Chuk^tm1Mka
Targeted Allele Detail

Summary

• Symbol: Chuk^tm1Mka
• Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Michael Karin
• MGI ID: MGI:1857768
• Synonyms: Ikka-, Ikkalpha^-
• Gene: Chuk Location: Chr19:44061774-44095919 bp, - strand Genetic Position: Chr19, 36.71 cM
• Alliance: Chuk^tm1Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54316
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ gene and neomycin cassette replaced part of the exon that encodes the ATP binding site (amino acids 192-212). Western blot analysis on extracts of E18 embryos did not detect expression of protein expressed from this allele in homozygous mice. (J:54316)

Disease models

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	37 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chuk Mutation: 48 strains or lines available

References

• Original: J:54316 Hu Y, et al., Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase [see comments]. Science. 1999 Apr 9;284(5412):316-20
• All: 22 reference(s)