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Transgene Detail
Symbol: Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc
Name: transgene insertion 1, David C Chan
MGI ID: MGI:6198713
Synonyms: Mfn2T105M, Tg1Mfn2T105M
Transgene: Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc  Location: unknown  Genetic Position: Chr11, Syntenic
Alliance: Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc page
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc expresses 1 gene
Mutation detailsThe Mnx1 (homeobox HB9) promoter drives the expression of a C-terminally Myc-tagged mouse mitofusin 2 with the T105M mutation found in families with Charcot-Marie-Tooth disease type 2A followed by an IRES and an EGFP in motor neurons. Western blot analysis with an anti-Myc antibody confirmed expression of the transgene. Sequence analysis of the insertion site indicates that the transgene inserted into a non-coding region on chromosome 11 between genes Rad51c and Ppm1e. (J:132035)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:132035 Detmer SA, et al., Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet. 2008 Feb 1;17(3):367-75
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory