J:83086)
• non significant increases in serum IgG2b levels (J:83086)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Systemic Lupus Erythematosus; SLE 152700 J:83086




Genotype
MGI:3783715
cx26
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Socs1tm1Jni/Socs1tm1Jni
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Socs1tm1Jni mutation (0 available); any Socs1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells (J:132905)
• following culturing of IL-17 producing T cells in vitro, IL-17 production is twice as high as in similarly treated wild-type cells (J:132905)




Genotype
MGI:5474288
cx27
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Nlrp1aNeut1/Nlrp1aNeut1
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Nlrp1aNeut1 mutation (0 available); any Nlrp1a mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal blood neutrophils and survival (J:191055)
• normal blood neutrophils and survival (J:191055)
• develop encephalitis (J:191055)
• develop encephalitis (J:191055)

nervous system
• develop encephalitis (J:191055)
• develop encephalitis (J:191055)




Genotype
MGI:5688500
cx28
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Tg(SFTPC-Il18)AThos/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Tg(SFTPC-Il18)AThos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice (J:147547)
• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice (J:147547)

respiratory system
• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice (J:147547)
• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice (J:147547)
• the mean alveolar chord length is greater than in wild-type mice and single Tg(SFTPC-Il18)AThos transgenic mice (J:147547)
• the mean alveolar chord length is greater than in wild-type mice and single Tg(SFTPC-Il18)AThos transgenic mice (J:147547)
• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice (J:147547)
• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice (J:147547)
• lung volume is higher than in wild-type or single transgenic mice (J:147547)
• lung volume is higher than in wild-type or single transgenic mice (J:147547)




Genotype
MGI:4839049
cx29
Allelic
Composition
Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (24 available); any Fas mutation (47 available)
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• decrease in the number of CD4-CD8-B220+ alpha beta T cells compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• decrease in the number of CD4-CD8-B220+ alpha beta T cells compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 7-8 months of age a modest increase in spleen size and cellularity is seen relative to wild-type controls (J:39600)
• at 7-8 months of age a modest increase in spleen size and cellularity is seen relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• lympadenopathy (based on lymph node weight and cellularity) is reduced compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• in young animals lymph node size is similar to wild-type controls (J:39600)
• lympadenopathy (based on lymph node weight and cellularity) is reduced compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• in young animals lymph node size is similar to wild-type controls (J:39600)
• at 7-8 months of age a modest increase in lymph node size and cellularity is seen relative to wild-type controls (J:39600)
• at 7-8 months of age a modest increase in lymph node size and cellularity is seen relative to wild-type controls (J:39600)
• while mice develop the typical autoimmune lesions, end organ disease is decreased compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• while mice develop the typical autoimmune lesions, end organ disease is decreased compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• lower titers of anti-snRNP and anti-rheumatoid factors antibodies relative to mice homozygous for Faslpr and wild-type for Ifng at 3 and 7-8 months of age (J:39600)
• lower titers of anti-snRNP and anti-rheumatoid factors antibodies relative to mice homozygous for Faslpr and wild-type for Ifng at 3 and 7-8 months of age (J:39600)
• at 3 and 7-8 months of age (J:39600)
• at 3 and 7-8 months of age (J:39600)
• at 3 and 7-8 months of age (J:39600)
• at 3 and 7-8 months of age (J:39600)

homeostasis/metabolism
• levels are lower compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• levels are lower compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)

hematopoietic system
• decrease in the number of CD4-CD8-B220+ alpha beta T cells compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• decrease in the number of CD4-CD8-B220+ alpha beta T cells compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• lympadenopathy (based on spleen weight and cellularity) is reduced compared to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 7-8 months of age a modest increase in spleen size and cellularity is seen relative to wild-type controls (J:39600)
• at 7-8 months of age a modest increase in spleen size and cellularity is seen relative to wild-type controls (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)
• at 3 and 7-8 months of age relative to mice homozygous for Faslpr and wild-type for Ifng (J:39600)




Genotype
MGI:3629594
cx30
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• development and severity of IBD are similar to Tnftm2Gkl/+, wild-type Ifng controls (J:108572)
• development and severity of IBD are similar to Tnftm2Gkl/+, wild-type Ifng controls (J:108572)

digestive/alimentary system
• development and severity of IBD are similar to Tnftm2Gkl/+, wild-type Ifng controls (J:108572)
• development and severity of IBD are similar to Tnftm2Gkl/+, wild-type Ifng controls (J:108572)




Genotype
MGI:3801419
cx31
Allelic
Composition
Faslpr/Faslpr
Ifngtm1Ts/Ifng+
Genetic
Background
MRL.Cg-Ifngtm1Ts Faslpr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (24 available); any Fas mutation (47 available)
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice become moribund and are sacrificed at 4 months mutants posttransfer of Ifng wild-type F4/80+ macrophages at 2 months while all controls remain alive (J:123834)
• mice become moribund and are sacrificed at 4 months mutants posttransfer of Ifng wild-type F4/80+ macrophages at 2 months while all controls remain alive (J:123834)

immune system
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• mice develop glomerular autoantibody deposits, but do not develop glomerulonephritis (J:123834)
• mice develop glomerular autoantibody deposits, but do not develop glomerulonephritis (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months develop diffuse proliferative glomerulonephritis by 6 months (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months develop diffuse proliferative glomerulonephritis by 6 months (J:123834)

