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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Men1
multiple endocrine neoplasia 1
MGI:1316736
127 phenotypes from 13 alleles in 21 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Men1em1Jiez/Men1em1Jiez
C57BL/6-Men1em1Jiez 		abnormal sucrose solution preference J:379428
normal behavior/neurological phenotype J:379428
behavioral despair J:379428
decreased miniature excitatory postsynaptic current frequency J:379428
normal growth/size/body region phenotype J:379428
increased miniature inhibitory postsynaptic current frequency J:379428
normal mortality/aging J:379428
normal nervous system phenotype J:379428
Men1tm1.1Ctre/Men1+
either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N) 		increased pancreas tumor incidence J:67128
pancreatic islet hyperplasia J:67128
Men1tm1.1Ctre/Men1+
involves: 129S6/SvEvTac * C57BL/6 		increased adrenal gland tumor incidence J:120835
increased gland tumor incidence J:120835
increased lung adenocarcinoma incidence J:120835
increased pancreas tumor incidence J:120835
increased parathyroid gland tumor incidence J:120835
increased pituitary gland tumor incidence J:120835
increased testis tumor incidence J:120835
increased thyroid tumor incidence J:120835
Men1tm1.1Ctre/Men1+
involves: 129S6/SvEvTac * FVB/N 		increased adrenal gland tumor incidence J:133299
increased lung tumor incidence J:133299
increased pancreatic islet cell adenoma incidence J:133299
increased parathyroid adenoma incidence J:133299
increased pheochromocytoma incidence J:133299
increased pituitary adenohypophysis tumor incidence J:133299
Men1tm1.1Ctre/Men1tm1.1Ctre
either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N) 		embryonic lethality during organogenesis, complete penetrance J:67128
Men1tm1.1Gfk/Men1+
involves: 129T2/SvEms * C57BL/6 		abnormal pancreas morphology J:116086
abnormal pituitary gland morphology J:116086
increased adrenal gland adenoma incidence J:116086
increased glucagonoma incidence J:116086
increased insulinoma incidence J:116086
increased Leydig cell number J:116086
increased Leydig cell tumor incidence J:116086
increased ovary tumor incidence J:116086
increased pancreas adenoma incidence J:116086
increased parathyroid adenoma incidence J:116086
increased pituitary adenoma incidence J:116086
increased prolactinoma incidence J:116086
pancreatic islet hyperplasia J:116086
parathyroid gland hyperplasia J:116086
thyroid gland hyperplasia J:116086
Men1tm1.1Zqw/Men1tm1.1Zqw
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell differentiation J:83882
abnormal neural tube closure J:83882
lethality throughout fetal growth and development, complete penetrance J:83882
Men1tm1.2Ctre/Men1+
Tg(Ins2-cre)25Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		increased insulinoma incidence J:85042
Men1tm1.2Ctre/Men1+
Pax3tm1(cre)Joe/Pax3+
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:127545
Men1tm1.2Ctre/Men1+
Tg(Ins2-cre)1Heed/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		increased insulinoma incidence J:85042
Men1tm1.2Ctre/Men1+
Tg(Ins2-cre)1Dh/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		increased insulinoma incidence J:85042
Men1tm1.2Ctre/Men1tm1.2Ctre
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal basisphenoid bone morphology J:127545
abnormal palatal shelf bone ossification J:127545
abnormal pterygoid process morphology J:127545
absent gastric milk in neonates J:127545
bilateral cleft palate J:127545
cleft secondary palate J:127545
palatal shelves fail to meet at midline J:127545
perinatal lethality, complete penetrance J:127545
normal skeleton phenotype J:127545
Men1tm1.2Ctre/Men1tm1.2Ctre
Pax3tm1(cre)Joe/Pax3+
involves: 129S6/SvEvTac 		abnormal basisphenoid bone morphology J:127545
abnormal palatal mesenchymal cell differentiation J:127545
abnormal palatal mesenchymal cell proliferation J:127545
abnormal palatal shelf bone ossification J:127545
abnormal pterygoid process morphology J:127545
abnormal rib development J:127545
abnormal rib morphology J:127545
abnormal secondary palate development J:127545
abnormal snout morphology J:127545
abnormal sternum morphology J:127545
abnormal sternum ossification J:127545
absent gastric milk in neonates J:127545
