About   Help   FAQ
Slc6a3tm1(cre)Lrsn
Targeted Allele Detail
Summary
Symbol: Slc6a3tm1(cre)Lrsn
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Nils-Goran Larsson
MGI ID: MGI:3702746
Synonyms: DAT-cre
Gene: Slc6a3  Location: Chr13:73684866-73726791 bp, + strand  Genetic Position: Chr13, 40.1 cM
Alliance: Slc6a3tm1(cre)Lrsn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119515
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Slc6a3tm1(cre)Lrsn expression driven by 1 gene
 
Mutation detailsCre recombinase cDNA and an frt-flanked neo cassette was inserted into exon 2. Crossing with mice expressiong FLP recombinase in the germline removed the neo. These mice express cre recombinase in nigrostriatal dopamine neurons of the midbrain. (J:119515)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc6a3 (mouse)
Summary of all recombinase alleles driven by Slc6a3.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:  66 strains or lines available
References
Original:  J:119515 Ekstrand MI, et al., Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30
All:  64 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/02/2024
MGI 6.13
The Jackson Laboratory