renal/urinary system
• glomeruli are hypercellular in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)
• glomerular damage is more severe in mice receiving cell transfer than in control mice not receiving transfers (J:123834)
• glomeruli are hypercellular in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)
• glomerular damage is more severe in mice receiving cell transfer than in control mice not receiving transfers (J:123834)
• thickening of capillary walls in glomeruli is observed in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)
• thickening of capillary walls in glomeruli is observed in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months develop diffuse proliferative glomerulonephritis by 6 months (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months develop diffuse proliferative glomerulonephritis by 6 months (J:123834)
• mesangial cells are increased in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)
• mesangial cells are increased in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)

homeostasis/metabolism
• BUN levels are elevated at time of death in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)
• BUN levels are elevated at time of death in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)

cardiovascular system
• thickening of capillary walls in glomeruli is observed in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)
• thickening of capillary walls in glomeruli is observed in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months (J:123834)

cellular
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)

hematopoietic system
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)




Genotype
MGI:3801418
cx32
Allelic
Composition
Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts
Genetic
Background
MRL.Cg-Ifngtm1Ts Faslpr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (24 available); any Fas mutation (47 available)
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• at 4 months, kidney-infiltrating macrophages are not present; deposits of glomerular immune complexes (ICs) are not observed (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, IC deposition and glomerular proliferation are similar to control mice not receiving transfers (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months, kidney interstitium remains free of macrophages, T cells, or other lymphocytes (signs of kidney interstitial inflammation) at 2 months post-transfer (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months, anti-DNA autoantibody production is minimal compared to Ifng-wild-type, Faslpr homozygotes; glomerular autoantibody deposits are not observed (J:123834)
• at 4 months, kidney-infiltrating macrophages are not present; deposits of glomerular immune complexes (ICs) are not observed (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, IC deposition and glomerular proliferation are similar to control mice not receiving transfers (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months, kidney interstitium remains free of macrophages, T cells, or other lymphocytes (signs of kidney interstitial inflammation) at 2 months post-transfer (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months, anti-DNA autoantibody production is minimal compared to Ifng-wild-type, Faslpr homozygotes; glomerular autoantibody deposits are not observed (J:123834)
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes (J:123834)
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes (J:123834)
• mice display perivascular infiltrate composed mainly of CD4+ cells (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop heavy perivascular infiltrates of mainly CD4+ T cells but show no signs of glomerular nephritis, similar to nontransferred controls (J:123834)
• severe multifocal pyogranulomatous nephritis is observed in kidneys of mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months of age, with extensive perivascular and periglomerular accumulation of polymorphonuclear leukocytes and mononuclear cells (J:123834)
• mice display perivascular infiltrate composed mainly of CD4+ cells (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop heavy perivascular infiltrates of mainly CD4+ T cells but show no signs of glomerular nephritis, similar to nontransferred controls (J:123834)
• severe multifocal pyogranulomatous nephritis is observed in kidneys of mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months of age, with extensive perivascular and periglomerular accumulation of polymorphonuclear leukocytes and mononuclear cells (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop diffuse severe acidophilic pneumonia, characterized by intraalveolar accumulation of strongly eosinophilic macrophages with heavy CD3+ cell infiltration; some animals present with peribronchial T cell infiltration (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop diffuse severe acidophilic pneumonia, characterized by intraalveolar accumulation of strongly eosinophilic macrophages with heavy CD3+ cell infiltration; some animals present with peribronchial T cell infiltration (J:123834)

renal/urinary system
• mice display perivascular infiltrate composed mainly of CD4+ cells (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop heavy perivascular infiltrates of mainly CD4+ T cells but show no signs of glomerular nephritis, similar to nontransferred controls (J:123834)
• severe multifocal pyogranulomatous nephritis is observed in kidneys of mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months of age, with extensive perivascular and periglomerular accumulation of polymorphonuclear leukocytes and mononuclear cells (J:123834)
• mice display perivascular infiltrate composed mainly of CD4+ cells (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop heavy perivascular infiltrates of mainly CD4+ T cells but show no signs of glomerular nephritis, similar to nontransferred controls (J:123834)
• severe multifocal pyogranulomatous nephritis is observed in kidneys of mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months of age, with extensive perivascular and periglomerular accumulation of polymorphonuclear leukocytes and mononuclear cells (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, glomerular nephritis is not observed, but severe multifocal pyogranulomatous nephritis in kidneys is observed (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, glomerular nephritis is not observed, but severe multifocal pyogranulomatous nephritis in kidneys is observed (J:123834)

respiratory system
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop diffuse severe acidophilic pneumonia, characterized by intraalveolar accumulation of strongly eosinophilic macrophages with heavy CD3+ cell infiltration; some animals present with peribronchial T cell infiltration (J:123834)
• mutants receiving adoptive transfer of Ifng wild-type T cells at 2 months develop diffuse severe acidophilic pneumonia, characterized by intraalveolar accumulation of strongly eosinophilic macrophages with heavy CD3+ cell infiltration; some animals present with peribronchial T cell infiltration (J:123834)

cellular
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes (J:123834)
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes (J:123834)

hematopoietic system
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes (J:123834)
• macrophage accumulation is reduced compared to Faslpr homozygotes (J:123834)
• in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages, migration of macrophages to peritubular and periglomerular areas of kidneys is detected, whereas without transfer, macrophage recruitment to these areas is significantly reduced relative to Faslpr homozygotes (J:123834)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory