All Phenotypes Tph1<tm1Kry> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tph1^tm1Kry
targeted mutation 1, Gerard Karsenty
MGI:3837399

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lrp5^tm1Kry/Lrp5^tm1Kry Tph1^tm1Kry/Tph1⁺ Tg(Vil1-cre)20Syr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:3837415
cn2	Htr1b^tm1Rhn/Htr1b⁺ Tph1^tm1Kry/Tph1⁺ Tg(Vil1-cre)20Syr/0	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:3837413
cn3	Tph1^tm1Kry/Tph1^tm1Kry Tg(Vil1-cre)20Syr/0	involves: C57BL/6 * DBA/2	MGI:3837407
cn4	Tph1^tm1Kry/Tph1^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: FVB	MGI:3837408

Allelic Composition	Lrp5^tm1Kry/Lrp5^tm1Kry Tph1^tm1Kry/Tph1⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1Kry mutation (0 available); any Lrp5 mutation (81 available)
Tg(Vil1-cre)20Syr mutation (3 available)
Tph1^tm1Kry mutation (0 available); any Tph1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:146078 )

N	• loss of expression of 1 copy of Tph1 in the gut rescues the bone phenotype seen in Lrp5 null mice

Allelic Composition	Htr1b^tm1Rhn/Htr1b⁺ Tph1^tm1Kry/Tph1⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (27 available)
Tg(Vil1-cre)20Syr mutation (3 available)
Tph1^tm1Kry mutation (0 available); any Tph1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mass ( J:146078 )

• phenotype is the same as in mice homozygous null for Htr1b and mice conditional null for Tph1 in the gut

Allelic Composition	Tph1^tm1Kry/Tph1^tm1Kry Tg(Vil1-cre)20Syr/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)20Syr mutation (3 available)
Tph1^tm1Kry mutation (0 available); any Tph1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased osteoblast proliferation ( J:146078 )

• increased osteoblast proliferation

homeostasis/metabolism

decreased serotonin level ( J:146078 )

• decreased circulating serotonin levels

skeleton

increased osteoblast proliferation ( J:146078 )

• increased osteoblast proliferation

increased osteoblast cell number ( J:146078 )

increased bone mass ( J:146078 )

• severe

• ovariectomy does not result in decreased bone mass unlike in controls

increased bone ossification ( J:146078 )

• increased bone formation

Allelic Composition	Tph1^tm1Kry/Tph1^tm1Kry Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col1a1-cre)1Kry mutation (2 available)
Tph1^tm1Kry mutation (0 available); any Tph1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:146078 )

N	• unlike mice with conditional deletion in the gut, mice with conditional expression in osteoblasts have normal circulating serotonin levels

skeleton

skeleton phenotype ( J:146078 )

N	• unlike mice with conditional deletion in the gut, mice with conditional expression in osteoblasts have no significant increase in bone mass or osteoblast proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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