bilateral cleft palate J:127545
cleft secondary palate J:127545
cyanosis J:127545
meteorism J:127545
palatal shelf hypoplasia J:127545
palatal shelves fail to meet at midline J:127545
perinatal lethality, complete penetrance J:127545
primary atelectasis J:127545
respiratory distress J:127545
rib bifurcation J:127545
rib fusion J:127545
short snout J:127545
short soft palate J:127545
Men1tm1.2Ctre/Men1tm1.2Ctre
Tg(Ins2-cre)1Dh/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		decreased circulating glucose level J:85042
increased circulating insulin level J:85042
increased insulinoma incidence J:85042
pancreatic islet hyperplasia J:85042
Men1tm1.2Ctre/Men1tm1.2Ctre
Tg(Ins2-cre)1Heed/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		decreased circulating glucose level J:85042
increased circulating insulin level J:85042
increased insulinoma incidence J:85042
pancreatic islet hyperplasia J:85042
Men1tm1.2Ctre/Men1tm1.2Ctre
Tg(Ins2-cre)25Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		decreased circulating glucose level J:85042
increased circulating insulin level J:85042
increased insulinoma incidence J:85042
pancreatic islet hyperplasia J:85042
Men1tm1.2Ctre/Men1tm1.2Ctre
Tg(Myh6-cre)2182Mds/0
involves: 129S6/SvEvTac * FVB/N 		no abnormal phenotype detected J:127545
Men1tm1.2Ctre/Men1tm1.2Ctre
Tg(Pax3-cre)1Joe/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal rib morphology J:127545
bilateral cleft palate J:127545
cleft secondary palate J:127545
perinatal lethality, complete penetrance J:127545
short soft palate J:127545
Men1tm1.2Ctre/Men1tm1.2Ctre
Tg(PTH-cre)4167Slib/0
Not Specified 		abnormal blood homeostasis J:86642
enlarged parathyroid gland J:86642
increased circulating calcium level J:86642
Men1tm1.2Zqw/Men1tm1.2Zqw
Pgrtm2(cre)Lyd/Pgr+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal decidualization J:322043
abnormal DNA methylation J:322043
abnormal embryo development J:322043
abnormal placenta development J:322043
abnormal trophoblast giant cell morphology J:322043
decreased litter size J:322043
decreased uterine NK cell number J:322043
embryonic growth retardation J:322043
impaired embryo implantation J:322043
increased endometrial gland number J:322043
increased miscarriage rate J:322043
reduced female fertility J:322043
Men1tm1.2Zqw/Men1tm1.2Zqw
Tg(Ins2-cre)23Herr/0
involves: 129P2/OlaHsd * C57BL/6J * CBA/J 		hypoglycemia J:85133
increased circulating insulin level J:85133
increased insulinoma incidence J:85133
pancreatic islet hyperplasia J:85133
Men1tm1.2Zqw/Men1tm1.2Zqw
Tg(Runx2-icre)1Jtuc/0
involves: 129P2/OlaHsd * FVB/N 		arrested osteoblast differentiation J:257886
increased fibroma incidence J:257886
Men1tm1.2Zqw/Men1tm1.2Zqw
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129P2/OlaHsd * CD-1 		increased fibroma incidence J:257886
Men1tm1Ctre/Men1+
either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N) 		abnormal pancreas morphology J:67128
abnormal pancreatic acinar cell morphology J:67128
increased adrenal gland tumor incidence J:67128
increased carcinoma incidence J:67128
increased circulating insulin level J:67128
increased lung adenocarcinoma incidence J:67128
increased pancreas tumor incidence J:67128
increased parathyroid adenoma incidence J:67128
increased pheochromocytoma incidence J:67128
increased pituitary adenoma incidence J:67128
increased prolactinoma incidence J:67128
increased stomach tumor incidence J:67128
increased thyroid adenoma incidence J:67128
pancreas cyst J:67128
pancreas inflammation J:67128
pancreas necrosis J:67128
pancreatic islet hyperplasia J:67128
thyroid gland cyst J:67128
Men1tm1Ctre/Men1+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N 		increased circulating insulin level J:146440
Men1tm1Ctre/Men1tm1Ctre
either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N) 		abnormal craniofacial development J:67128
decreased embryo size J:67128
embryonic growth retardation J:67128
embryonic lethality during organogenesis, complete penetrance J:67128
Men1tm1Ctre/Men1tm1Ctre
Tg(Pdx1-cre)89.1Dam/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N 		abnormal blood vessel morphology J:146440
abnormal pancreas physiology J:146440
abnormal pancreatic islet morphology J:146440
decreased circulating glucose level J:146440
enlarged pancreatic islets J:146440
increased circulating insulin level J:146440
increased insulinoma incidence J:146440
pancreatic islet hyperplasia J:146440
premature death J:146440
Men1tm1Gfk/Men1tm1Gfk
Tg(Ins2-cre)25Mgn/0
involves: 129T2/SvEms * C57BL/6 * C57BL/6J * DBA 		increased insulinoma incidence J:89898
increased pancreas tumor incidence J:89898
increased prolactinoma incidence J:89898
pancreatic islet hyperplasia J:89898
Men1tm1Mmey/Men1+
involves: 129S6/SvEvTac * FVB/N 		hypoglycemia J:102494
increased pancreatic beta cell number J:102494
Men1tm1Mmey/Men1tm1Mmey
involves: 129S6/SvEvTac * FVB/N 		embryonic lethality during organogenesis, complete penetrance J:88588
Men1tm1Rvt/Men1+
involves: 129 * C57BL/6 		decreased circulating phosphate level J:191261
decreased tumor-free survival time J:191261
normal homeostasis/metabolism phenotype J:191261
increased adrenal cortical tumor incidence J:191261
increased circulating calcium level J:191261
increased circulating corticosterone level J:191261
increased Leydig cell number J:191261
increased ovary tumor incidence J:191261
increased pancreatic islet cell adenoma incidence J:191261
increased parathyroid adenoma incidence J:191261
increased parathyroid gland tumor incidence J:191261
increased pituitary adenohypophysis tumor incidence J:191261
increased pituitary gland tumor incidence J:191261
increased testis tumor incidence J:191261
increased thyroid tumor incidence J:191261
increased tumor incidence J:191261
pancreatic islet hyperplasia J:191261
parathyroid gland hyperplasia J:191261
Men1tm1Rvt/Men1tm1Rvt
involves: 129 * C57BL/6 		embryonic lethality, complete penetrance J:191261
Men1tm1Zqw/Men1+
involves: 129/Sv * 129P2/OlaHsd 		enlarged adrenal glands J:85302
enlarged ovary J:85302
enlarged pituitary gland J:85302
enlarged testis J:85302
increased adrenal cortical tumor incidence J:85302
increased adrenal gland adenoma incidence J:85302
increased adrenal gland tumor incidence J:85302
increased adrenocortical adenoma incidence J:85302
increased gastrointestinal tumor incidence J:85302
increased gland tumor incidence J:85302
increased glucagonoma incidence J:85302
increased gonad tumor incidence J:85302
increased insulinoma incidence J:85302
increased intestinal adenoma incidence J:85302
increased Leydig cell tumor incidence J:85302
increased mammary gland tumor incidence J:85302
increased ovary tumor incidence J:85302
increased pancreas tumor incidence J:85302
increased pancreatic islet cell adenoma incidence J:85302
increased pancreatic islet cell carcinoma incidence J:85302
increased parathyroid adenoma incidence J:85302
increased pituitary adenohypophysis tumor incidence J:85302
increased prolactinoma incidence J:85302
increased stomach tumor incidence J:85302
increased testis tumor incidence J:85302
increased thyroid carcinoma incidence J:85302
increased thyroid tumor incidence J:85302
thyroid gland hyperplasia J:85302
Men1tm1Zqw/Men1tm1Zqw
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) 		abnormal embryonic tissue morphology J:83882
abnormal neural tube closure J:83882
decreased embryo size J:83882
delayed hepatic development J:83882
exencephaly J:83882
hemorrhage J:83882
lethality throughout fetal growth and development, complete penetrance J:83882
thin interventricular septum J:83882
thin ventricular wall J:83882
trabecula carnea hypoplasia J:83882
Men1tm2.1Gfk/Men1+
involves: 129T2/SvEms * C57BL/6 		abnormal pituitary gland morphology J:116086
increased insulinoma incidence J:116086
increased Leydig cell tumor incidence J:116086
increased ovary tumor incidence J:116086
increased pancreas adenoma incidence J:116086
increased parathyroid adenoma incidence J:116086
increased pituitary adenoma incidence J:116086
thyroid gland hyperplasia J:116086
Men1tm2.1Mmey/Men1tm2.1Mmey
Tg(Ins2-cre)23Herr/0
involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N 		abnormal pancreas physiology J:175625
abnormal pancreatic islet morphology J:175625
increased insulinoma incidence J:175625
pancreatic islet hyperplasia J:175625
premature death J:175625
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06/09/2026
MGI 6.24 		The Jackson Laboratory