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Htr1b Gene Detail
Summary
  • Symbol
    Htr1b
  • Name
    5-hydroxytryptamine (serotonin) receptor 1B
  • Synonyms
    5-HT1B receptor, 5-HT1B receptor, 5HT1B receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96274
    NCBI Gene: 15551
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:81510344-81515881 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 44.61 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96274
 protein coding gene Chr9:81510344-81515885 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035081
 protein coding gene Chr9:82233990-82239531 (-)
A/J MGP_AJ_G0035062
 protein coding gene Chr9:79365409-79371111 (-)
AKR/J MGP_AKRJ_G0034990
 protein coding gene Chr9:81208575-81214116 (-)
BALB/cJ MGP_BALBcJ_G0035050
 protein coding gene Chr9:79013452-79018987 (-)
C3H/HeJ MGP_C3HHeJ_G0034762
 protein coding gene Chr9:81771222-81781049 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035573
 protein coding gene Chr9:84481439-84486954 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032481
 protein coding gene Chr9:78421643-78427152 (-)
CAST/EiJ MGP_CASTEiJ_G0034080
 protein coding gene Chr9:82156935-82162464 (-)
CBA/J MGP_CBAJ_G0034735
 protein coding gene Chr9:87445498-87455909 (-)
DBA/2J MGP_DBA2J_G0034893
 protein coding gene Chr9:78993650-78999177 (-)
FVB/NJ MGP_FVBNJ_G0034836
 protein coding gene Chr9:78146456-78151991 (-)
LP/J MGP_LPJ_G0034974
 protein coding gene Chr9:82431769-82437310 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034878
 protein coding gene Chr9:88749371-88754890 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035594
 protein coding gene Chr9:81455109-81460638 (-)
PWK/PhJ MGP_PWKPhJ_G0033784
 protein coding gene Chr9:79165834-79171419 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033620
 protein coding gene Chr9:81583557-81589090 (-)
WSB/EiJ MGP_WSBEiJ_G0034197
 protein coding gene Chr9:81389191-81394712 (-)



Homology
more
  • Human Ortholog
    HTR1B, 5-hydroxytryptamine receptor 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR1B, 5-hydroxytryptamine receptor 1B
  • Synonyms
    5-HT1B, 5-HT-1B, 5-HT1DB, 5-HT-1D-beta, HTR1D2, HTR1DB, S12
  • Links
    NCBI Gene ID: 3351
    neXtProt AC: NX_P28222
    UniProt: P28222

  • Chr Location
    6q14.1; chr6:77460924-77463491 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HTR1B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit an increase in body weight, aggression, drinking behavior, and osteoblast proliferation and bone mass, and show altered spatial learning and operant conditional behavior as well as reduced anxiety-related response and startle reflex, and small testes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    948
  • Tissues
    148
  • cDNA Data
    5
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049511 Ensembl Gene Model | MGI Sequence Detail 5538 C57BL/6J ±  kb
    transcript ENSMUST00000183482 Ensembl | MGI Sequence Detail 4724 Not Applicable  
    polypeptide ENSMUSP00000139389 Ensembl | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 5
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11000
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 13
      Gene Ontology 13
      Phenotypes 77
    • Earliest
      J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
    • Latest
      J:333866 Desrochers SS, et al., Serotonin 1B receptor effects on response inhibition are independent of inhibitory learning. Neurobiol Learn Mem. 2022 Jan;187:107574
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory