Met^tm1Cbm
Targeted Allele Detail

Summary

• Symbol: Met^tm1Cbm
• Name: met proto-oncogene; targeted mutation 1, Carmen Birchmeier
• MGI ID: MGI:1857655
• Synonyms: c-Met -, met^-
• Gene: Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
• Alliance: Met^tm1Cbm page

Cleft palate in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm, Gab1^tm1Wbm/Gab1^tm1Wbm and Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺ mice, but not in Gab1^tm4Wbm/Gab1^tm4Wbm mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28570
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced an exon encoding the invariant lysine 1108. RNAse protection analysis revealed that normal levels of a transcript lacking nucleotides 3254-3334 is produced from this allele, but no protein activity is detectable in an in vitro auto-kinase assay. (J:28570)

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Met Mutation: 82 strains or lines available

References

• Original: J:28570 Bladt F, et al., Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud [see comments]. Nature. 1995 Aug 31;376(6543):768-71
• All: 10 reference(s)