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Hbb-bh2 Gene Detail
Summary
  • Symbol
    Hbb-bh2
  • Name
    hemoglobin beta, bh2
  • Synonyms
    Gm5736
  • Feature Type
    protein coding gene
  • IDs
    MGI:96025
    NCBI Gene: 436003
  • Member of
    Hbb cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:103488331-103489727 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.85 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96025
 protein coding gene Chr7:103488008-103490418 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032684
 protein coding gene Chr7:107050781-107052028 (-)
A/J MGP_AJ_G0032657
 protein coding gene Chr7:104264450-104265697 (-)
AKR/J MGP_AKRJ_G0032590
 protein coding gene Chr7:106784348-106785595 (-)
BALB/cJ MGP_BALBcJ_G0032667
 protein coding gene Chr7:103995558-103996805 (-)
C3H/HeJ MGP_C3HHeJ_G0032378
 protein coding gene Chr7:107128202-107129449 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033163
 protein coding gene Chr7:111038293-111039575 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030159
 protein coding gene Chr7:106355520-106356800 (-)
CAST/EiJ MGP_CASTEiJ_G0031709
 protein coding gene Chr7:98681596-98682849 (-)
CBA/J MGP_CBAJ_G0032346
 protein coding gene Chr7:114966510-114967757 (-)
DBA/2J MGP_DBA2J_G0032500
 protein coding gene Chr7:102582987-102584234 (-)
FVB/NJ MGP_FVBNJ_G0032453
 protein coding gene Chr7:102306363-102307610 (-)
LP/J MGP_LPJ_G0032593
 protein coding gene Chr7:108370084-108371331 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032489
 protein coding gene Chr7:116293295-116294577 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033190
 protein coding gene Chr7:105974421-105975703 (-)
PWK/PhJ MGP_PWKPhJ_G0031423
 protein coding gene Chr7:95568821-95570067 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031267
 protein coding gene Chr7:93249051-93250333 (-)
WSB/EiJ MGP_WSBEiJ_G0031823
 protein coding gene Chr7:106701301-106702548 (-)



Homology
more
  • Human Ortholog
    HBB, hemoglobin subunit beta
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HBB, hemoglobin subunit beta
  • Synonyms
    beta-globin, CD113t-C, ECYT6
  • Links
    NCBI Gene ID: 3043
    neXtProt AC: NX_P68871
    UniProt: P68871

  • Chr Location
    11p15.4; chr11:5225464-5229395 (-)  GRCh38
  • Human Ortholog
    HBD, hemoglobin subunit delta
  • Synonyms
    HBK
  • Links
    NCBI Gene ID: 3045
    neXtProt AC: NX_P02042
    UniProt: P02042

  • Chr Location
    11p15.4; chr11:5232678-5243657 (-)  GRCh38
Human Diseases
more
  • Diseases
    13 with human HBB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
 View 17 models
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 7 models
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    921
  • Tissues
    40
  • cDNA Data
    2
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078621 Ensembl Gene Model | MGI Sequence Detail 1397 C57BL/6J ±  kb
transcript ENSMUST00000106866 Ensembl | MGI Sequence Detail 558 Not Applicable  
polypeptide ENSMUSP00000102479 Ensembl | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 8
    cDNA 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10637, MGI:3645277
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 15
  • Earliest
    J:6364 Jahn CL, et al., DNA sequence organization of the beta-globin complex in the BALB/c mouse. Cell. 1980 Aug;21(1):159-68
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory