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Creb1tm3Gsc
Targeted Allele Detail
Summary
Symbol: Creb1tm3Gsc
Name: cAMP responsive element binding protein 1; targeted mutation 3, Gunther Schutz
MGI ID: MGI:2181395
Synonyms: Creb1loxP, CREBfl, Creblox
Gene: Creb1  Location: Chr1:64571963-64643707 bp, + strand  Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
Alliance: Creb1tm3Gsc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76211
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted 5' to exon 10 and a loxP flanked neomycin and thymidine kinase cassette was inserted 3' to exon 10. Transient transfection of Cre recombinase in ES cells resulted in the deletion of the neomycin and thymidine kinase cassette, leaving single loxP sites flanking exon 10 in the final allele. (J:76211)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Creb1 Mutation:  59 strains or lines available
References
Original:  J:76211 Mantamadiotis T, et al., Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002 May;31(1):47-54
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory