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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nf1
neurofibromin 1
MGI:97306
97 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cdkn2atm1Rdp/\Cdkn2a+
\Nf1tm1Tyj/\Nf1+
involves: 129S2/SvPas * 129S6/SvEvTac 		increased neurofibrosarcoma incidence J:131914
\Cdkn2atm1Rdp/\Cdkn2atm1Rdp
\Nf1tm1Tyj/\Nf1+
involves: 129S2/SvPas * 129S6/SvEvTac 		increased leukemia incidence J:131914
increased lymphoma incidence J:131914
increased neurofibrosarcoma incidence J:131914
normal nervous system phenotype J:131914
premature death J:131914
\Cdkn2atm2.1Rdp/\Cdkn2atm2.1Rdp
\Nf1tm1Tyj/\Nf1+
involves: 129S2/SvPas * 129S6/SvEvTac 		increased lymphoma incidence J:131914
normal neoplasm J:131914
\Cdkn2atm4Rdp/\Cdkn2atm4Rdp
\Nf1tm1Par/\Nf1tm1Par
involves: 129S1/Sv * 129X1/SvJ 		increased neurofibrosarcoma incidence J:234760
increased rhabdomyosarcoma incidence J:234760
increased sarcoma incidence J:234760
\Cpt1cGt(XL823)Byg/\Cpt1c+
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		decreased metastatic potential J:228258
decreased sarcoma incidence J:228258
spleen hyperplasia J:228258
\Egfrwa2/\Egfr+
\Nf1tm1Fcr/\Nf1+
\Trp53tm1Brd/\Trp53+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * C57BL/6JEi * C3H/HeSnJ 		decreased tumor incidence J:95933
\Grin1tm1Stl/\Grin1+
\Nf1tm1Tyj/\Nf1+
involves: 129S2/SvPas * C57BL/6J 		abnormal spatial learning J:38703
\Gt(ROSA)26Sortm1Fia/\Gt(ROSA)26Sor+
\Nf1tm1Fcr/\Nf1tm1Par
\Tg(Tek-cre)1Ywa/0
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal dorsal root ganglion morphology J:114455
abnormal spleen morphology J:114455
prenatal lethality, complete penetrance J:114455
\Gt(ROSA)26Sortm1Fia/\Gt(ROSA)26Sor+
\Nf1tm1Par/\Nf1tm1Par
\Tg(Fabp7-cre,-lacZ)3Gtm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		decreased body weight J:138868
decreased circulating growth hormone level J:138868
small adenohypophysis J:138868
\Gt(ROSA)26Sortm1Fia/\Gt(ROSA)26Sor+
\Hprt1tm1(CMV-cre)Brd/\Hprt1+
\Nf1tm1Fcr/\Nf1tm1Fcr
involves: 129S/SvEv * 129S/SvEvBrd 		abnormal dorsal root ganglion morphology J:114455
abnormal enzyme/coenzyme level J:114455
abnormal somatic sensory system morphology J:114455
abnormal sympathetic ganglion morphology J:114455
adrenal medulla hyperplasia J:114455
prenatal lethality, incomplete penetrance J:114455
\Gt(ROSA)26Sortm1Fia/\Gt(ROSA)26Sortm1Fia
\Hprt1tm1(CMV-cre)Brd/\Hprt1+
\Nf1tm1Fcr/\Nf1tm1Fcr
involves: 129S/SvEv * 129S/SvEvBrd 		abnormal somatic sensory system morphology J:114455
\Lrrc17tm1Nik/\Lrrc17+
\Nf1tm1Par/\Nf1tm1Par
\Srpk2tm1Nik/\Srpk2+
\Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		increased leukocyte cell number J:161558
premature death J:161558
\Nf1tm1Fcr/\Nf1+
\Trp53tm1Tyj/\Trp53+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		increased carcinoma incidence J:58877
increased fibrohistocytoma incidence J:58877
increased leiomyosarcoma incidence J:58877
increased lymphoma incidence J:58877
increased malignant triton tumor incidence J:58877
increased neuroblastoma incidence J:58877
increased neurofibrosarcoma incidence J:58877
increased rhabdomyosarcoma incidence J:58877
increased sarcoma incidence J:58877
premature death J:58877
\Nf1tm1Fcr/\Nf1+
\Trp53tm1Tyj/\Trp53tm1Tyj
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		increased lymphoma incidence J:58877
postnatal lethality, incomplete penetrance J:58877
\Nf1tm1Fcr/\Nf1+
\Trp53tm1Brd/\Trp53+
B6.129-Trp53tm1Brd Nf1tm1Fcr 		decreased tumor-free survival time J:95933
increased brain tumor incidence J:95933
increased malignant tumor incidence J:95933
increased sarcoma incidence J:95933
\Nf1tm1Fcr/\Nf1+
\Ptentm1Hwu/\Ptentm1Hwu
\Tg(Mx1-cre)1Cgn/0
B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu 		abnormal bone marrow morphology J:232645
abnormal hematopoietic stem cell morphology J:232645
abnormal hemopoiesis J:232645
abnormal liver morphology J:232645
abnormal lung morphology J:232645
abnormal spleen morphology J:232645
anemia J:232645
decreased B cell number J:232645
decreased bone marrow cell number J:232645
decreased hemoglobin content J:232645
decreased lymphocyte cell number J:232645
decreased T cell number J:232645
enlarged liver J:232645
enlarged spleen J:232645
increased granulocyte number J:232645
increased leukocyte cell number J:232645
increased liver weight J:232645
increased macrophage cell number J:232645
increased monocyte cell number J:232645
increased spleen weight J:232645
increased T cell acute lymphoblastic leukemia incidence J:232645
increased tumor incidence J:232645
premature death J:232645
thrombocytosis J:232645
\Nf1tm1Fcr/\Nf1+
\Tsc1tm1Djk/\Tsc1tm1Djk
\Tg(GFAP-cre)#Gtm/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA 		normal neoplasm J:176586
premature death J:176586
\Nf1tm1Fcr/\Nf1+
\Tg(Cnp-EGFR)10Nrat/0
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal nervous system morphology J:95933
abnormal somatic nervous system morphology J:95933
decreased tumor incidence J:95933
\Nf1tm1Fcr/\Nf1tm1Fcr
\Trp53tm1Elee/\Trp53tm1Elee
\Tg(GFAP-cre)25Mes/0
involves: 129S/SvEv * 129S4/SvJae * FVB/N 		decreased tumor latency J:149662
increased glioma incidence J:149662
premature death J:149662
\Nf1tm1Par/\Nf1+
\Trp53tm1Tyj/\Trp53+
\Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N 		increased astrocytoma incidence J:134611
increased brain tumor incidence J:134611
premature death J:134611
\Nf1tm1Par/\Nf1+
\Ptentm1Hwu/\Pten+
\Trp53tm1Tyj/\Trp53+
\Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N 		ataxia J:134611
increased astrocytoma incidence J:134611
increased brain tumor incidence J:134611
increased startle reflex J:134611
premature death J:134611
seizures J:134611
unidirectional circling J:134611
\Nf1tm1Par/\Nf1+
\Ptentm1Hwu/\Pten+
\Trp53tm1Elee/\Trp53+
\Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N 		ataxia J:134611
increased astrocytoma incidence J:134611
increased brain tumor incidence J:134611
increased startle reflex J:134611
premature death J:134611
seizures J:134611
unidirectional circling J:134611
\Nf1tm1Par/\Nf1+
\Ptentm1Hwu/\Pten+
\Tg(Gfap-cre)77.6Mvs/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6NHsd 		normal neoplasm J:154673
\Nf1tm1Par/\Nf1+
\Trp53tm1Elee/\Trp53+
\Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N 		ataxia J:134611
increased astrocytoma incidence J:134611
increased brain tumor incidence J:134611
increased startle reflex J:134611
premature death J:134611
seizures J:134611
unidirectional circling J:134611
\Nf1tm1Par/\Nf1tm1Par
\Rnf7Gt(XE423)Byg/\Rnf7Gt(XE423)Byg
involves: 129 * C57BL/6 		abnormal angiogenesis J:178926
decreased cell proliferation J:178926
embryonic growth retardation J:178926
increased apoptosis J:178926
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
(C3H/HeJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 		ataxia J:64364
decreased tumor-free survival time J:64364
increased astrocytoma incidence J:64364
increased brain tumor incidence J:64364
increased glioblastoma incidence J:64364
paralysis J:64364
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
(CAST/EiJ x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 		ataxia J:64364
decreased tumor-free survival time J:64364
increased astrocytoma incidence J:64364
increased brain tumor incidence J:64364
increased glioblastoma incidence J:64364
paralysis J:64364
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
(CBA/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 		increased brain tumor incidence J:64364
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
(SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1 		ataxia J:64364
decreased tumor-free survival time J:64364
increased astrocytoma incidence J:64364
increased brain tumor incidence J:64364
increased glioblastoma incidence J:64364
paralysis J:64364
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ + 		ataxia J:64364
decreased tumor-free survival time J:64364
increased astrocytoma incidence J:64364
increased brain tumor incidence J:64364
increased glioblastoma incidence J:64364
paralysis J:64364
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
involves: 129/Sv * C57BL/6 		increased neurofibrosarcoma incidence J:58876
increased sarcoma incidence J:58876
increased tumor incidence J:58876
premature death J:58876
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
involves: 129S2/SvPas 		increased neurofibrosarcoma incidence J:131914
normal nervous system phenotype J:131914
\Nf1tm1Tyj/\Nf1+
\Trp53tm1Tyj/\Trp53+
involves: 129S2/SvPas * C57BL/6 		increased glioma incidence J:217077
increased histiocytic sarcoma incidence J:217077
increased lymphoma incidence J:217077, J:228258
increased metastatic potential J:228258
increased neuroblastoma incidence J:217077
increased neurofibrosarcoma incidence J:217077
increased sarcoma incidence J:228258
increased tumor incidence J:217077
premature death J:217077, J:228258
spleen hyperplasia J:228258
\Nf1tm1Tyj/\Nf1+
\Tg(Th-MYCN)41Waw/0
involves: 129S2/SvPas * BALB/c * C57BL/6J 		increased neuroblastoma incidence J:41126
\Nf1tm1Tyj/\Nf1+
\Suz12Gt(Betageo)1Khe/\Suz12+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal melanocyte morphology J:217077
increased hepatocellular carcinoma incidence J:217077
increased histiocytic sarcoma incidence J:217077
increased intestinal adenoma incidence J:217077
increased lymphoma incidence J:217077
increased neurofibroma incidence J:217077
increased neurofibrosarcoma incidence J:217077
increased Schwannoma incidence J:217077
increased tumor incidence J:217077
premature death J:217077
\Nf1tm1Tyj/\Nf1+
\Suz12Gt(Betageo)1Khe/\Suz12+
\Trp53tm1Tyj/\Trp53+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		increased glioma incidence J:217077
increased hemangiosarcoma incidence J:217077
increased histiocytic sarcoma incidence J:217077
increased lymphoma incidence J:217077
increased neurofibrosarcoma incidence J:217077
increased tumor incidence J:217077
premature death J:217077
\Nf1tm1Tyj/\Nf1+
\Pak1tm1Cher/\Pak1tm1Cher
involves: 129S2/SvPas * C57BL/6 		abnormal mast cell physiology J:142439
\Nf1tm1Tyj/\Nf1tm1Tyj
\Rasa1tm1Paw/\Rasa1tm1Paw
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) 		abnormal brain morphology J:29825
abnormal embryo turning J:29825
abnormal embryonic tissue morphology J:29825
abnormal extraembryonic tissue morphology J:29825
abnormal heart morphology J:29825
abnormal hindbrain morphology J:29825
abnormal neural tube morphology J:29825
abnormal pharyngeal arch morphology J:29825
absent forebrain J:29825
absent limb buds J:29825
absent midbrain J:29825
absent otic vesicle J:29825
embryonic growth arrest J:29825
enlarged allantois J:29825
excessive folding of visceral yolk sac J:29825
failure of somite differentiation J:29825
increased cranial neural crest cell apoptosis J:29825
increased hindbrain apoptosis J:29825
\Nf1tm1Tyj/?
\Nstr1A/J/?
\Trp53tm1Tyj/?
involves: 129S2/SvPas * A/J * C57BL/6J 		decreased tumor incidence J:105038
\Nf1tm1Tyj/?
\Nstr1C57BL/6J/\Nstr1C57BL/6J
\Trp53tm1Tyj/?
involves: 129S2/SvPas * A/J * C57BL/6J 		increased neurofibrosarcoma incidence J:105038
\Nf1tm1Tyj/?
\Nstr2A/J/?
\Trp53tm1Tyj/?
involves: 129S2/SvPas * A/J * C57BL/6J 		decreased tumor incidence J:105038
\Nf1tm1Tyj/?
\Trp53tm1Tyj/?
\Mastr129S4/SvJae/?
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J 		decreased tumor incidence J:92444
\Nf1tm1Tyj/?
\Trp53tm1Tyj/?
\MastrC57BL/6J/?
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J 		increased astrocytoma incidence J:92444
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory