Tph1^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Tph1^tm1Kry
• Name: tryptophan hydroxylase 1; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:3837399
• Gene: Tph1 Location: Chr7:46294065-46321961 bp, - strand Genetic Position: Chr7, 30.43 cM
• Alliance: Tph1^tm1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146078
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette in inverse orientation was inserted into intron 1 and a loxP site was inserted into intron 3 via homologous recombination. The neo cassette was later removed leaving exons 2 and 3 floxed. (J:146078)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph1 Mutation: 39 strains or lines available

References

• Original: J:146078 Yadav VK, et al., Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell. 2008 Nov 28;135(5):825-37
• All: 20 reference(s)