Mmp7^tm1Lmm
Targeted Allele Detail

Summary

• Symbol: Mmp7^tm1Lmm
• Name: matrix metallopeptidase 7; targeted mutation 1, Lynn M Matrisian
• MGI ID: MGI:1857932
• Synonyms: MAT-, mmp-7^-, mmp7^-, MMP7^-, Mmp7^tm1vu
• Gene: Mmp7 Location: Chr9:7692091-7699586 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Mmp7^tm1Lmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38609
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced approximately 95 nucleotides of coding sequence in exon 4 of the gene. No transcript for the targeted gene was detectable by Northern blot analysis of RNA from the small intestine of homozygous mutant mice. (J:38609)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mmp7^tm1Lmm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mmp7 Mutation: 21 strains or lines available

References

• Original: J:38609 Wilson CL, et al., Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1402-7
• All: 53 reference(s)