84 phenotypes from 9 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
En1tm2(cre)Wrst/En1+ Mfn2tm1Dcc/Mfn2tm3Dcc involves: 129 * 129S4/SvJaeSor * Black Swiss	abnormal neuron mitochondrial morphology	J:132329
	abnormal Purkinje cell dendrite morphology	J:132329
	decreased body size	J:132329
	impaired limb coordination	J:132329
	impaired righting response	J:132329
	increased neuron apoptosis	J:132329
	postnatal lethality, complete penetrance	J:132329
	Purkinje cell degeneration	J:132329
	small cerebellum	J:132329
Gabra6tm2(cre)Wwis/Gabra6+ Mfn2tm1Dcc/Mfn2tm3Dcc involves: 129 * 129S4/SvJaeSor * Black Swiss	no abnormal phenotype detected	J:132329
Meox2tm1(cre)Sor/Meox2+ Mfn2tm1Dcc/Mfn2tm3Dcc involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	decreased body size	J:132329
	impaired limb coordination	J:132329
	impaired righting response	J:132329
	neonatal lethality, incomplete penetrance	J:132329
	postnatal lethality, complete penetrance	J:132329
	small cerebellum	J:132329
Mfn2em1Cya/Mfn2em1Cya Tg(Stra8-icre)1Reb/0 involves: C57BL/6J * FVB/NJ	abnormal male meiosis	J:324164
	abnormal sperm mitochondrial sheath morphology	J:324164
	abnormal sperm nucleus morphology	J:324164
	kinked sperm flagellum	J:324164
	small seminiferous tubules	J:324164
	small testis	J:324164
Mfn2tm1.1Arte/Mfn2tm1.1Arte Slc6a3tm1(cre)Lrsn/Slc6a3+ involves: 129S1/Sv * 129X1/SvJ	abnormal innervation	J:188337
	abnormal locomotor activation	J:188337
	abnormal neuron physiology	J:188337
	abnormal respiratory electron transport chain	J:188337
	abnormal substantia nigra pars compacta morphology	J:188337
	decreased body weight	J:188337
	decreased dopamine level	J:188337
	decreased locomotor activity	J:188337
	decreased vertical activity	J:188337
	increased serotonin level	J:188337
	premature death	J:188337
	weight loss	J:188337
Mfn2tm1.1Balo/Mfn2tm1.1Balo Not Specified	abnormal axonal transport	J:159219
	abnormal mitochondrial physiology	J:159219
	lethality throughout fetal growth and development, complete penetrance	J:159219
Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal mitochondrial morphology	J:188865
Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe Myl2tm1(cre)Krc/Myl2+ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J	abnormal autophagy	J:188865
	abnormal cellular respiration	J:188865
	abnormal mitochondrial morphology	J:188865
	abnormal myocardial fiber morphology	J:188865
	abnormal myocardial fiber physiology	J:188865
	decreased ventricle muscle contractility	J:188865
	increased fetal cardiomyocyte apoptosis	J:188865
	increased response of heart to induced stress	J:188865
	lipofuscinosis	J:188865
Mfn2tm1b(EUCOMM)Wtsi/Mfn2+ C57BL/6N-Mfn2tm1b(EUCOMM)Wtsi/Ieg	abnormal gait	J:211773
	decreased lean body mass	J:211773
Mfn2tm1b(EUCOMM)Wtsi/Mfn2tm1b(EUCOMM)Wtsi C57BL/6N-Mfn2tm1b(EUCOMM)Wtsi/Ieg	preweaning lethality, complete penetrance	J:211773
Mfn2tm1Dcc/Mfn2tm1Dcc involves: 129S/SvEv	abnormal mitochondrial morphology	J:81438
	abnormal mitochondrial physiology	J:81438
	abnormal trophoblast layer morphology	J:81438
	decreased embryo size	J:81438
	decreased trophoblast giant cell number	J:81438
	embryonic lethality during organogenesis, incomplete penetrance	J:81438
Mfn2tm1Dcc/Mfn2tm3Dcc involves: 129 * 129S4/SvJaeSor * Black Swiss	abnormal mitochondrial morphology	J:132329
Mfn2tm1Dcc/Mfn2tm3Dcc H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129 * 129S4/SvJaeSor * Black Swiss	decreased body size	J:132329
	impaired limb coordination	J:132329
	impaired righting response	J:132329
	postnatal lethality, complete penetrance	J:132329
	small cerebellum	J:132329
Mfn2tm1Dcc/Mfn2tm3Dcc Tg(EIIa-cre)C5379Lmgd/0 involves: 129 * 129S4/SvJaeSor * Black Swiss * FVB/N	prenatal lethality, complete penetrance	J:132329
Mfn2tm1Dcc/Mfn2tm3Dcc Tg(Pcp2-cre)2Mpin/0 involves: 129 * 129S4/SvJaeSor * Black Swiss	abnormal axon morphology	J:132329
	abnormal cerebellum morphology	J:132329
	abnormal gait	J:132329
	abnormal neuron mitochondrial morphology	J:132329
	abnormal Purkinje cell dendrite morphology	J:132329
	abnormal respiratory electron transport chain	J:132329
	impaired coordination	J:132329
	Purkinje cell degeneration	J:132329
	small cerebellum	J:132329
Mfn2tm2Dcc/Mfn2tm2Dcc involves: 129S/SvEv	abnormal axonal transport	J:159219
	abnormal mitochondrial physiology	J:159219
Mfn2tm2Dcc/Mfn2tm2Dcc involves: 129S/SvEv * FVB/N	abnormal mitochondrial morphology	J:119702
Mfn2tm3Dcc/Mfn2tm3Dcc Tg(Stra8-icre)1Reb/0 involves: 129 * C57BL/6J * FVB/NJ	abnormal endoplasmic reticulum morphology	J:305430
	abnormal male germ cell morphology	J:305430
	abnormal male germ cell physiology	J:305430
	abnormal mitochondrial ATP synthesis coupled electron transport	J:305430
	abnormal mitochondrial morphology	J:305430
	abnormal sperm head morphology	J:305430
	abnormal spermatid morphology	J:305430
	abnormal spermatocyte morphology	J:305430
	abnormal spermatogenesis	J:305430
	absent sperm head	J:305430
	normal cellular phenotype	J:305430
	coiled sperm flagellum	J:305430
	decreased male germ cell number	J:305430
	decreased testis weight	J:305430
	increased male germ cell apoptosis	J:305430
	increased mitochondrial DNA content	J:305430
	increased mitochondrial fission	J:305430
	increased testis apoptosis	J:305430
	male infertility	J:305430
	oligozoospermia	J:305430
	seminiferous tubule degeneration	J:305430
	small epididymis	J:305430
	small seminiferous tubules	J:305430
	small testis	J:305430
	teratozoospermia	J:305430
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc/0 Not Specified	abnormal mitochondrial morphology	J:132035
	kinked tail	J:132035
	normal limbs/digits/tail phenotype	J:132035
	short tail	J:132035
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc/Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc Not Specified	abnormal autopod morphology	J:132035
	abnormal gait	J:132035
	abnormal hindlimb morphology	J:132035
	abnormal limb posture	J:132035
	abnormal mitochondrial morphology	J:132035
	abnormal motor neuron morphology	J:132035
	abnormal tail morphology	J:132035
	decreased body weight	J:132035
	decreased skeletal muscle size	J:132035
	muscle weakness	J:132035
	short tail	J:132035