48 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Adam10Pied/Adam10+ Cd44tm1Hbg/Cd44tm1Hbg Hrhr/Hrhr involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl	abnormal skin pigmentation	J:262499
	hairless	J:262499
ApcMin/Apc+ Cd44tm1Mak/Cd44tm1Mak involves: 129P2/OlaHsd * C57BL/6J	decreased intestinal adenoma incidence	J:135025
	increased small intestinal crypt cell apoptosis	J:135025
ApcMin/Apc+ Cd44tm1Mak/Cd44tm1Mak involves: C57BL/6J	decreased intestinal adenoma incidence	J:204874
	increased enterocyte apoptosis	J:204874
	increased tumor-free survival time	J:204874
ApcMin/Apc+ Cd44tm1Stpa/Cd44tm1Stpa involves: C57BL/6J * C57BL/6JIco	increased intestinal adenoma incidence	J:204874
	premature death	J:204874
ApcMin/Apc+ Cd44tm1Stpa/Cd44tm2Stpa involves: C57BL/6J	increased intestinal adenoma incidence	J:204874
ApcMin/Apc+ Cd44tm2Stpa/Cd44tm2Stpa involves: C57BL/6J	decreased intestinal adenoma incidence	J:204874
	increased tumor-free survival time	J:204874
Apoetm1Unc/Apoetm1Unc Cd44tm1Mak/Cd44+ B6.129P2-Cd44tm1Mak Apoetm1Unc	decreased susceptibility to atherosclerosis	J:72315
Apoetm1Unc/Apoetm1Unc Cd44tm1Mak/Cd44tm1Mak B6.129P2-Cd44tm1Mak Apoetm1Unc	decreased susceptibility to atherosclerosis	J:72315
Cd44tm1.1Ugu/Cd44tm1.1Ugu Il10tm1Cgn/Il10tm1Cgn involves: 129/Sv * C57BL/6	abnormal immune system physiology	J:62867
	weight loss	J:62867
Cd44tm1Hbg/Cd44+ Tnftm2Gkl/Tnf+ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	ileum inflammation	J:145626
Cd44tm1Hbg/Cd44tm1Hbg Tg(TNF)197Gkl/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal articular cartilage morphology	J:97992
	abnormal osteoclast differentiation	J:97992
	abnormal osteoclast morphology	J:97992
	arthritis	J:97992
	decreased body weight	J:97992
	decreased bone mass	J:97992
	decreased compact bone thickness	J:97992
	decreased grip strength	J:97992
	decreased trabecular bone mass	J:97992
	decreased trabecular bone volume	J:97992
	increased bone resorption	J:97992
	increased circulating interleukin-1 level	J:97992
	increased circulating interleukin-6 level	J:97992
	increased interleukin-1 secretion	J:97992
	increased interleukin-6 secretion	J:97992
	increased osteoclast cell number	J:97992
	joint swelling	J:97992
Cd44tm1Hbg/Cd44tm1Hbg Tnftm2Gkl/Tnf+ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	normal digestive/alimentary phenotype	J:145626
	normal immune system phenotype	J:145626
Cd44tm1Mak/Cd44tm1Mak Gab1tm1Wbm/Gab1+ involves: 129P2/OlaHsd * C57BL/6	lethality, incomplete penetrance	J:128984
	neonatal lethality, incomplete penetrance	J:128984
Cd44tm1Mak/Cd44tm1Mak Hgftm1Kita/Hgf+ involves: 129S4/SvJae * C57BL/6	neonatal lethality, incomplete penetrance	J:128984
Cd44tm1Mak/Cd44tm1Mak Itgaltm1Mak/Itgaltm1Mak B6.129P2-Cd44tm1Mak Itgaltm1Mak	impaired natural killer cell mediated cytotoxicity	J:110889
Cd44tm1Mak/Cd44tm1Mak Mettm1Cbm/Met+ involves: 129P2/OlaHsd * C57BL/6	abnormal miniature excitatory postsynaptic currents	J:128984
	abnormal miniature inhibitory postsynaptic currents	J:128984
	abnormal phrenic nerve morphology	J:128984
	decreased miniature inhibitory postsynaptic current frequency	J:128984
	lethality, incomplete penetrance	J:128984
	neonatal lethality, incomplete penetrance	J:128984
	primary atelectasis	J:128984
	respiratory distress	J:128984
Cd44tm1Mak/Cd44tm1Mak Tg(MMTV-PyVT)634Mul/0 B6.Cg-Cd44tm1Mak Tg(MMTV-PyVT)634Mul	increased metastatic potential	J:100774
Cd44tm1Mak/Cd44tm1Mak Tg(MMTV-PyVT)634Mul/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	increased metastatic potential	J:100774
Cd44tm1Mak/Cd44tm1Mak Trp53tm1Tyj/Trp53+ involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J	decreased metastatic potential	J:76201
	increased lymphoma incidence	J:76201
Cd44tm2Kmz/Cd44tm2Kmz Selltm2Hyn/Selltm2Hyn involves: 129S2/SvPas * BALB/c * DBA/1	abnormal CD4-positive, alpha-beta T cell physiology	J:114317
	abnormal leukocyte adhesion	J:114317
	decreased susceptibility to type IV hypersensitivity reaction	J:114317
	impaired leukocyte tethering or rolling	J:114317
	impaired neutrophil recruitment	J:114317