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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chuk
conserved helix-loop-helix ubiquitous kinase
MGI:99484
147 phenotypes from 10 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chukem1(IMPC)Ccpcz/Chuk+
C57BL/6NCrl-Chukem1(IMPC)Ccpcz/Ccpcz 		abnormal digit morphology J:211773
abnormal eye morphology J:211773
abnormal lymph node morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
abnormal thymus morphology J:211773
abnormal tooth color J:211773
abnormal tooth morphology J:211773
abnormal uterus morphology J:211773
enlarged lymph nodes J:211773
enlarged thymus J:211773
hydrometra J:211773
increased circulating HDL cholesterol level J:211773
microphthalmia J:211773
small testis J:211773
Chukem1(IMPC)Ccpcz/Chukem1(IMPC)Ccpcz
C57BL/6NCrl-Chukem1(IMPC)Ccpcz/Ccpcz 		preweaning lethality, complete penetrance J:211773
Chuktm1.1Mpa/Chuktm1.1Mpa
involves: C57BL/6 		abnormal epidermal layer morphology J:122320
abnormal epidermis stratum basale morphology J:122320
abnormal head morphology J:122320
abnormal keratinocyte differentiation J:122320
abnormal limb morphology J:122320
abnormal presphenoid bone morphology J:122320
abnormal skeleton morphology J:122320
abnormal tail morphology J:122320
abnormal vomer bone morphology J:122320
abnormal xiphoid process morphology J:122320
cleft palate J:122320
perinatal lethality, complete penetrance J:122320
thick epidermis J:122320
Chuktm1Aki/Chuktm1Aki
involves: 129P2/OlaHsd 		abnormal craniofacial bone morphology J:54315
abnormal epidermis stratum basale morphology J:54315
abnormal epidermis stratum corneum morphology J:54315
abnormal epidermis stratum spinosum morphology J:54315
abnormal epidermis suprabasal layer morphology J:54315
abnormal hair follicle development J:54315
abnormal keratinocyte differentiation J:54315
abnormal limb bud morphology J:54315
abnormal limb morphology J:54315
absent epidermis stratum granulosum J:54315
normal cellular phenotype J:54315
epidermal hyperplasia J:54315
impaired skin barrier function J:54315
neonatal lethality, complete penetrance J:54315
parakeratosis J:54315
shiny skin J:54315
short limbs J:54315
short snout J:54315
short tail J:54315
shortened head J:54315
small cranium J:54315
thick epidermis J:54315
tight skin J:54315
Chuktm1Lex/Chuktm1Lex
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129S/Sv * 129S/SvEvBrd * C57BL/6 		abnormal fibroblast migration J:159873
decreased fibroblast cell migration J:159873
decreased fibroblast chemotaxis J:159873
Chuktm1Lex/Chuktm1Lex
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S/SvEvBrd 		impaired macrophage chemotaxis J:159873
impaired neutrophil chemotaxis J:159873
impaired neutrophil recruitment J:159873
Chuktm1Mka/Chuktm1Mka
B6.129-Chuktm1Mka 		abnormal B cell physiology J:113556
Chuktm1Mka/Chuktm1Mka
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial development J:184926
Chuktm1Mka/Chuktm1Mka
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA 		abnormal anterior eye segment morphology J:65553
abnormal apical ectodermal ridge morphology J:54316
abnormal chondrocyte differentiation J:54316
abnormal conjunctiva morphology J:65553
abnormal corneal stroma morphology J:65553
abnormal cranium morphology J:54316
abnormal enamel knot morphology J:90053
abnormal epidermis stratum spinosum morphology J:54316
abnormal epidermis suprabasal layer morphology J:54316
abnormal eyelid morphology J:65553
abnormal incisor morphology J:90053
abnormal keratinocyte differentiation J:54316
abnormal limb morphology J:54316
abnormal molar cusp morphology J:90053
abnormal nasal capsule morphology J:54316
abnormal phalanx morphology J:54316
abnormal placenta vasculature J:54316
abnormal presphenoid bone morphology J:54316
abnormal sacral vertebrae morphology J:54316
abnormal skin morphology J:54316
abnormal skin physiology J:54316
abnormal tail morphology J:54316
abnormal vibrissa follicle morphology J:90053
abnormal zygomatic bone morphology J:54316
absent epidermis stratum corneum J:54316
absent epidermis stratum granulosum J:54316
anotia J:54316
brachydactyly J:54316
normal cellular phenotype J:54316
cervical vertebral fusion J:54316
decreased birth body size J:54316
decreased bone mineralization J:54316
decreased cranium height J:54316
delayed bone ossification J:54316
disorganized corneal epithelium J:65553
epidermal hyperplasia J:54316
esophageal atresia J:54316
eyelids open at birth J:65553
interdigital webbing J:54316
neonatal lethality, complete penetrance J:54316
omphalocele J:54316
sacral vertebral fusion J:54316
short forelimb J:54316
short mandible J:54316
short snout J:54316
short sternum J:54316
short vertebral column J:54316
shortened head J:54316
small cranium J:54316
small interparietal bone J:54316
small nasal septum J:54316
small parietal bone J:54316
small sacral vertebrae J:54316
small thoracic cage J:54316
small vomer bone J:54316
split xiphoid process J:54316
syndactyly J:54316
thick epidermis J:54316
thick skin J:54316
tight skin J:54316
wide frontal bone J:54316
Chuktm1Mpa/Chuktm1Mpa
Tg(KRT14-cre)1Cgn/?
involves: C57BL/6 		abnormal epidermis stratum corneum morphology J:122320
abnormal keratinocyte differentiation J:122320
abnormal skin condition J:122320
abnormal skin morphology J:122320
decreased circulating free fatty acids level J:122320
impaired skin barrier function J:122320
increased cholesterol level J:122320
neonatal lethality, complete penetrance J:122320
shiny skin J:122320
normal skeleton phenotype J:122320
weight loss J:122320
Chuktm1Ver/Chuktm1Ver
involves: 129S4/SvJae * C57BL/6J 		abnormal cell physiology J:55415
abnormal craniofacial bone morphology J:55415
abnormal embryonic tissue morphology J:55415
abnormal epidermal layer morphology J:55415
abnormal epidermis stratum granulosum morphology J:55415
abnormal epidermis suprabasal layer morphology J:55415
abnormal hair follicle morphology J:55415
abnormal hindlimb morphology J:55415
abnormal incisor morphology J:55415
abnormal intestine morphology J:55415
abnormal keratinocyte differentiation J:55415
abnormal limb bud morphology J:55415
abnormal limb morphology J:55415
abnormal phalanx morphology J:55415
abnormal skin appearance J:55415
abnormal sternebra morphology J:55415
abnormal sternum ossification J:55415
absent epidermis stratum corneum J:55415
absent vibrissae J:55415
asymmetric sternocostal joints J:55415
cleft secondary palate J:55415
curly tail J:55415
dilated gallbladder J:55415
epidermal desquamation J:55415
impaired skin barrier function J:55415
neonatal lethality, complete penetrance J:55415
omphalocele J:55415
palatal shelves fail to meet at midline J:55415
shiny skin J:55415
short limbs J:55415
small incisors J:55415
small stomach J:55415
thick skin J:55415
translucent skin J:55415
wide sternum J:55415
Chuktm1Yhu/Chuktm1Yhu
Tg(Krt1-5-cre/ERT)1Ipc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		epidermal hyperplasia J:141162
increased skin tumor incidence J:141162
Chuktm1Yhu/Chuktm1Yhu
Tg(Krt1-15-cre/PGR*)22Cot/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased carcinoma incidence J:141162
increased skin papilloma incidence J:141162
increased skin tumor incidence J:141162
Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0
B6.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj 		postnatal lethality, complete penetrance J:141162
thick skin J:141162
Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0
FVB.Cg-Chuktm1Yhu Tg(KRT5-cre)5132Jlj 		postnatal lethality, complete penetrance J:141162
thick skin J:141162
Chuktm1Yhu/Chuktm1Yhu
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal keratinocyte differentiation J:141162
abnormal skeleton morphology J:141162
abnormal skin morphology J:141162
epidermal hyperplasia J:141162
increased keratinocyte proliferation J:141162
postnatal growth retardation J:141162
postnatal lethality, complete penetrance J:141162
small esophagus J:141162
thick epidermis J:141162
thick skin J:141162
wrinkled skin J:141162
Chuktm1Yhu/Chuktm1Yhu
Tg(KRT14-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal skin morphology J:141162
epidermal hyperplasia J:141162
Chuktm1Yhu/Chuktm1Yhu
Tg(MMTV-cre)4Mam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB 		epidermal hyperplasia J:141162
increased skin tumor incidence J:141162
sparse hair J:141162
Chuktm2Mka/Chuktm2Mka
B6.Cg-Chuktm2Mka 		abnormal B cell physiology J:113556
Chuktm2Mka/Chuktm2Mka
Not Specified 		abnormal lactation J:90978
abnormal mammary gland alveolus morphology J:90978
abnormal mammary gland epithelium morphology J:90978
abnormal mammary gland growth during pregnancy J:90978
Chuktm2Yhu/Chuktm2Yhu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		esophagus hyperplasia J:197037
increased keratinocyte proliferation J:197037
increased skin squamous cell carcinoma incidence J:197037
Chuktm2Yhu/Chuktm2Yhu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		normal integument phenotype J:201799
Chuktm2Yhu/Chuktm2Yhu
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		increased lung tumor incidence J:197037
premature death J:197037
skin inflammation J:197037
skin lesions J:197037
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory