Slc6a3^tm1(cre)Lrsn
Targeted Allele Detail

Summary

• Symbol: Slc6a3^tm1(cre)Lrsn
• Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Nils-Goran Larsson
• MGI ID: MGI:3702746
• Synonyms: DAT-cre
• Gene: Slc6a3 Location: Chr13:73684866-73726791 bp, + strand Genetic Position: Chr13, 40.1 cM
• Alliance: Slc6a3^tm1(cre)Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119515
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Slc6a3^tm1(cre)Lrsn expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a3 (MGI:94862)

• Mutation details: Cre recombinase cDNA and an frt-flanked neo cassette was inserted into exon 2. Crossing with mice expressiong FLP recombinase in the germline removed the neo. These mice express cre recombinase in nigrostriatal dopamine neurons of the midbrain. (J:119515)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a3 (mouse) Summary of all recombinase alleles driven by Slc6a3. Alliance mouse Slc6a3 gene page

Disease models

Expression

In Mice Carrying this Mutation:

52018 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a3 Mutation: 66 strains or lines available

References

• Original: J:119515 Ekstrand MI, et al., Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30
• All: 63 reference(s)