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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smad4
SMAD family member 4
MGI:894293
55 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apctm1Mmt/Apc+
Smad4tm1Mmt/Smad4+
involves: 129S2/SvPas * C57BL/6 		epidermal cyst J:46242
increased intestinal adenocarcinoma incidence J:46242
increased pancreatic ductal adenocarcinoma incidence J:46242
premature death J:46242
Apctm1Mmt/Apc+
Mmp7tm1Lmm/Mmp7tm1Lmm
Smad4tm1Mmt/Smad4+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		decreased tumor growth/size J:142797
decreased tumor incidence J:142797
Apctm1Rak/Apc+
Smad4E6sad/Smad4+
B6.129P2-Apctm1Rak +/+ Smad4E6sad 		gastric polyps J:107273
increased intestinal adenocarcinoma incidence J:107273
increased intestinal adenoma incidence J:107273
premature death J:107273
Apctm1Rak/Apc+
Smad4E6sad/Smad4+
B6.129P2-Apctm1Rak Smad4E6sad/+ + 		anemia J:107273
enlarged spleen J:107273
gastric polyps J:107273
increased intestinal adenoma incidence J:107273
intestine polyps J:107273
premature death J:107273
Apctm2Rfo/Apc+
Smad4E6sad/Smad4+
involves: 129P2/OlaHsd * C57BL/6J 		increased gastrointestinal tumor incidence J:151494
increased mammary adenocarcinoma incidence J:151494
Cdh1tm2Kem/Cdh1+
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)7Mul/0
involves: 129 * C57BL/6 * FVB/N 		increased mammary adenocarcinoma incidence J:212549
increased metastatic potential J:212549
Cdh1tm2Kem/Cdh1+
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(Pdx1-cre)6Tuv/0
involves: 129 * C57BL/6 * FVB/N 		increased duodenum adenocarcinoma incidence J:212549
increased gastric adenocarcinoma incidence J:212549
increased metastatic potential J:212549
increased squamous cell carcinoma incidence J:212549
premature death J:212549
Cdh1tm2Kem/Cdh1+
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(Vil1-cre)20Syr/0
involves: 129 * C57BL/6 * DBA/2 		increased intestinal adenocarcinoma incidence J:212549
Cdh1tm2Kem/Cdh1tm2Kem
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(Pdx1-cre)6Tuv/0
involves: 129 * C57BL/6 * FVB/N 		increased gastric adenocarcinoma incidence J:212549
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
increased tumor incidence J:116130
Cdkn2atm4Rdp/Cdkn2a+
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
increased stomach tumor incidence J:116130
increased tumor incidence J:116130
Cdkn2atm4Rdp/Cdkn2a+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N 		normal neoplasm J:116130
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
increased stomach tumor incidence J:116130
increased tumor incidence J:116130
Krastm4Tyj/Kras+
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Krt1-15-cre/PGR*)22Cot/0
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J 		increased adenoma incidence J:203922
increased metastatic potential J:203922
increased papilloma incidence J:203922
increased skin squamous cell carcinoma incidence J:203922
increased skin tumor incidence J:203922
increased trichoepithelioma incidence J:203922
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * FVB/N 		decreased tumor-free survival time J:116130
increased pancreatic ductal adenocarcinoma incidence J:116130
increased tumor incidence J:116130
pancreas cyst J:116130
Krastm4Tyj/Kras+
Smad4tm1Rdp/Smad4tm1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA * FVB/N 		decreased tumor-free survival time J:116130
increased stomach tumor incidence J:116130
increased tumor incidence J:116130
pancreas cyst J:116130
Ptentm1Hwu/Ptentm1Hwu
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Alb1-cre)1Dlr/0
involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N 		abnormal bile duct morphology J:111718
enlarged liver J:111718
hepatic steatosis J:111718
increased cholangiocarcinoma incidence J:111718
increased liver weight J:111718
premature death J:111718
Ptentm1Rdp/Ptentm1Rdp
Smad4tm1Rdp/Smad4tm1Rdp
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
involves: 129 * C57BL/6 * DBA/2 		increased metastatic potential J:186105
increased prostate gland adenocarcinoma incidence J:186105
premature death J:186105
Ptentm2Mak/Ptentm2Mak
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(KRT5-cre)1Xya/0
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal hair follicle regression J:101602
alopecia J:101602
decreased tumor latency J:101602
epithelioid cyst J:101602
increased carcinoma incidence J:101602
increased hair follicle cell proliferation J:101602
increased keratinocyte proliferation J:101602
increased skin papilloma incidence J:101602
increased skin tumor incidence J:101602
increased stomach tumor incidence J:101602
premature death J:101602
thick epidermis J:101602
thick hair follicle outer root sheath J:101602
Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal pancreas morphology J:229184
abnormal pancreatic acinar cell morphology J:229184
abnormal pancreatic duct morphology J:229184
abnormal pancreatic islet morphology J:229184
chronic pancreas inflammation J:229184
dilated pancreatic duct J:229184
enlarged pancreas J:229184
increased pancreatic intraepithelial neoplasia incidence J:229184
pancreas cyst J:229184
pancreas fibrosis J:229184
pancreatic acinar-to-ductal metaplasia J:229184
Smad4tm1Rdp/Smad4tm1.1Rdp
Trim33tm1.1Los/Trim33tm1.2Los
Tg(CAG-cre)13Miya/0
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * SJL 		abnormal embryo development J:163858
absent anterior visceral endoderm J:163858
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)7Mul/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N 		increased mammary adenocarcinoma incidence J:212549
increased metastatic potential J:212549
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N 		normal neoplasm J:212549
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(Vil1-cre)20Syr/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 		increased intestinal adenocarcinoma incidence J:212549
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory