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Targeted Allele Detail
Symbol: Sosttm1Paz
Name: sclerostin; targeted mutation 1, Chris Paszty
MGI ID: MGI:3850014
Synonyms: Sost-
Gene: Sost  Location: Chr11:101853284-101857841 bp, - strand  Genetic Position: Chr11, 65.48 cM, cytoband D
Alliance: Sosttm1Paz page
Germline Transmission:  Earliest citation of germline transmission: J:150166
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe open reading frame was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on femur extracts. (J:150166)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 108 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sost Mutation:  29 strains or lines available
Original:  J:150166 Li X, et al., Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res. 2008 Jun;23(6):860-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory