62 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Creb1tm3Gsc/Creb1+ Lrp5tm1Kry/Lrp5+ Tg(Col1a1-cre)1Kry/0 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB	decreased bone mass	J:146078
	decreased bone ossification	J:146078
Hivep3tm1Glm/Hivep3tm1Glm Lrp5tm3.2Mawa/Lrp5tm3.2Mawa involves: 129S1/Sv * C57BL/6	abnormal bone trabecula morphology	J:201597
	increased bone mass	J:201597
	increased bone trabecula number	J:201597
	increased bone volume	J:201597
	increased compact bone thickness	J:201597
	increased trabecular bone thickness	J:201597
Htr1btm1Rhn/Htr1b+ Lrp5tm1Kry/Lrp5tm1Kry involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	normal skeleton phenotype	J:146078
Lrp5Gt(OST164883)Lex/Lrp5+ Tspan12tm1Wye/Tspan12+ either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)	abnormal retina vasculature morphology	J:154863
Lrp5tm1.1Vari/Lrp5tm1.1Vari Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:178499
	abnormal bone structure	J:178499
	abnormal cartilage morphology	J:178499
	abnormal cranium morphology	J:178499
	abnormal epiphyseal plate morphology	J:178499
	abnormal limb morphology	J:178499
	abnormal skeleton morphology	J:178499
	abnormal trabecular bone morphology	J:178499
	decreased body size	J:178499
	ectopic cartilage	J:178499
	neonatal lethality, complete penetrance	J:178499
	split sternum	J:178499
Lrp5tm1.2Vari/Lrp5tm1.2Vari Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:178499
	abnormal bone structure	J:178499
	abnormal cartilage morphology	J:178499
	abnormal cranium morphology	J:178499
	abnormal epiphyseal plate morphology	J:178499
	abnormal joint morphology	J:178499
	abnormal limb morphology	J:178499
	abnormal osteoblast differentiation	J:178499
	abnormal skeleton morphology	J:178499
	abnormal trabecular bone morphology	J:178499
	decreased body size	J:178499
	decreased width of hypertrophic chondrocyte zone	J:178499
	ectopic cartilage	J:178499
	failure of bone ossification	J:178499
	neonatal lethality, complete penetrance	J:178499
	split sternum	J:178499
Lrp5tm1Grw/Lrp5tm1Grw Sosttm1Paz/Sosttm1Paz involves: 129S1/Sv * 129X1/SvJ * Black Swiss	increased bone mass	J:213541
	increased bone mineral content	J:213541
	increased bone mineral density	J:213541
	increased bone stiffness	J:213541
	increased bone strength	J:213541
	increased bone trabecula number	J:213541
	increased bone volume	J:213541
	increased compact bone mass	J:213541
	increased trabecular bone mass	J:213541
Lrp5tm1Jfh/Lrp5+ Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129S5/SvEvBrd * C57BL/6	abnormal bone ossification	J:91055
	forelimb oligodactyly	J:91055
Lrp5tm1Jfh/Lrp5+ Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg involves: 129S5/SvEvBrd * C57BL/6	abnormal amnion morphology	J:91055
	abnormal developmental patterning	J:91055
	abnormal extraembryonic tissue morphology	J:91055
	abnormal primitive streak formation	J:91055
	absent somites	J:91055
	increased forebrain size	J:91055
	lethality throughout fetal growth and development, complete penetrance	J:91055
Lrp5tm1Jfh/Lrp5tm1Jfh Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129S5/SvEvBrd * C57BL/6	absent carpal bone	J:91055
	absent fibula	J:91055
	absent metacarpal bones	J:91055
	decreased body size	J:91055
	decreased fetal size	J:91055
	oligodactyly	J:91055
	postnatal lethality, incomplete penetrance	J:91055
Lrp5tm1Jfh/Lrp5tm1Jfh Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg involves: 129S5/SvEvBrd * C57BL/6	abnormal developmental patterning	J:91055
	abnormal germ layer development	J:91055
	abnormal mesoderm development	J:91055
	absent allantois	J:91055
	absent amnion	J:91055
	absent endoderm	J:91055
	lethality throughout fetal growth and development, complete penetrance	J:91055
Lrp5tm1Kry/Lrp5tm1Kry Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat Edil3Tg(Sox2-cre)1Amc/? involves: 129 * C57BL/6 * CBA	abnormal angiogenesis	J:154020
	abnormal descending aorta morphology	J:154020
	embryonic growth retardation	J:154020
	embryonic lethality, incomplete penetrance	J:154020
Lrp5tm1Kry/Lrp5tm1Kry Sostdc1tm1Snd/Sostdc1tm1Snd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal skeleton phenotype	J:216098
Lrp5tm1Kry/Lrp5tm1Kry Sostdc1tm2Snd/Sostdc1tm2Snd involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	normal skeleton phenotype	J:216098
Lrp5tm1Kry/Lrp5tm1Kry Tph1tm1Kry/Tph1+ Tg(Vil1-cre)20Syr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	normal skeleton phenotype	J:146078
Lrp5tm1Lex/Lrp5+ Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	abnormal forelimb morphology	J:111359
	abnormal limb morphology	J:111359
	decreased bone mass	J:111359
	decreased bone mineral density	J:111359
	forelimb oligodactyly	J:111359
	synostosis	J:111359
Lrp5tm1Lex/Lrp5tm1Lex Lrp6Gt(Ex187)Byg/Lrp6+ involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	abnormal carpal bone morphology	J:111359
	abnormal cranium morphology	J:111359
	abnormal forelimb morphology	J:111359
	abnormal hindlimb morphology	J:111359
	abnormal limb morphology	J:111359
	abnormal tarsal bone morphology	J:111359
	decreased bone mass	J:111359
	decreased bone mineral density	J:111359
	forelimb oligodactyly	J:111359
	monodactyly	J:111359
	synostosis	J:111359
Lrp5tm1Lex/Lrp5tm1Lex Lrp6Gt(Ex187)Byg/Lrp6Gt(Ex187)Byg involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	decreased bone mineral density	J:111359