Htr1b^tm1Rhn
Targeted Allele Detail

Summary

• Symbol: Htr1b^tm1Rhn
• Name: 5-hydroxytryptamine (serotonin) receptor 1B; targeted mutation 1, Rene Hen
• MGI ID: MGI:2653030
• Synonyms: 5-HT1B-, 5HT1B^-
• Gene: Htr1b Location: Chr9:81510344-81515881 bp, - strand Genetic Position: Chr9, 44.61 cM
• Alliance: Htr1b^tm1Rhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20209
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into the coding region via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by audoradiography of the brain. (J:20209, J:96318)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Htr1b Mutation: 27 strains or lines available

References

• Original: J:20209 Saudou F, et al., Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science. 1994 Sep 23;265(5180):1875-8
• All: 61 reference(s)